Protein Alignment Pkcdelta and lats1

DIOPT Version :10

• Sequence 1: NP_572797.3
• Gene: Pkcdelta / 32191
• FlyBaseID: FBgn0287828
• Length: 1894
• Species: Drosophila melanogaster
• Sequence 2: XP_017949762.1
• Gene: lats1 / 100145677
• XenbaseID: XB-GENE-959763
• Length: 1117
• Species: Xenopus tropicalis
• Alignment Length: 1444
• Identity: 292/1444 - (20%)
• Similarity: 474/1444 - (32%)
• Gaps: 477/1444 - (33%)

  Fly   535 PEGFMKAAPKTTKTSPLKKVNKQQHVNEAQIFTFDEAAIQQQQQVQQQQQQPELPKTEAKVEGVA 599
            |||:.:..|||...|                   :.....:|..::.::....|||
 Frog     7 PEGYRQMRPKTFPAS-------------------NYTGSSRQMLLEIRESLRHLPK--------- 43

  Fly   600 TPKPIRKAIQKSESGEDFWSQIGSRETLYMTNRKKVFNMRQEQQEQLLEEEPPKSPAMPKETKTD 664
             |..:.|..|.|...||  |:.|...|.:.|..|.:..:|              :..:|....:.
 Frog    44 -PSDVAKNEQLSAKAED--SRQGRSTTKFGTYHKALAEIR--------------NSLLPFANVSG 91

  Fly   665 LKTPTTPKLKSEILIELKTTPSIVSTSGKSETQKVPSTPLTPTVVKTNQVEAKKVESMDTSSKAP 729
                ::|:..|||..::...   :..:|..|...:.:         ..|..::.:|       |.
 Frog    92 ----SSPRGNSEINRQMFHD---LQQAGFDEDMVIRA---------LQQTNSRSIE-------AA 133

  Fly   730 ASVISK-----AAESPKLKSATDNNKAKPT-MAKKDLPKLKTAEETKLTITTKATTATPTMDSPK 788
            ...||:     ..:.|.:.:.|.|...||. ..:..:.:.::.:.:|.::..: ...:|..|:
 Frog   134 IEYISRMNYPEMYQEPHIAARTLNASIKPPGNMQNPVNRRQSWKGSKESLIPQ-RLVSPLSDN-- 195

  Fly   789 TPQAKEETSQKTESATTSQIKSDTPIALQIKPQEQMKVAAPTTPQAKVETPPKDSPTRKIVAPTT 853
            ...|.|.:|.:||..........:..| |..|....:|..|..||.:..|||...|..:     |
 Frog   196 VVYASENSSSQTEMGRPLSGSGLSAFA-QALPVNGQRVNPPPPPQMRSVTPPPPPPRGQ-----T 254

  Fly   854 PQAKVETPTKDSPTRKIVTPTT--PQAKVETPTKDSPTRKIVTPTTPQAKVETPTKDSPTRKIVT 916
            |..|..||          .||:  ||     |.:.|...:.:.|........:..:..|...:.|
 Frog   255 PPPKGTTP----------PPTSWEPQ-----PKRYSGNMEFLIPRMNSIPSGSRQEGFPVSSVNT 304

  Fly   917 PTTPQAKVET-PTKDSPTRKIATPTTPQAKAAASTTSPLTTPQKTPQVKAATDESKSTPAAPKTT 980
            .:..|..:.: |....|   |...|:..:|.|.|..|.:.....:.:.
 Frog   305 QSQGQRAINSVPVGRQP---IIMQTSNNSKFAYSGRSGMQNGNGSSEF----------------- 349

  Fly   981 MAKISMTTMAGTTVAEAGKTISPKGLKQSGNAVAMPTATPTTPNTPTTATGKSKLNETAGPKINS 1045
                 :|...|..:  .|:...|            |.:.|..|||.|       |...:|    |
 Frog   350 -----ITNQGGGNI--GGRQPPP------------PYSIPNGPNTTT-------LQVQSG----S 384

  Fly  1046 GQPAKSPEQQQATAAAVETKINKTTDKEQQQQQQQQQQQQAQQQQQQLIDTAATLVPQTETKTKL 1110
            |.|..|.....:.........|:.:..                     ::.....:|...|
 Frog   385 GGPLSSNAYNNSNVPPSMLVSNRNSHN---------------------LEMYNISLPGHPT---- 424

  Fly  1111 TEAAEPTGKSKVQSPNTTKPKSAGKTNVGKKKAA--TPAAAAAAAAAAAPAAATATEAVTALSES 1173
               :.|...|...:|.:.....:.:||:..:..:  .|.|:..|.:.....:||...|||.
 Frog   425 ---SWPQASSTQSAPGSNHDMLSWQTNIPVRSNSFNNPVASWQALSTNTQTSATTVTAVTP---- 482

