DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and Prkca

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	XP_036012317.1	Gene:	Prkca / 18750	MGIID:	97595	Length:	688	Species:	Mus musculus

Alignment Length:	539	Identity:	226/539 - (41%)
Similarity:	295/539 - (54%)	Gaps:	76/539 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1373 DPHKKIKI--DTTNKCYVKEEAPRYPLVATPRPLWKRE---KIVYSDENTDDESGSEEGSGGSLD 1432
            ||:.|:|:  |..|:...|.:..|    :|..|.|...   |:..||:   |...|.|      .
Mouse   193 DPYVKLKLIPDPKNESKQKTKTIR----STLNPQWNESFTFKLKPSDK---DRRLSVE------I 244

  Fly  1433 EDSDDESGGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVLDSSNSSGSNAGTLSVPSAGSGSG 1497
            .|.|..:..:...|.|...|.        :.|..:|....:|:.......|     ||.......
Mouse   245 WDWDRTTRNDFMGSLSFGVSE--------LMKMPASGWYKLLNQEEGEYYN-----VPIPEGDEE 296

  Fly  1498 GGASTSSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSYTYSQFQKSGRFTAPATVIPRFKNYS 1562
            |...........::....|..     .:||..:|.                  |:..:.|.|
Mouse   297 GNMELRQKFEKAKLGPAGNKV-----ISPSEDRKQ------------------PSNNLDRVK--- 335

  Fly  1563 VDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYL 1627
            :.||:||.||||||||||:||:.:.|...||||.||||||::||||:.|::|::||||..|.|:|
Mouse   336 LTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFL 400

  Fly  1628 CHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLK 1692
            ..|...|||...|:|||||:||||||:|||:.|:|.|.:|.||.|||..||.||||:||||||||
Mouse   401 TQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLK 465

  Fly  1693 LDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYE 1757
            ||||:||.|||::||||||||..:....|..:|||||||:|||||..:.|.::||||::||||||
Mouse   466 LDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYE 530

  Fly  1758 MLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAG--DIAD 1820
            ||.||.||.|.||||||.||......:|..:|.||..|.|||:.|...||:|.  .|.|  |:.:
Mouse   531 MLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGC--GPEGERDVRE 593

  Fly  1821 HIFFRPIDWGLLEKRQIEPPFKPQV-----KHPLD----------TQYFDRVFTRERVRLTPIDK 1870
            |.|||.|||..||.|:|:|||||:|     .|.|.          .:.||:.|||.:..|||.|:
Mouse   594 HAFFRRIDWEKLENREIQPPFKPKVTFCTKMHWLQWASRPSCGKGAENFDKFFTRGQPVLTPPDQ 658

  Fly  1871 EILASMDQKQFHGFTYTNP 1889
            .::|::||..|.||:|.||
Mouse   659 LVIANIDQSDFEGFSYVNP 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	153/259 (59%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	184/335 (55%)
Prkca	XP_036012317.1	C1_cPKC_rpt1	35..92	CDD:410383
		C1_cPKC_rpt2	102..155	CDD:410386
		C2_PKC_alpha_gamma	159..289	CDD:175992	26/121 (21%)
		STKc_cPKC_alpha	328..684	CDD:270766	192/355 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839308
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.880