DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and pkn3

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	XP_003198687.2	Gene:	pkn3 / 323182	ZFINID:	ZDB-GENE-030131-1902	Length:	940	Species:	Danio rerio

Alignment Length:	954	Identity:	259/954 - (27%)
Similarity:	426/954 - (44%)	Gaps:	187/954 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1024 NTPTTATGKSKLNETAGPKINSGQPAKSPEQQQATAAAVETKINKTTDKEQQQQQQQ---QQQQQ 1085
            |....||.|..:.:.|    .|..|....|......:.|.|...:.|.:.:.:|..:   |....
Zfish    87 NARAMATQKENVMDDA----TSPDPCHWEEVTSPLGSHVRTLKKQLTMELKVKQGAENIIQTYTN 147

  Fly  1086 AQQQQQQLIDTAATLVPQTETK--------TKLTEAAEPTGKSKVQSPNTTKPKSAGKTNVGKKK 1142
            :..:.::::.||..::..:.||        .|:|:|.|...::..|....::..|..:..|.:.:
Zfish   148 SSVKDRKMLSTAQQMLQDSRTKIELLRMQIVKVTQAREGERETTQQEGRPSETISPLELRVEELR 212

  Fly  1143 AATPAAAAAAAAAAAPAAATATEAV---TALSESNVTPINADQFITLAPTKAAKTSPNKQQALQL 1204
            ......||.|..|...........|   .||:|:......:.|.:.|.....      :||..:|
Zfish   213 HHLRIEAAVAEGAKNVVKQLGVRKVQDRRALAEAQARLQESSQKLDLLRLSL------EQQLGEL 271

  Fly  1205 QQQHEEQQRQQQQQATNASSPAATGDATTTPTTITIGVAAVNVAAVAVVASAAAAAATDAAADAT 1269
            .|.| .::...:::.|..|||.             ||:....:.     :|::|:::....|..|
Zfish   272 PQDH-PKRAAIKEELTVGSSPG-------------IGLQRERLR-----SSSSASSSLFKPASLT 317

  Fly  1270 TSLSSNNSCGEGVGNNLSKFATVSNLAQCLRDVDAELDDYIPSSAENSQEDDDD----------D 1324
            ..|.......:.:..::.....|||:                |||..|..|...          .
Zfish   318 GRLEVRLMGCQDLLESVPGRCRVSNM----------------SSAPGSPSDSKSLRMRTGLSTRS 366

  Fly  1325 DDGSGSSSDDYSSVDGCANLSASMK-----------KKLRKEKKKQKAKAAAAAEAKRFDPHKKI 1378
            .:|..:.:|:.||     .:||.:|           :.|.|:...|    :.:.|.:|   .:::
Zfish   367 TNGKTTKTDELSS-----EISAVLKVDNKIVGRTHWRPLSKDAWNQ----SFSIELER---SREL 419

  Fly  1379 KI-----DTTNKCYVK----EE-------------APRYPLVATPR---------PLWKREKIVY 1412
            :|     |..:.|.||    |:             .|:..|....|         |..:|:|.::
Zfish   420 EIAVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFTEVRFINPVIERHPKLQRQKRIF 484

  Fly  1413 SDENTDD-----ESGSEEGSGGSLDEDSDDESGGEECSSTSSSAS-----SEDLDAVAMVTKAGS 1467
            ..|...:     :......:.|.|     ..|....|:||.::.|     ||.|...::.|...:
Zfish   485 PKEKGKNFLRAAQMNMNFATWGRL-----MMSVLPPCNSTITALSPPLPGSEPLSPPSVSTPPST 544

  Fly  1468 SNATTV-LDSSNSSGSNAGTLSV---PSAG---SGSGGGASTSSSPSIIRMSTCSNDSGFEGGTA 1525
            .::..| |:.|....:....|.:   |||.   ||:....:::....:::....|.
Zfish   545 GDSAVVKLNFSEERPTKPPRLHLAQNPSADESLSGTPARVNSTEDRRVLQARPASQ--------- 600

  Fly  1526 PSSPKKMLETSYTYSQFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTY 1590
            |:..:|                           :...::||:.::|||:|.||||||||.:.|..
Zfish   601 PTPQRK---------------------------EGMQMEDFNCISVLGRGHFGKVLLAEFKRTGK 638

  Fly  1591 YYAIKCLKKDVVLEDDDVDSTLIERKVLAL--GTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLM 1653
            .||||.|||..|:..|:|||.:.|:::...  .::||:|.:|:..|||..|:.|||||..|||||
Zfish   639 LYAIKALKKGDVVTRDEVDSLMCEKRIFETINASRHPFLVNLYGCFQTPDHVCFVMEYSPGGDLM 703

  Fly  1654 FHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQI-Y 1717
            .|| .:..|||.:||||.|.::.||:|||:..|:||||||||:|:|.:|.|||||||:||..: |
Zfish   704 THI-HNNIFSERQARFYSACVLLGLEFLHQNRIVYRDLKLDNLLMDSDGFVRIADFGLCKEGMGY 767

  Fly  1718 LDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIP 1782
            .|:|: :|||||:::|||::....|.:.||||..|||:||||:|:|||.|.||:|:|.||.|:..
Zfish   768 GDRTS-TFCGTPEFLAPEVLTDSNYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEV 831

  Fly  1783 WFPVYISAEATGILKGLLEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKH 1847
            .:|.::|.|:..:::.||:|:..||:|:....|.::..|.||:.|||..|..::::|||.|.:|.
Zfish   832 RYPRFMSPESVSVIQKLLQKNSEKRLGAGEQDANEVKKHRFFQGIDWEALLAKRVKPPFLPSIKT 896

  Fly  1848 PLDTQYFDRVFTRERVRLTPIDKEILASMDQKQFHG-FTYTNPH 1890
            ..|...||..|||.:..|||.......|.:|::|.. |.::..|
Zfish   897 AADVSNFDEEFTRLKPVLTPPQTPFFLSAEQQEFFADFDFSALH 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	127/260 (49%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	150/322 (47%)
pkn3	XP_003198687.2	HR1_PKN_1	25..90	CDD:212012	1/2 (50%)
		HR1	111..183	CDD:320753	12/71 (17%)
		HR1_PKN3_3	199..271	CDD:212027	14/77 (18%)
		C2_PKN-like	379..462	CDD:176069	17/94 (18%)
		STKc_PKN	614..938	CDD:270741	151/325 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583329
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.960