  Fly  1174 NVTPINADQFITLAPTKAAKT-SPNKQQALQLQQQHEEQQRQQQQQATNASSPAATGDATTTPTT 1237
              :||.       .|.|:.:. .|..|.||                            |.|.||.
 Frog   483 --SPIQ-------QPVKSIRVLKPELQTAL----------------------------APTHPTW 510

  Fly  1238 ITIGVAAVNVAAVAVVASAAAAAATDAAADATTSLSSNNSCGEGVGNNLSKFATVSNLAQCLRDV 1302
            :|..|                               ......|||.:|.|        ||.
 Frog   511 MTPNV-------------------------------QPGPFQEGVSHNTS--------AQL---- 532

  Fly  1303 DAELDDY----IPSSAENSQEDDDDDDDGSGSSSDDYSSVDGCANLSASMKKKLRKEKKKQKAKA 1363
             ||..:|    .|......|::....:.|..||.:|.:.|..|.          ::|.:|.....
 Frog   533 -AEAPNYQGPPPPYPKHLLQQNTTVYEPGLKSSKEDAAGVSTCT----------QEEMEKNTEPT 586

  Fly  1364 AAAAEAKRFDPHKKIKIDTTNKCYVKEEAPRYPLVATPRPLWKREKIVYSDENTDDESGSEEGSG 1428
            ....|.|:                         :..:|.|:.:.::
 Frog   587 TGITEKKQ-------------------------ITTSPVPVRRNKR------------------- 607

  Fly  1429 GSLDEDSDDESGGEECSSTSSSASSEDLDAVAMVTKAGSSNATTVLDSSNSSGSNAGTLSVPSAG 1493
                   |:|....:..|.|..|....::          .:...:|.|.:.
 Frog   608 -------DEERRESQIQSYSPQAFKFFME----------QHVENILKSHHQ-------------- 641

  Fly  1494 SGSGGGASTSSSPSIIRMSTCSNDSGFEG--GTAPSSPKKMLETSYTYSQFQKSGRFTAPATVIP 1556
                         .:.|.....|:....|  ..|....:|||        .||...:.
 Frog   642 -------------RLHRKKQLENEMMRVGLSQEAQDQMRKML--------CQKESNYI------- 678

  Fly  1557 RFKNYSVDDFHFLAV--LGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLA 1619
            |.|...::...|:.:  ||.|:||:|.||...||...||:|.|:|..||..:.|.....||.:||
 Frog   679 RLKRAKMEKSMFVKIKTLGIGAFGEVCLARKTDTNALYAMKTLRKKDVLLRNQVAHVKAERDILA 743

  Fly  1620 LGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKK 1684
             ...:.::..|:.:||.:.:|:|||:|:.|||:|..:...|.|.|:.||||.||:...::.:||.
 Frog   744 -EADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGVFPEDLARFYIAELTCAVESVHKM 807

  Fly  1685 GIIYRDLKLDNVLLDYEGHVRIADFGMCK-----------------LQIYLDKT----------- 1721
            ..|:||:|.||:|:|.:||:::.|||:|.                 .|..:|.:
 Frog   808 DFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHLRQDSMDFSNEWGDPANCRC 872

  Fly  1722 -------------------ADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSG 1767
                               |.|..|||:|:|||::....|.|..||||.||:|||||:||.||..
 Frog   873 GDRLKPLEWRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILYEMLVGQPPFLA 937

  Fly  1768 CDEDE-----LFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAGDIADHIFFRPI 1827
            ....|     :.|.....|| ....:|.||:.::..|. :....|:|.  :...:|..|.||:.|
 Frog   938 QSPVETQMKVIKWQTTLHIP-AQAKLSPEASDLIVKLC-RGPEDRLGK--NGVDEIKVHPFFKNI 998

  Fly  1828 DWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTPIDKEILASMDQKQ------------ 1880
            |:. .:.||...|:.|.:.||.||..||           |:|.|.|.:.:.|.
 Frog   999 DFS-SDLRQQPAPYTPTITHPTDTSNFD-----------PVDPEKLWNDEDKDGNKNDTLNGWYK 1051

  Fly  1881 --------FHGFTY 1886
                    |:.||:
 Frog  1052 NGKHPEHAFYEFTF 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	Herpes_BLLF1	<802..1131	CDD:282904	56/331 (17%)
		STKc_nPKC_theta_like	1570..1889	CDD:270744	121/391 (31%)
lats1	XP_017949762.1	UBA_LATS1	102..142	CDD:270580	7/58 (12%)
		MobB_LATS1	614..689	CDD:439273	16/126 (13%)
		STKc_LATS1	688..1069	CDD:270775	122/395 (31%)