DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkcdelta and tpa-1

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	NP_001379590.1	Gene:	tpa-1 / 176825	WormBaseID:	WBGene00006599	Length:	704	Species:	Caenorhabditis elegans

Alignment Length:	428	Identity:	212/428 - (49%)
Similarity:	274/428 - (64%)	Gaps:	20/428 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly  1477 SNSSGSNAGTLSVPSAGSGSGGGASTSSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSYTYS- 1540
            ||..|.|...||........|..|:.|..|:|..:. .:.::....|:.|:..|.:.: |:.||
Worm   284 SNLCGVNQKQLSEMYHEIKRGTHATASCPPNIANLH-LNGETSKNNGSLPNKLKNLFK-SHQYSV 346

  Fly  1541 QFQKS---------GRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKC 1596
            :.||.         |....|.      |.:::..|:.|.||||||||||:|.||:....:||:||
Worm   347 EEQKETDEYMDNIWGGGDGPV------KKFALPHFNLLKVLGKGSFGKVMLVELKGKNEFYAMKC 405

  Fly  1597 LKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGR 1661
            |||||:|||||.:.|.|||:||.|.::.|:||.|||:|||..:||||||||||||||.|||:..:
Worm   406 LKKDVILEDDDTECTYIERRVLILASQCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKK 470

  Fly  1662 FSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDK-TADSF 1725
            |.|.|.|||..||:..|:|||...||||||||||||||.:||:::|||||.|.::..:. .|.:|
Worm   471 FDEARTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTF 535

  Fly  1726 CGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISA 1790
            ||||||::||||||:.||:.||:||||||:||||:|||||.|..|||||.||.||.|:||..||.
Worm   536 CGTPDYISPEIIKGQLYNEAVDFWSFGVLMYEMLVGQSPFHGEGEDELFDSILNERPYFPKTISK 600

  Fly  1791 EATGILKGLLEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFD 1855
            ||...|..|.:::...|:|....|.|.|..|.|||.:||...|.||:.|||||.:|...|...||
Worm   601 EAAKCLSALFDRNPNTRLGMPECPDGPIRQHCFFRGVDWKRFENRQVPPPFKPNIKSNSDASNFD 665

  Fly  1856 RVFTRERVRLTPI-DKEILASMDQKQFHGFTYTNPHIT 1892
            ..||.|:..|||: ||.:|||:|.:.|..|:|||||.:
Worm   666 DDFTNEKAALTPVHDKNLLASIDPEAFLNFSYTNPHFS 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	154/258 (60%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	185/320 (58%)
tpa-1	NP_001379590.1	C1_nPKC_theta-like_rpt1	159..219	CDD:410384
		C1_nPKC_theta-like_rpt2	238..287	CDD:410387	2/2 (100%)
		STKc_nPKC_theta_like	379..700	CDD:270744	185/320 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157903
Domainoid	1	1.000	310	1.000	Domainoid score	I724
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55963
Inparanoid	1	1.050	602	1.000	Inparanoid score	I508
Isobase	1	0.950	-	0	Normalized mean entropy	S1312
OMA	1	1.010	-	-		QHG45425
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	1	1.000	-	-		oto19374
orthoMCL	1	0.900	-	-		OOG6_105998
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890