Protein Alignment Pkcdelta and Prkcb

DIOPT Version :10

• Sequence 1: NP_572797.3
• Gene: Pkcdelta / 32191
• FlyBaseID: FBgn0287828
• Length: 1894
• Species: Drosophila melanogaster
• Sequence 2: NP_036845.3
• Gene: Prkcb / 25023
• RGDID: 3396
• Length: 673
• Species: Rattus norvegicus
• Alignment Length: 518
• Identity: 224/518 - (43%)
• Similarity: 292/518 - (56%)
• Gaps: 49/518 - (9%)

  Fly  1373 DPHKKIKIDTTNKCYVKEEAPRYPLVATPRPLWKREKIVYSDENTDDESGSEEGSGGSLDEDSDD 1437
            ||:.|:|:....|...|::..  .:..:..|.|.........|:..|...|.|      ..|.|.
  Rat   193 DPYVKLKLIPDPKSESKQKTK--TIKCSLNPEWNETFRFQLKESDKDRRLSVE------IWDWDL 249

  Fly  1438 ESGGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVLDSSNSSGSNAGTLSVPSAGSGSGGGAST 1502
            .|..:...|.|...|.        :.|||......:|........|     ||....||.|....
  Rat   250 TSRNDFMGSLSFGISE--------LQKAGVDGWFKLLSQEEGEYFN-----VPVPPEGSEGNEEL 301

  Fly  1503 SSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSYTYSQFQKSGRFTAPATVIPRFKNYSVDDFH 1567
            .......::.        :|..||..     :|:.|.|:|..:|.       ..|.|   :.||:
  Rat   302 RQKFERAKIG--------QGTKAPEE-----KTANTISKFDNNGN-------RDRMK---LTDFN 343

  Fly  1568 FLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFC 1632
            ||.||||||||||:|:|.:.|...||:|.||||||::||||:.|::|::||||..|.|:|..|..
  Rat   344 FLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHS 408

  Fly  1633 TFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVL 1697
            .|||...|:|||||:||||||:|||:.|||.|..|.||.|||..||.||..|||||||||||||:
  Rat   409 CFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 473

  Fly  1698 LDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQ 1762
            ||.|||::||||||||..|:...|..:|||||||:|||||..:.|.::||||:|||||||||.||
  Rat   474 LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQ 538

  Fly  1763 SPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAG--DIADHIFFR 1825
            :||.|.||||||.||......:|..:|.||..|.|||:.|...||:|.  .|.|  ||.:|.|||
  Rat   539 APFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGC--GPEGERDIKEHAFFR 601

  Fly  1826 PIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTPIDKEILASMDQKQFHGFTYTN 1888
            .|||..||:::|:||:||:. ...:.:.|||.|||....|||.|:|::.::||.:|.||::.|
  Rat   602 YIDWEKLERKEIQPPYKPKA-CGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVN 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	Herpes_BLLF1	<802..1131	CDD:282904
		STKc_nPKC_theta_like	1570..1889	CDD:270744	182/321 (57%)
Prkcb	NP_036845.3	C1_cPKC_rpt1	35..92	CDD:410383
		C1_cPKC_rpt2	102..155	CDD:410386
		C2_PKC_alpha_gamma	159..289	CDD:175992	23/116 (20%)
		STKc_cPKC_beta	341..663	CDD:270767	185/324 (57%)