DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and pkc-1

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	NP_001256396.1	Gene:	pkc-1 / 179649	WormBaseID:	WBGene00004032	Length:	763	Species:	Caenorhabditis elegans

Alignment Length:	530	Identity:	205/530 - (38%)
Similarity:	283/530 - (53%)	Gaps:	114/530 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1371 RFDPHKKIKIDTTNKCYVK-----EEAPRYPLVATPRPLWKREK-IVYSDENTDDESGSEEGSGG 1429
            :.:.||:.:.:..|.|.:.     .|..:..|......:..::| .:.:|.:||....|...:.|
Worm   339 KLNVHKRCQRNVANNCGINAKQMAAELAQLGLTGDKMSIRSKKKPSIMTDTSTDISGSSNSENSG 403

  Fly  1430 SLDEDSDDESGGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVLDSSNSSGSNAGTLSVPSAGS 1494
            .|.:.|:|:||     :|||.::|:                                  ||
Worm   404 YLQQISEDDSG-----TTSSRSASK----------------------------------VP---- 425

  Fly  1495 GSGGGASTSSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSYTYSQFQKSGRFTAPATVIPRFK 1559
                                       |||
Worm   426 ---------------------------GGT----------------------------------- 428

  Fly  1560 NYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKH 1624
             .|:.||.|:.||||||||||:|||.:.|...||||.|||||:::||||:.|:.|:::|:|..||
Worm   429 -LSIHDFTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKH 492

  Fly  1625 PYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYR 1689
            |:|..|..:|||...|||||||:|||||||.||.:.:|.|.|||||.||:...|:|||:..:|||
Worm   493 PFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDESRARFYAAEVTCALQFLHRNDVIYR 557

  Fly  1690 DLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVL 1754
            ||||||:|||.|||.|:|||||||..|..|....:|||||||:||||::..:|..:||||:.|||
Worm   558 DLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWALGVL 622

  Fly  1755 LYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAGD-- 1817
            :|||:.||.||...:||:||.:|.|:...:||::|.||..|||..:.|:..||:|...|..|:
Worm   623 MYEMMAGQPPFEADNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGGEDA 687

  Fly  1818 IADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTPIDKEILASMDQKQFH 1882
            |..|.|||.|||..||.||::|||||::|...|...||..||:|...|||.|..::.:::|.:|.
Worm   688 IRAHPFFREIDWDALESRQVKPPFKPKIKSKRDANNFDSDFTKEEPVLTPSDPAVVRAINQDEFR 752

  Fly  1883 GFTYTNPHIT 1892
            ||::.|||.|
Worm   753 GFSFINPHFT 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	143/259 (55%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	171/320 (53%)
pkc-1	NP_001256396.1	C2_PKC_epsilon	59..188	CDD:175981
		C1_1	227..279	CDD:278556
		C1_1	305..357	CDD:278556	4/17 (24%)
		S_TKc	434..694	CDD:214567	143/259 (55%)
		STKc_nPKC_epsilon	438..758	CDD:270743	171/319 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950