DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkcdelta and Pkn2

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	XP_038957612.1	Gene:	Pkn2 / 207122	RGDID:	620146	Length:	989	Species:	Rattus norvegicus

Alignment Length:	1114	Identity:	297/1114 - (26%)
Similarity:	460/1114 - (41%)	Gaps:	250/1114 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   883 PTKDSPTRKIVTPTTPQAKVETPTKD--SPTRKI-VTPTTPQAKVETPTKDSPTRKIATPTTPQA 944
            |.||||...:    .|......|..:  |..:|: .:.|..|.|:: ..||...|:|....  :.
  Rat    11 PEKDSPCNSV----RPGDSRPLPFSENVSAVQKLDFSDTIVQQKLD-DVKDRIKREIRKEL--KI 68

  Fly   945 KAAASTTSPLTTPQKTPQVKAATDESKSTPAAPKTTMAKISMTTMAGTTVAEAGKTISPKGLK-Q 1008
            |..|.....:||.:|                    .:|.:.      ..:.::.|.:.....| |
  Rat    69 KEGAENLRKVTTDKK--------------------NLAYVD------NILKKSNKKLEELHHKLQ 107

  Fly  1009 SGNA---VAMPTATPTTPNTPTTATGKSK----------LNETAGPKINSGQPAKSPEQQQATAA 1060
            ..||   |:.|..:...|.||.|....|:          |.:....::...|.|::..|..:...
  Rat   108 ELNAHIVVSDPEDSADCPRTPDTPNSDSRSSTSNNRLMALQKQLDIELKVKQGAENMIQMYSNGP 172

  Fly  1061 AVETKINKTT-----DKEQQQQQQQQQQQQAQQQQQQLIDTAATLVPQTETKTK------LTEAA 1114
            :.:.|::.|.     |.:.:.:..:.|..||.|..:...|.|..::...|.:.:      ..|.|
  Rat   173 SKDRKLHGTAQQLLQDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFA 237

  Fly  1115 EPTGKSKVQSPNTTKPKSAGKTNVGKKKAATPAAAAAAAAAAAPAAATATEAVTALSES----NV 1175
            ...|...|.       |..|...|..:||                   .:||....:||    ::
  Rat   238 VAEGAKNVM-------KLLGSGKVTDRKA-------------------LSEAQARFNESSQKLDL 276

  Fly  1176 TPINADQFITLAPTKAAKTSPNKQQALQLQQQHEEQQRQQ----QQQATNASSPAATGDATTTPT 1236
            ...:.:|.:...|....|:|...:: |.|........||.    |.|.:..|.|||   .|.|..
  Rat   277 LKYSLEQRLNELPKNHPKSSVVIEE-LSLVASPTLSPRQSMLSTQNQYSTLSKPAA---LTGTLE 337

  Fly  1237 TITIGVAAV--NVAAVAVVASAAAAAATDAAADATTSLSSNNSCGEGVGNNLSKFATVSNLAQCL 1299
            ...:|...:  ||...: .|::.|......:.:.::.:|..:....|...||.|...:||
  Rat   338 VRLMGCQDILENVPGRS-KATSVALPGWSPSENRSSFMSRTSKSKSGSSRNLLKTDDLSN----- 396

  Fly  1300 RDVDA--ELDDYI-------PSSAENSQEDDDDDDDGSGSSS-----DDYSSVDGCA-------- 1342
             ||.|  :||:.:       |.|.::..:....:.|.|....     .|:.|:  ||
  Rat   397 -DVCAVLKLDNTVVGQTIWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSL--CAVKFLRLED 458

  Fly  1343 --------------------------NLSASMKKKLRKEKK---KQKAKAAAAAEAKRFDPHKKI 1378
                                      |.....:.||:::||   ||:.|....|      |...|
  Rat   459 FLDNQRHGMCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRA------PQMNI 517

  Fly  1379 KIDTTNKCYVKEE----------APRYPLVATPRPLWKREKIVYSDENTDD-ESGSEEGSGGSLD 1432
            .|.|..: .|:..          :|:.|:.||         :...|..|.: ...:.:.:...||
  Rat   518 NIATWGR-LVRRAIPTVNHSGTFSPQTPVPAT---------VPVVDARTPELAPPASDSTVTKLD 572

  Fly  1433 EDSDDESGGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVLDSSNS------SGSNAGTLSVPS 1491
            .|.:.|:  ......:||....|..:...|.......:.||.|..|.      ...:...|::|.
  Rat   573 FDLEPEA--PPAPPRASSLGEIDDSSELRVLDIPGQGSETVFDIENDRNNMRPKSKSEYELNIPD 635

  Fly  1492 AGSGSGGGASTSSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSYTYSQFQKSGRFTAPATVIP 1556
                                   |:.|.:..|.        ||...:..:||
  Rat   636 -----------------------SSRSCWSVGE--------LEDKRSQQRFQ------------- 656

  Fly  1557 RFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLAL- 1620
                :::.||...||||:|.||||||||.:.|...:|||.|||..::..|:|||.:.|:::...
  Rat   657 ----FNLQDFRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV 717

  Fly  1621 -GTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKK 1684
             ..:||:|.:||..|||:.|:.|||||..|||||.|| .:..|||.||.||.|.::.||::||:.
  Rat   718 NSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHI-HTDVFSEPRAVFYAACVVLGLQYLHEH 781

  Fly  1685 GIIYRDLKLDNVLLDYEGHVRIADFGMCKLQI-YLDKTADSFCGTPDYMAPEIIKGEKYNQNVDW 1748
            .|:||||||||:|||.||.|:|||||:||..: |.|:|: :|||||:::|||::....|.:.|||
  Rat   782 KIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTS-TFCGTPEFLAPEVLTETSYTRAVDW 845

  Fly  1749 WSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYS 1813
            |..|||:||||:|:|||.|.||:|:|.||.|:...:|.::|.||..|::.||.::..:|:|:...
  Rat   846 WGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGAGEK 910

  Fly  1814 PAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLT-PIDKEILASMD 1877
            .|.|:..|.|||..||..|..::::|||.|.::...|...||..||.|...|| |.:..||...:
  Rat   911 DAEDVKKHPFFRLTDWSALLDKKVKPPFVPTIRGREDVSNFDDEFTSEAPILTPPREPRILLEEE 975

  Fly  1878 QKQFHGFTY 1886
            |:.|..|.|
  Rat   976 QEMFRDFDY 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	128/260 (49%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	152/321 (47%)
Pkn2	XP_038957612.1	HR1_PKN_1	48..113	CDD:212012	17/93 (18%)
		HR1_PKN2_2	134..207	CDD:212021	12/72 (17%)
		HR1_PKN2_3	215..288	CDD:212025	15/98 (15%)
		C2_PKN-like	395..478	CDD:176069	15/90 (17%)
		STKc_PKN	662..987	CDD:270741	153/325 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343101
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840