Protein Alignment Pkcdelta and Pdk1

DIOPT Version :10

• Sequence 1: NP_572797.3
• Gene: Pkcdelta / 32191
• FlyBaseID: FBgn0287828
• Length: 1894
• Species: Drosophila melanogaster
• Sequence 2: NP_728471.2
• Gene: Pdk1 / 38017
• FlyBaseID: FBgn0020386
• Length: 836
• Species: Drosophila melanogaster
• Alignment Length: 546
• Identity: 135/546 - (24%)
• Similarity: 223/546 - (40%)
• Gaps: 122/546 - (22%)

  Fly  1442 EECSSTSSSASSE----DLDAVAMVTKAGS--------SNATTVLDSSNSSGSNAGTL------- 1487
            |:.|:|.|...|.    :|..:|:|.:|.|        .....|..:.|::.|..|:.
  Fly    88 EKASATVSLGESNFRDINLKDLAVVVEAASRLHHQQNVCGCGAVSSTENNNNSRYGSSKYLTNGH 152

  Fly  1488 SVPSAGSGSGGGASTSSSPSIIRMSTCS-----ND----------------SGFEGGTAPSSPKK 1531
            :.|.|.:.:...:|.:::|....:..||     ||                .|::.......|::
  Fly   153 TSPLAAAVASNSSSVATTPHCRMLHNCSLQQYQNDIRQQTEILDMLRQQHQQGYQSQQQQQQPQQ 217

  Fly  1532 MLETSYTYSQFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKC 1596
            ..|......|.|:..:...||   ||   .|.:||.|...:|:||:..|.||....:...||||.
  Fly   218 QQEQQQQQEQSQQQQQLQNPA---PR---RSPNDFIFGRYIGEGSYSIVYLAVDIHSRREYAIKV 276

  Fly  1597 LKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGR 1661
            .:|.::|.:...|....||:|:...|..|...:|.||||.:..|:|||.|...||::.:|...|.
  Fly   277 CEKRLILRERKQDYIKREREVMHQMTNVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRVGS 341

  Fly  1662 FSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKL------------ 1714
            |.....|.|.||::...:.:|::.:::||||.:|:|||.:.|..|||||..|:
  Fly   342 FDVACTRHYAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALATEH 406

  Fly  1715 -----------------------QIYLDKTAD------------------------------SFC 1726
                                   :.:.|:.::                              ||.
  Fly   407 CSEQRRSNSDEDDEDSDRLENEDEDFYDRDSEELDDGDDEQQQEEMDSPRHRQRRYNRHRKASFV 471

  Fly  1727 GTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAE 1791
            ||..|::||:::........|.|:.|.::|:|:.|..||.|.::..:|..|.:....||.....:
  Fly   472 GTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGLPPFRGSNDYVIFKEILDCAVDFPQGFDKD 536

  Fly  1792 ATGILKGLLEKDYTKRIGSQ--YSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYF 1854
            |..:::.||..|...|:|:|  :.....|..|.||..|||..| ::|..||..|.:......:.|
  Fly   537 AEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQTL-RQQTPPPIYPYLPGVSQDEDF 600

  Fly  1855 DRVFTRERVRLTPIDKEILASMDQKQ 1880
            ...:|      .|.|.|  ..:|::|
  Fly   601 RSSYT------VPGDLE--PGLDERQ 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	Herpes_BLLF1	<802..1131	CDD:282904
		STKc_nPKC_theta_like	1570..1889	CDD:270744	100/378 (26%)
Pdk1	NP_728471.2	STKc_PDK1	244..571	CDD:270733	86/326 (26%)
		PH_PDK1	658..764	CDD:241293