DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and pkn3

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	NP_001120197.1	Gene:	pkn3 / 100145241	XenbaseID:	XB-GENE-6085008	Length:	934	Species:	Xenopus tropicalis

Alignment Length:	375	Identity:	161/375 - (42%)
Similarity:	230/375 - (61%)	Gaps:	8/375 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly  1521 EGGTAPS---SPKKMLETSYTYSQFQKSG-RFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVL 1581
            ||.|.||   ||.:.:..|......:..| :..|..|.:.|.....||||.|::|||:|.|||||
Frog   555 EGATPPSPAESPGRAVGKSMKRIHGEDGGTQSNAEPTKVHRRTTLQVDDFTFISVLGRGHFGKVL 619

  Fly  1582 LAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLAL--GTKHPYLCHLFCTFQTESHLFFVM 1644
            |.:.::|...:|||.|||..::..|:::|...|:::...  .:.||:|.:||..|||:.|..|||
Frog   620 LGQFKETGKNFAIKALKKRDIVSRDELESLQCEKRIFEAVNSSGHPFLVNLFGCFQTQGHACFVM 684

  Fly  1645 EYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADF 1709
            ||:.|||||.|| .|..|||..||||.|.::.||:|||:|.||||||||||:|:|..|.|:||||
Frog   685 EYMPGGDLMMHI-HSNVFSEPTARFYSACVVLGLQFLHEKMIIYRDLKLDNLLMDASGFVKIADF 748

  Fly  1710 GMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELF 1774
            |:||..:.......:|||||:::|||::....|...||||..|||::|||:|:.||.|.||:|:|
Frog   749 GLCKEGMGFGDRTSTFCGTPEFLAPEVLTDTSYTYAVDWWGLGVLIFEMLVGECPFPGDDEEEVF 813

  Fly  1775 WSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEP 1839
            .||.||...:|.::|.:|..|::.||.|...:|:|:....|.:|...:||:.|||..|..:|::|
Frog   814 DSIVNEEVRYPRFLSNDAINIIRKLLRKSPERRLGAGVGDAEEIKPQLFFQEIDWDALYAQQVKP 878

  Fly  1840 PFKPQVKHPLDTQYFDRVFTRERVRLTPI-DKEILASMDQKQFHGFTYTN 1888
            |..|.:..|.|.:.||..||.::..|:|. |...|:|.||..|..|.:.:
Frog   879 PVVPILSDPFDIRNFDEEFTGQKAILSPSDDPRPLSSADQLLFQDFDFVS 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	121/259 (47%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	144/322 (45%)
pkn3	NP_001120197.1	HR1_PKN_1	17..82	CDD:212012
		HR1_PKN3_2	103..176	CDD:212022
		HR1_PKN3_3	186..259	CDD:212027
		C2	362..445	CDD:301316
		STKc_PKN	604..929	CDD:270741	146/326 (45%)
		S_TKc	604..849	CDD:214567	118/245 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940