DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkcdelta and akt2l

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	XP_021334818.1	Gene:	akt2l / 403146	ZFINID:	ZDB-GENE-040121-5	Length:	625	Species:	Danio rerio

Alignment Length:	360	Identity:	151/360 - (41%)
Similarity:	215/360 - (59%)	Gaps:	24/360 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly  1527 SSPKKMLETSYTYSQFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYY 1591
            |||...|| .......:.|.|.|             ::||.:|.:||||:||||:|...:.:..|
Zfish   124 SSPSDALE-DMEMCLSKSSSRVT-------------MNDFDYLKLLGKGTFGKVILVREKASGMY 174

  Fly  1592 YAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHI 1656
            ||:|.|:|:|::..|:|..|:.|.:||. .|:||:|..|...|||...|.|||||.|||:|.||:
Zfish   175 YAMKILRKEVIIAKDEVAHTVTESRVLQ-NTRHPFLTTLKYAFQTHDRLCFVMEYANGGELFFHL 238

  Fly  1657 QESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKT 1721
            .....|||:|||||||||:|.|.:.|.:.::||.|||:|::||.:||::|.|||:||..|..:.|
Zfish   239 SRERVFSEDRARFYGAEIVSALDYPHSQNVVYRHLKLENLMLDNDGHIKITDFGLCKEGITDEAT 303

  Fly  1722 ADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPV 1786
            ..:|||||:|:|||:::...|.:.||||..||::|||:.|:.||...|.:.||..|..|...||.
Zfish   304 MRTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYSQDHERLFEQIVMEEIRFPR 368

  Fly  1787 YISAEATGILKGLLEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDT 1851
            .:|..|..:|.|||.|:..:|:|.....|.|:..|.||..:.|..:.::::.|||||||....||
Zfish   369 SLSTHARALLTGLLRKEPKQRLGGGPDDARDVMMHKFFSGVQWDDVLQKKLLPPFKPQVTSETDT 433

  Fly  1852 QYFDRVFTRERVRLTPIDK---------EILASMD 1877
            :|||..||.:.:.:||.||         |:|...|
Zfish   434 RYFDDEFTAQSITVTPPDKLSCQDVEEPEVLEDND 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	118/257 (46%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	140/317 (44%)
akt2l	XP_021334818.1	PH_PKB	4..111	CDD:269947
		PKc_like	153..462	CDD:328722	137/309 (44%)
		PKc_like	<423..551	CDD:328722	19/46 (41%)
		S_TK_X	553..621	CDD:214529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910