DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and Prkch

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	NP_032882.2	Gene:	Prkch / 18755	MGIID:	97600	Length:	683	Species:	Mus musculus

Alignment Length:	420	Identity:	203/420 - (48%)
Similarity:	264/420 - (62%)	Gaps:	39/420 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1481 GSNAGTLSVPSAGSGSGGGASTSSSPSIIRMSTCSNDSGFEG-----GTAPSSPKKMLETSYTYS 1540
            |.||..|:...||.|...| :.|.:..:|..||... .|.||     |...:|
Mouse   296 GVNAVELAKTLAGMGLQPG-NISPTSKLISRSTLRR-QGKEGSKEGNGIGVNS------------ 346

  Fly  1541 QFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLED 1605
                |.||             .:|:|.|:.||||||||||:||.:::|...||:|.|||||:|:|
Mouse   347 ----SSRF-------------GIDNFEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQD 394

  Fly  1606 DDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFY 1670
            |||:.|:.|:::|:|...||:|..|||.|||...||||||::||||||||||:|.||.|.|||||
Mouse   395 DDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFY 459

  Fly  1671 GAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPE 1735
            .|||||.|.|||:||||||||||||||||:|||.::|||||||..|....|..:|||||||:|||
Mouse   460 AAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPE 524

  Fly  1736 IIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLL 1800
            |::...|...||||:.||||||||.|.:||...:||:||.:|.|:...:|.::..:||||||..:
Mouse   525 ILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFM 589

  Fly  1801 EKDYTKRIGSQYSPAG--DIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERV 1863
            .|:.|.|:|| .:..|  :|..|.||:.|||..|..||:||||:|::|...|...||..|.:|..
Mouse   590 TKNPTMRLGS-LTQGGEHEILRHPFFKEIDWAQLNHRQLEPPFRPRIKSREDVSNFDPDFIKEEP 653

  Fly  1864 RLTPIDKEILASMDQKQFHGFTYTNPHITL 1893
            .|||||:..|..::|.:|..|:|.:|.:.|
Mouse   654 VLTPIDEGHLPMINQDEFRNFSYVSPELQL 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	151/259 (58%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	178/320 (56%)
Prkch	NP_032882.2	C2_PKC_epsilon	8..140	CDD:175981
		C1_1	172..222	CDD:365894
		C1_1	246..296	CDD:365894	203/420 (48%)
		STKc_nPKC_eta	359..681	CDD:270742	179/322 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839312
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.880