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Protein Alignment Pkcdelta and PKN3

DIOPT Version :10

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0287828	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	XP_006717143.1	Gene:	PKN3 / 29941	HGNCID:	17999	Length:	896	Species:	Homo sapiens

Alignment Length:	887	Identity:	244/887 - (27%)
Similarity:	358/887 - (40%)	Gaps:	215/887 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1045 SGQPAKSPE--------QQQATAAAVETKIN--------KTTDKEQQQQQQQQQQQQAQQQQ--- 1090
            ||.|...||        :....||..|...|        :|.|::...:.|.|.|:.:|:..
Human   176 SGSPEPGPELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLR 240

  Fly  1091 ---QQLIDTAATLVPQTETKTKLTEAAEPTGKSKVQSPNTTKPKSAGKTNVGKKKAATPAAAAAA 1152
               :||::   .|.|....::::|.                           :.:||.|.....:
Human   241 LALEQLLE---QLPPAHPLRSRVTR---------------------------ELRAAVPGYPQPS 275

  Fly  1153 AAAAAPAAATATEAVTALSESNVTPINADQFITLAPTK---AAKTSPNKQQALQLQQQHEEQQRQ 1214
            .....|.|.|.|..|..|        ..:|.:|..|.:   ||..|...:..|:.:.:|   ||.
Human   276 GTPVKPTALTGTLQVRLL--------GCEQLLTAVPGRSPAAALASSPSEGWLRTKAKH---QRG 329

  Fly  1215 QQQQATNASSPAATGDATTTPTTITIGVAAVNVAAVAVVASAAAAAATDAAADATTSLSSNNSCG 1279
            :.:.|:.                    |.||......||.........:.:.|.|..:....:..
Human   330 RGELASE--------------------VLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARE 374

  Fly  1280 EGVGNNLSKFATVSNLAQCLRDVDAELDDYIPSSAENSQEDDDDDDDGSGSSSDDYSSVDGCANL 1344
            ..:|.:...:..:..:| .||     |:|::.::                           |..|
Human   375 LEIGVHWRDWRQLCGVA-FLR-----LEDFLDNA---------------------------CHQL 406

  Fly  1345 SASMKKKLRKEKKKQKAKAAAAAEAKRFDPHKKIKIDTTNKCYVKEEAPRYPLVATPRPLWKREK 1409
            |.|:           ..:....|:....||             |.|..||         |.::|:
Human   407 SLSL-----------VPQGLLFAQVTFCDP-------------VIERRPR---------LQRQER 438

  Fly  1410 IVYSDENTDDESGSEEGSGGSLDEDSDDESGGE-------ECSSTSSSASSEDLDAVAMVTKAGS 1467
            |.......|....|:...|.:        :.|.       .|||.|:.:..:           |.
Human   439 IFSKRRGQDFLRASQMNLGMA--------AWGRLVMNLLPPCSSPSTISPPK-----------GC 484

  Fly  1468 SNATTVLDSSNSSGSNAGTLSVPSAGSGSGGGASTSSSPSIIRMSTCSNDSGFEGGTAPSSPKKM 1532
            ....|.|..                       ||..::||  .........|.|....|..|:..
Human   485 PRTPTTLRE-----------------------ASDPATPS--NFLPKKTPLGEEMTPPPKPPRLY 524

  Fly  1533 LETSYTYSQFQKSGR-FTAPAT-------VIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTT 1589
            |....|..:..::.| ...|.|       ..|..|...:.||..|||||:|.||||||.:.:.|.
Human   525 LPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTG 589

  Fly  1590 YYYAIKCLKKDVVLEDDDVDSTLIERKVL-ALG-TKHPYLCHLFCTFQTESHLFFVMEYLNGGDL 1652
            .|||||.|||..||..|:::|...|:::| |:| |.||:|..|...|||.||..||.|::.||||
Human   590 KYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDL 654

  Fly  1653 MFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIY 1717
            |..|.|. .|.|.:||||.|.::.||:|||:|.||||||||||:|||.:|.::|||||:||..|.
Human   655 MMQIHED-VFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIG 718

  Fly  1718 LDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIP 1782
            ......:|||||:::|||::..|.|.:.||||..||||||||:|:.||.|..|:|:|..|.|...
Human   719 FGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDA 783

  Fly  1783 WFPVYISAEATGILKGLLEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKH 1847
            .:|.::|.:....::.||:|...||:|:....|.:|....|||..:|..|..|.|:|||.|.:..
Human   784 PYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCG 848

  Fly  1848 PLDTQYFDRVFTRERVRLT-PIDKEILASMDQKQFHGFTYTN 1888
            |.|.:||:..||.....|| |....:|.:..|..|..|.:.:
Human   849 PADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVS 890

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.