DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and pkc-2

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	NP_001359883.1	Gene:	pkc-2 / 181166	WormBaseID:	WBGene00004033	Length:	753	Species:	Caenorhabditis elegans

Alignment Length:	556	Identity:	217/556 - (39%)
Similarity:	296/556 - (53%)	Gaps:	105/556 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1373 DPHKKIK-IDTTNKCYVKEEAPRYPLVATPRPLWKRE---KIVYSDE--------------NTDD 1419
            ||:.|.| |...:.|..|::..  .|.||..|.|...   |::..|:              :.:|
Worm   266 DPYVKCKLIPEDSGCKSKQKTK--TLRATLNPQWNETFTYKLLPGDKDRRLSIEVWDWDRTSRND 328

  Fly  1420 ESGS---------EEGSGGSLDEDSDDESGGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVLD 1475
            ..||         :|.:.|.....|.:|  ||..:...:....||::   .|.|..:.|..| .|
Worm   329 FMGSLSFGISELMKEAASGWYKLLSAEE--GEFYNINITPEYDEDME---KVRKKMNENFIT-RD 387

  Fly  1476 SSNSSGSNAGTLSVPSAGSGSGGGAST----SSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLETS 1536
            :|:|...:      |:|..     |||    ||:.::|:.|
Worm   388 NSSSKPKD------PAAPR-----ASTLPLGSSNHNVIKAS------------------------ 417

  Fly  1537 YTYSQFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDV 1601
                                        ||:||.||||||||||||.|.:.|...:|||.|||||
Worm   418 ----------------------------DFNFLTVLGKGSFGKVLLGEQKTTKELFAIKVLKKDV 454

  Fly  1602 VLEDDDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEER 1666
            :::||||:.|:.|::||||..|..:|..|...|||...|:||||::||||||:.||:.|:|.|..
Worm   455 IIQDDDVECTMTEKRVLALPEKPSFLVALHSCFQTMDRLYFVMEFVNGGDLMYQIQQVGKFKEPV 519

  Fly  1667 ARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDY 1731
            |.||.|||..||.|||.|||||||||||||:|:.:||::|.||||||..|:.|.|..:|||||||
Worm   520 AVFYAAEIAVGLFFLHSKGIIYRDLKLDNVMLERDGHIKITDFGMCKENIFGDATTKTFCGTPDY 584

  Fly  1732 MAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGIL 1796
            :|||||..:.|.::||||::||||:|||.||.||.|.||||||.:|......:|..:|.||..:.
Worm   585 IAPEIILYQPYGKSVDWWAYGVLLFEMLAGQPPFDGEDEDELFTAITEHNVSYPKSLSKEAVSLC 649

  Fly  1797 KGLLEKDYTKRI---GSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVF 1858
            |.||.|:.:||:   |...|.:.||.:|.|||.|||..:|.|||:|||||::|....|:.||..|
Worm   650 KALLIKNPSKRLGCTGDDESASRDIKEHPFFRRIDWFKIETRQIQPPFKPKLKTDRSTENFDHSF 714

  Fly  1859 TRERVRLTPIDKEILASMDQKQFHGFTYTNPHITLD 1894
            .:...::||.|.|:|.::...:|..|::.||....|
Worm   715 LKLPTKMTPPDWEVLENLKGDEFSNFSFVNPFYVKD 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	145/260 (56%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	169/321 (53%)
pkc-2	NP_001359883.1	C1_1	110..160	CDD:365894
		C1_1	175..225	CDD:365894
		C2_PKC_alpha_gamma	232..362	CDD:175992	23/99 (23%)
		STKc_cPKC	422..744	CDD:270739	170/321 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950