Protein Alignment Pkcdelta and Pkn2

DIOPT Version :10

• Sequence 1: NP_572797.3
• Gene: Pkcdelta / 32191
• FlyBaseID: FBgn0287828
• Length: 1894
• Species: Drosophila melanogaster
• Sequence 2: NP_001099225.2
• Gene: Pkn2 / 207122
• RGDID: 620146
• Length: 983
• Species: Rattus norvegicus
• Alignment Length: 967
• Identity: 269/967 - (27%)
• Similarity: 415/967 - (42%)
• Gaps: 207/967 - (21%)

  Fly  1020 PTTPNTPTTATGKS-------KLNETAGPKINSGQPAKSPEQQQATAAAVETKINKTT-----DK 1072
            |.||:||.:.:..|       .|.:....::...|.|::..|..:...:.:.|::.|.     |.
  Rat   119 PRTPDTPNSDSRSSTSNNRLMALQKQLDIELKVKQGAENMIQMYSNGPSKDRKLHGTAQQLLQDS 183

  Fly  1073 EQQQQQQQQQQQQAQQQQQQLIDTAATLVPQTETKTK------LTEAAEPTGKSKVQSPNTTKPK 1131
            :.:.:..:.|..||.|..:...|.|..::...|.:.:      ..|.|...|...|.       |
  Rat   184 KTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVM-------K 241

  Fly  1132 SAGKTNVGKKKAATPAAAAAAAAAAAPAAATATEAVTALSES----NVTPINADQFITLAPTKAA 1192
            ..|...|..:||                   .:||....:||    ::...:.:|.:...|....
  Rat   242 LLGSGKVTDRKA-------------------LSEAQARFNESSQKLDLLKYSLEQRLNELPKNHP 287

  Fly  1193 KTSPNKQQALQLQQQHEEQQRQQ----QQQATNASSPAATGDATTTPTTITIGVAAV--NVAAVA 1251
            |:|...:: |.|........||.    |.|.:..|.|||   .|.|.....:|...:  ||...:
  Rat   288 KSSVVIEE-LSLVASPTLSPRQSMLSTQNQYSTLSKPAA---LTGTLEVRLMGCQDILENVPGRS 348

  Fly  1252 VVASAAAAAATDAAADATTSLSSNNSCGEGVGNNLSKFATVSNLAQCLRDVDA--ELDDYI---- 1310
             .|::.|......:.:.::.:|..:....|...||.|...:||      ||.|  :||:.:
  Rat   349 -KATSVALPGWSPSENRSSFMSRTSKSKSGSSRNLLKTDDLSN------DVCAVLKLDNTVVGQT 406

  Fly  1311 ---PSSAENSQEDDDDDDDGSGSSS-----DDYSSVDGCA------------------------- 1342
               |.|.::..:....:.|.|....     .|:.|:  ||
  Rat   407 IWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSL--CAVKFLRLEDFLDNQRHGMCLYLEPQG 469

  Fly  1343 ---------NLSASMKKKLRKEKK---KQKAKAAAAAEAKRFDPHKKIKIDTTNKCYVKEE---- 1391
                     |.....:.||:::||   ||:.|....|      |...|.|.|..: .|:..
  Rat   470 TLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRA------PQMNINIATWGR-LVRRAIPTV 527

  Fly  1392 ------APRYPLVATPRPLWKREKIVYSDENTDD-ESGSEEGSGGSLDEDSDDESGGEECSSTSS 1449
                  :|:.|:.||         :...|..|.: ...:.:.:...||.|.:.|:  ......:|
  Rat   528 NHSGTFSPQTPVPAT---------VPVVDARTPELAPPASDSTVTKLDFDLEPEA--PPAPPRAS 581

  Fly  1450 SASSEDLDAVAMVTKAGSSNATTVLDSSNS------SGSNAGTLSVPSAGSGSGGGASTSSSPSI 1508
            |....|..:...|.......:.||.|..|.      ...:...|::|.
  Rat   582 SLGEIDDSSELRVLDIPGQGSETVFDIENDRNNMRPKSKSEYELNIPD----------------- 629

  Fly  1509 IRMSTCSNDSGFEGGTAPSSPKKMLETSYTYSQFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLG 1573
                  |:.|.:..|.        ||...:..:||                 :::.||...||||
  Rat   630 ------SSRSCWSVGE--------LEDKRSQQRFQ-----------------FNLQDFRCCAVLG 663

  Fly  1574 KGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLAL--GTKHPYLCHLFCTFQT 1636
            :|.||||||||.:.|...:|||.|||..::..|:|||.:.|:::...  ..:||:|.:||..|||
  Rat   664 RGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQT 728

  Fly  1637 ESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYE 1701
            :.|:.|||||..|||||.|| .:..|||.||.||.|.::.||::||:..|:||||||||:|||.|
  Rat   729 KEHVCFVMEYAAGGDLMMHI-HTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTE 792

  Fly  1702 GHVRIADFGMCKLQI-YLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPF 1765
            |.|:|||||:||..: |.|:|: :|||||:::|||::....|.:.||||..|||:||||:|:|||
  Rat   793 GFVKIADFGLCKEGMGYGDRTS-TFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPF 856

  Fly  1766 SGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAGDIADHIFFRPIDWG 1830
            .|.||:|:|.||.|:...:|.::|.||..|::.||.::..:|:|:....|.|:..|.|||..||.
  Rat   857 PGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGAGEKDAEDVKKHPFFRLTDWS 921

  Fly  1831 LLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLT-PIDKEILASMDQKQFHGFTY 1886
            .|..::::|||.|.::...|...||..||.|...|| |.:..||...:|:.|..|.|
  Rat   922 ALLDKKVKPPFVPTIRGREDVSNFDDEFTSEAPILTPPREPRILLEEEQEMFRDFDY 978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	Herpes_BLLF1	<802..1131	CDD:282904	24/128 (19%)
		STKc_nPKC_theta_like	1570..1889	CDD:270744	152/321 (47%)
Pkn2	NP_001099225.2	HR1_PKN_1	42..107	CDD:212012
		HR1_PKN2_2	128..201	CDD:212021	12/72 (17%)
		HR1_PKN2_3	209..282	CDD:212025	15/98 (15%)
		C2_PKN-like	389..472	CDD:176069	15/90 (17%)
		STKc_PKN	656..981	CDD:270741	153/325 (47%)