DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkcdelta and Pkn3

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	XP_006233834.1	Gene:	Pkn3 / 296619	RGDID:	1305921	Length:	883	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	171/417 - (41%)
Similarity:	233/417 - (55%)	Gaps:	13/417 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly  1482 SNAGTLSVPSAGSGSGGGASTSSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSYTYSQFQKSG 1546
            |:..|:| |..|..|.....||||.|...........|.:....|..|:..|:.....:...|..
  Rat   464 SSPSTVS-PPKGCPSAAACETSSSASPSNFRPVKTLPGEDMKPPPKPPRLYLQEPAPGTPCTKRP 527

  Fly  1547 RFTAPATVIPRFKNYS------VDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLED 1605
            .......|.|.....|      :.||..|||||:|.||||||.:.:.|..|||||.|||..||..
  Rat   528 HMDPRTGVAPPLAALSTRNPPQLQDFRCLAVLGRGHFGKVLLVQYKGTGKYYAIKALKKQEVLGR 592

  Fly  1606 DDVDSTLIERKVL-ALG-TKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERAR 1668
            |::||...|:::| .:| |.||:|..|....||.||..||.|:|.|||||..|.|. .|.|.:|.
  Rat   593 DEIDSLYCEKRILETVGRTGHPFLLSLLACIQTSSHACFVTEFLPGGDLMMQIHED-VFPEPQAC 656

  Fly  1669 FYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMA 1733
            ||.|.::.||:|||:|.||||||||||:|||.:|.::|||||:||..|.......:|||||:::|
  Rat   657 FYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLA 721

  Fly  1734 PEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICN-EIPWFPVYISAEATGILK 1797
            ||::..|.|.:.||||..||||||||:|:.||.|..|||:|..|.| ::| .|.::||:...:::
  Rat   722 PEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEDEVFECIVNADVP-CPHFLSAQGLELIQ 785

  Fly  1798 GLLEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRER 1862
            .||:|...||:|:....|.:|....|||..:|..|..|.::|||.|.:..|.|.:||:..||...
  Rat   786 KLLQKSPEKRLGAGERDAEEIKVQPFFRTTNWQALLARTVQPPFVPTLCGPADLRYFEGEFTSLP 850

  Fly  1863 VRLT-PIDKEILASMDQKQFHGFTYTN 1888
            ..|| |:.:..|::..|..|..|.:.:
  Rat   851 PTLTPPVPRRSLSARQQAAFRDFDFVS 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	128/260 (49%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	149/323 (46%)
Pkn3	XP_006233834.1	HR1_PKN_1	14..79	CDD:212012
		HR1	95..168	CDD:294066
		HR1	168..>226	CDD:294066
		C2	326..413	CDD:301316
		PTZ00263	549..873	CDD:140289	151/325 (46%)
		PKc_like	553..877	CDD:304357	151/325 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343119
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930