DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and Prkci

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	NP_032883.2	Gene:	Prkci / 18759	MGIID:	99260	Length:	595	Species:	Mus musculus

Alignment Length:	384	Identity:	167/384 - (43%)
Similarity:	232/384 - (60%)	Gaps:	26/384 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly  1516 NDSGFEGGTAPSSPKKMLETSYTYSQFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKV 1580
            |.|..|........|:.:.|       ::||:.::         :..:.||..|.|:|:||:.||
Mouse   219 NPSSHESLDQVGEEKEAMNT-------RESGKASS---------SLGLQDFDLLRVIGRGSYAKV 267

  Fly  1581 LLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHLFFVME 1645
            ||..|:.|...||:|.:||::|.:|:|:|....|:.|....:.||:|..|...|||||.||||:|
Mouse   268 LLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIE 332

  Fly  1646 YLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFG 1710
            |:||||||||:|...:..||.||||.|||...|.:||::|||||||||||||||.|||:::.|:|
Mouse   333 YVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYG 397

  Fly  1711 MCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPF---SGCD--- 1769
            |||..:....|..:|||||:|:||||::||.|..:||||:.|||::||:.|:|||   ...|
Mouse   398 MCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPD 462

  Fly  1770 ---EDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQ-YSPAGDIADHIFFRPIDWG 1830
               ||.||..|..:....|..:|.:|..:||..|.||..:|:|.. .:...||..|.|||.:||.
Mouse   463 QNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWD 527

  Fly  1831 LLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTPIDKEILASMDQKQFHGFTYTNP 1889
            ::|::|:.|||||.:........||..||.|.|:|||.|.:|:..:||.:|.||.|.||
Mouse   528 MMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	128/267 (48%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	155/328 (47%)
Prkci	NP_032883.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Regulatory domain. /evidence=ECO:0000250	2..252		7/48 (15%)
		Required for interaction with RAB2. /evidence=ECO:0000250	2..28
		PB1_aPKC	26..108	CDD:99725
		Interaction with PARD6A. /evidence=ECO:0000250	72..91
		Pseudosubstrate	125..134
		C1_1	141..193	CDD:278556
		STKc_aPKC_iota	232..595	CDD:270769	164/371 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839285
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840