DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkcdelta and prkce

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	XP_012818146.1	Gene:	prkce / 100135720	XenbaseID:	XB-GENE-981655	Length:	753	Species:	Xenopus tropicalis

Alignment Length:	390	Identity:	188/390 - (48%)
Similarity:	256/390 - (65%)	Gaps:	27/390 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly  1524 TAPSSP------------------------KKMLETSYTYSQFQKSGRFTAPATV-IPRFKNYSV 1563
            :||:||                        .|...|:.|.:|...:|.......| :...|...:
Frog   357 SAPTSPCDQEIKDLENNIRKALSFDNRGEEHKSTATAATENQLSGTGENGENGEVKLHEHKRTGL 421

  Fly  1564 DDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLC 1628
            :||:|:.||||||||||:||||:.....||:|.|||||:|:|||||.|:.|:::|||..:||||.
Frog   422 EDFNFIKVLGKGSFGKVMLAELKGRDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARRHPYLT 486

  Fly  1629 HLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKL 1693
            .|:|.|||:..|||||||:|||||||.||.|.:|.|.|:|||.||:.|.|.|||:.|:|||||||
Frog   487 QLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKL 551

  Fly  1694 DNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEM 1758
            ||:|||.|||.::|||||||..|....|..:|||||||:||||::..:|..:||||:.|||:|||
Frog   552 DNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM 616

  Fly  1759 LIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAGD--IADH 1821
            :.||.||...:||:||.||.::...:||::|.||..|||..:.|:..||:|...:...:  |..|
Frog   617 MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPNKRLGCVAAQGLEEAIKQH 681

  Fly  1822 IFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTPIDKEILASMDQKQFHGFTY 1886
            .||:.|||.|||:|:::|||||::|...|...||:.||||...||.:|:.|:..::|::|.||:|
Frog   682 PFFKEIDWVLLEQRKVKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSY 746

Fly 1887 1886
Frog 747 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	145/259 (56%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	174/319 (55%)
prkce	XP_012818146.1	C2_PKC_epsilon	3..135	CDD:175981
		C1_1	170..220	CDD:365894
		C1_1	243..293	CDD:365894
		STKc_nPKC_epsilon	428..748	CDD:270743	174/319 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040