DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and Akt3

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	NP_035915.3	Gene:	Akt3 / 23797	MGIID:	1345147	Length:	479	Species:	Mus musculus

Alignment Length:	335	Identity:	151/335 - (45%)
Similarity:	219/335 - (65%)	Gaps:	7/335 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly  1559 KNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTK 1623
            |..:::||.:|.:||||:||||:|...:.:..|||:|.|||:|::..|:|..||.|.:||. .|:
Mouse   141 KRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK-NTR 204

  Fly  1624 HPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIY 1688
            ||:|..|..:|||:..|.|||||:|||:|.||:.....|||:|.|||||||:|.|.:||...|:|
Mouse   205 HPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVY 269

  Fly  1689 RDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGV 1753
            |||||:|::||.:||::|.|||:||..|....|..:|||||:|:|||:::...|.:.||||..||
Mouse   270 RDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGV 334

  Fly  1754 LLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAGDI 1818
            ::|||:.|:.||...|.::||..|..|...||..:|::|..:|.|||.||..||:|.....|.:|
Mouse   335 VMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI 399

  Fly  1819 ADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTP---IDKEILASMDQKQ 1880
            ..|.||..::|..:..:::.|||||||....||:|||..||.:.:.:||   .|.:.:..||.::
Mouse   400 MRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDDDGMDGMDNER 464

  Fly  1881 ---FHGFTYT 1887
               |..|:|:
Mouse   465 RPHFPQFSYS 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	124/257 (48%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	147/324 (45%)
Akt3	NP_035915.3	PH_PKB	4..110	CDD:269947
		STKc_PKB_gamma	132..479	CDD:270745	151/335 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..479		8/30 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910