DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkcdelta and prkcq

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	XP_012813823.2	Gene:	prkcq / 100038268	XenbaseID:	XB-GENE-487643	Length:	699	Species:	Xenopus tropicalis

Alignment Length:	405	Identity:	203/405 - (50%)
Similarity:	263/405 - (64%)	Gaps:	40/405 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1497 GGGASTSSSPSIIRMSTCSNDSGFEG-------GTAPSSPKKMLETS-----YTYSQFQKSGRFT 1549
            |...:|...|.::.:...|....:|.       ..:|..|:..:|.|     .|:|
Frog   316 GPTTNTQDQPIVLSIKKESQGISWESPIESIKVQESPPEPELKIEQSSCQIKVTFS--------- 371

  Fly  1550 APATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIE 1614
                           ||....:|||||||||.||||:.|..::|||.|||||||.||||:.|::|
Frog   372 ---------------DFVLHKMLGKGSFGKVFLAELKRTNQFFAIKVLKKDVVLMDDDVECTMVE 421

  Fly  1615 RKVLALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLK 1679
            ::||:|..:||:|.||:|||||:.|||||||||||||||||||...:|...||.||.|||:.||:
Frog   422 KRVLSLAWEHPFLTHLYCTFQTKEHLFFVMEYLNGGDLMFHIQSCHKFDLPRATFYAAEIVCGLQ 486

  Fly  1680 FLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYNQ 1744
            |||.||::||||||||:|||.|||::||||||||..:..|....:|||||||:||||:.|:|||.
Frog   487 FLHSKGVVYRDLKLDNILLDMEGHIKIADFGMCKESMLGDAKTSTFCGTPDYIAPEILLGQKYNY 551

  Fly  1745 NVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIG 1809
            :||||||||||||||||||||.|.||:|||.||..:.|.:|.::|.||..||..|..::..:|:|
Frog   552 SVDWWSFGVLLYEMLIGQSPFHGIDEEELFQSIRMDNPMYPRFLSMEAKDILIMLFVREPERRLG 616

  Fly  1810 SQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLTPIDKEILA 1874
            .:    |||..|.||:.||||.||.|:|||||||:||...|...||:.|..|:.||:..::.::.
Frog   617 VK----GDIRQHCFFQHIDWGRLENREIEPPFKPKVKSADDWSNFDKEFLNEKPRLSSSERTLIN 677

  Fly  1875 SMDQKQFHGFTYTNP 1889
            ||||..|:.|::.||
Frog   678 SMDQNMFNNFSFVNP 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	158/257 (61%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	188/318 (59%)
prkcq	XP_012813823.2	C1_nPKC_theta-like_rpt1	150..210	CDD:410384
		C1_nPKC_theta-like_rpt2	229..278	CDD:410387
		STKc_nPKC_theta	367..697	CDD:270770	194/354 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I1125
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	609	1.000	Inparanoid score	I910
OMA	1	1.010	-	-		QHG45425
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	1	1.000	-	-		otm47618
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110