DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and prkch

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	XP_002939521.2	Gene:	prkch / 100151731	XenbaseID:	XB-GENE-486685	Length:	691	Species:	Xenopus tropicalis

Alignment Length:	413	Identity:	195/413 - (47%)
Similarity:	263/413 - (63%)	Gaps:	31/413 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly  1483 NAGTLSVPSAGSGSGGGASTSSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSY--TYSQFQKS 1545
            |.|..||..|.:.:|.|....:.|  .:..:.|       |:..|....:.|.|.  |.||::
Frog   293 NCGVNSVDLANALAGMGLHPGNIP--FKQHSVS-------GSVDSDSNHLEEDSISNTSSQYK-- 346

  Fly  1546 GRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDS 1610
                           :.:|||.||.||||||||||:||:.:::...||:|.|||||:|:||||:.
Frog   347 ---------------FGIDDFTFLRVLGKGSFGKVMLAKSKESDSLYAVKVLKKDVILQDDDVEC 396

  Fly  1611 TLIERKVLALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEII 1675
            |:.|:::|:|...||:|..|||.|||...||||||::||||||||||:|.||.|.||.||.|||.
Frog   397 TMTEKRILSLACNHPFLTQLFCCFQTLDRLFFVMEFVNGGDLMFHIQKSRRFDEARACFYSAEIT 461

  Fly  1676 SGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGE 1740
            |.|.|||.||:|||||||||||||:|||.::|||||||..|....|..:|||||||:||||::..
Frog   462 SALMFLHDKGVIYRDLKLDNVLLDHEGHCKLADFGMCKEGIREGCTTSTFCGTPDYIAPEILQEM 526

  Fly  1741 KYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYT 1805
            :|...||||:.||||||||.|.:||...:||:||.:|.|:...:|.::|.:|..||:..::|...
Frog   527 QYGPLVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPGWLSQDAVEILQAFMKKKPA 591

  Fly  1806 KRIGSQYSPAGD--IADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTPI 1868
            ||:|| .|..|:  |..|.||:.|:|..|.|:.|||||:|::|...|...||..|.:|...||||
Frog   592 KRLGS-LSLGGEKAILWHPFFKDINWDELNKKTIEPPFRPRIKAREDVSNFDPEFIKEDAVLTPI 655

  Fly  1869 DKEILASMDQKQFHGFTYTNPHI 1891
            |:.:|..::|::|..|:||.|.:
Frog   656 DESLLPLINQEEFRNFSYTAPEL 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	147/259 (57%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	173/320 (54%)
prkch	XP_002939521.2	C2_PKC_epsilon	7..139	CDD:175981
		C1_1	171..221	CDD:365894
		C1_1	245..295	CDD:365894	1/1 (100%)
		STKc_nPKC_eta	356..678	CDD:270742	174/322 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010