DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and Prkcd

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	NP_001297611.1	Gene:	Prkcd / 18753	MGIID:	97598	Length:	700	Species:	Mus musculus

Alignment Length:	444	Identity:	227/444 - (51%)
Similarity:	290/444 - (65%)	Gaps:	51/444 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1457 DAVAMVTKAGSSNATTVLDSSNSSGSNAGTLSVPS-AGSGSGGGASTS-----SSPSIIR----M 1511
            :|:..||:..|..    ||::.|.|...|....|. :||...|.|.:.     |.||..:    .
Mouse   289 EALNQVTQRSSRK----LDTTESVGIYQGFEKKPEVSGSDILGEAGSHISLKLSFPSRAKEKDSS 349

  Fly  1512 STCSNDSGFEGGTAPSSPKKMLETSYTYSQ-FQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKG 1575
            .||.|:.                   ||.: ::.|.|.|             :::|.|..|||||
Mouse   350 ETCDNNG-------------------TYGKIWEGSTRCT-------------LENFTFQKVLGKG 382

  Fly  1576 SFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHL 1640
            ||||||||||:....|:|||||||||||.||||:.|::|::||||..:.|:|.||.|||||:.||
Mouse   383 SFGKVLLAELKGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFLTHLICTFQTKDHL 447

  Fly  1641 FFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVR 1705
            |||||:|||||||||||:.|||...||.||.||||.||:|||.|||||||||||||:||.:||::
Mouse   448 FFVMEFLNGGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIK 512

  Fly  1706 IADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDE 1770
            ||||||||..|:.:..|.:|||||||:||||::|.||:.:||||||||||||||||||||.|.||
Mouse   513 IADFGMCKENIFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEMLIGQSPFHGDDE 577

  Fly  1771 DELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKR 1835
            ||||.||..:.|.:|.:|:.|:..|::.|.|:|..||:|    ..|:|..|.||:.|:|.|||||
Mouse   578 DELFESIRVDTPHYPRWITKESKDIMEKLFERDPDKRLG----VTGNIRIHPFFKTINWSLLEKR 638

  Fly  1836 QIEPPFKPQVKHPLDTQYFDRVFTRERVRLTPIDKEILASMDQKQFHGFTYTNP 1889
            ::||||||:||.|.|...||..|..|:.:|:..||.::.||||:.||||::.||
Mouse   639 KVEPPFKPKVKSPSDYSNFDPEFLNEKPQLSFSDKNLIDSMDQEAFHGFSFVNP 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	166/257 (65%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	198/318 (62%)
Prkcd	NP_001297611.1	C1_1	159..208	CDD:365894
		C1_1	231..281	CDD:365894
		PKc_like	377..692	CDD:389743	198/318 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I1118
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55963
Inparanoid	1	1.050	611	1.000	Inparanoid score	I916
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45425
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	1	1.000	-	-		otm42516
orthoMCL	1	0.900	-	-		OOG6_105998
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	14.010