DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and SGK3

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	NP_001028750.1	Gene:	SGK3 / 23678	HGNCID:	10812	Length:	496	Species:	Homo sapiens

Alignment Length:	333	Identity:	144/333 - (43%)
Similarity:	200/333 - (60%)	Gaps:	11/333 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly  1565 DFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLCH 1629
            ||.||.|:|||||||||||:.:....:||:|.|:|.:||...:....:.||.||....|||:|..
Human   161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVG 225

  Fly  1630 LFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLD 1694
            |..:|||...|:||::::|||:|.||:|....|.|.|||||.|||.|.|.:||...|:|||||.:
Human   226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPE 290

  Fly  1695 NVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEML 1759
            |:|||..|||.:.|||:||..|.:..|..:|||||:|:|||:|:.:.|:..||||..|.:|||||
Human   291 NILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEML 355

  Fly  1760 IGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAGDIADHIFF 1824
            .|..||...|..|::.:|.::.......:|..|..||:.|||||...|:|:: ....:|.:|.||
Human   356 YGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAK-EDFLEIQNHPFF 419

  Fly  1825 RPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTP--------IDKEILASMDQKQF 1881
            ..:.|..|.:::|.|||.|.|..|.|.:.||..||.|.|..:.        ::..:|.:.|  .|
Human   420 ESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD--AF 482

  Fly  1882 HGFTYTNP 1889
            .||:|..|
Human   483 VGFSYAPP 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	118/257 (46%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	139/326 (43%)
SGK3	NP_001028750.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PX_CISK	12..120	CDD:132780
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..156
		STKc_SGK3	165..490	CDD:270755	140/327 (43%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910