DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkcdelta and pkn1b

DIOPT Version :9

Sequence 1:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster
Sequence 2:	NP_001082929.1	Gene:	pkn1b / 100007897	ZFINID:	ZDB-GENE-070424-87	Length:	909	Species:	Danio rerio

Alignment Length:	918	Identity:	258/918 - (28%)
Similarity:	398/918 - (43%)	Gaps:	182/918 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1046 GQPAKSPEQQQATAAAVETKINKTTDKEQQQQQQQQQQQQAQQQQQQLIDTAATLVPQTETK--- 1107
            |.|.:|...|. ...|:|.::|.....:|..:...........:.::|:.:|..::..::||
Zfish    96 GTPGRSSANQD-RIKALERQLNIELKVKQGAENMIPIYANGVTKDKKLLQSAQQMLQDSKTKIDI 159

  Fly  1108 -----TKLTEAAEPTGKSKVQSPNTT-KPKSAG------------KTNVGKKKAATPAAAAAAAA 1154
                 .|..:|.|       ||.:|. ||...|            :......:.|..........
Zfish   160 IRMQIRKAMQATE-------QSDDTQGKPDLCGVELRIEELWHHYRVEHAMAEGAKNMLRLLGTG 217

  Fly  1155 AAAPAAATATEAVTALSESNVTPINADQFITLAPTKAAKTSPNKQQALQLQQQH-------EEQQ 1212
            .|....|.| ||.:.|||       |.|.:.|.....      :|:.:.|.:.|       ||..
Zfish   218 KAQDKKAIA-EAQSRLSE-------ASQRLDLLRVSL------EQRLVNLPEDHPKACLIKEELV 268

  Fly  1213 RQQQQQ-ATNASSPAATGDATT----TPTTITIGVAAVN-VAAVAVVASAAAAAAT--------D 1263
            |..... :::.|:|......:|    :|.|.|:.|..:. |..:.:|...:.|:..        |
Zfish   269 RASSSAFSSSHSAPYVHNQYSTLSRPSPLTGTLQVRLLGCVDLLEMVPGRSRASPVVLPHFSPGD 333

  Fly  1264 AAADATTSLSSNNSC----GEGVGNNLSKFATVSNLAQCL------RDVDAEL-DDYIPSSAENS 1317
            ..|...| |||.:|.    ........|:.:.|..|..|:      :.|..:. |.......|.|
Zfish   334 GRAFKLT-LSSRSSSFSLKTPSKSEESSEVSAVLKLENCVVGQTCWKSVGEQTWDQTFTLELERS 397

  Fly  1318 QEDDDDDDDGSGSSSDDYSSVDGCA----NLSASMKKKLRKEKKKQKAKAAAAAEAKRFDPHKKI 1378
            :|.:      ......||.|:  ||    .|...:..:..:.:.:.:.:....||...|:|
Zfish   398 REME------IALYWKDYRSL--CALKYLKLEDFLDNQRHRVQLELEPQGLLLAEVMFFNP---- 450

  Fly  1379 KIDTTNKCYVKEEAPRYPLVATPRPLWKREKIVYSDENTDDESGSEEGSGGSLDEDSDDESGGEE 1443
                     |.|..||.          :|::.|:|.:.
Zfish   451 ---------VIERGPRL----------QRQRKVFSKQQ--------------------------- 469

  Fly  1444 CSSTSSSASSEDLDAVAMVTKAGSSNATTV-------LDSSNSSGSNAGTLSVPSAGSGSGGGAS 1501
             ......|...::|....|...  .||.|:       ...::.|.|......:...|
Zfish   470 -GKAFLRAKQMNVDMATWVRLL--KNAITIPTHNYTQHSHTHHSSSEISIQKIQLDG-------- 523

  Fly  1502 TSSSPSIIRMSTCSNDSGFEGGTA-------PSSPKKMLETSYTYSQFQKSGRFTAPATVIPRFK 1559
             .|.||:.|.:|.::.:...|..|       |:.|::::.:....||.:.|.            .
Zfish   524 -ESPPSVTRRNTHTSATVDFGRAAEPVSPPGPAPPERVVRSISHLSQRRSSK------------S 575

  Fly  1560 NYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLAL--GT 1622
            ...:.||..:||||:|.||||||:|.|.:...||||.|||..::..|:|:|.:.|:::...  ..
Zfish   576 ALCLQDFRMIAVLGRGHFGKVLLSEYRRSGNLYAIKALKKGDIVARDEVESLMCEKRIFETVNSA 640

  Fly  1623 KHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGII 1687
            :||:|.:||..|||..|:.|||||..|||||.|| .:..|||.|:.||.|.::.||:|||...|:
Zfish   641 QHPFLVNLFACFQTPEHVCFVMEYTAGGDLMMHI-HADVFSETRSVFYSACVVLGLQFLHDNKIV 704

  Fly  1688 YRDLKLDNVLLDYEGHVRIADFGMCKLQI-YLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSF 1751
            ||||||||:|||.||:|:|||||:||..: :.|:|: :|||||:::|||::....|.:.||||..
Zfish   705 YRDLKLDNLLLDTEGYVKIADFGLCKEGMGHGDRTS-TFCGTPEFLAPEVLTDTSYTRAVDWWGL 768

  Fly  1752 GVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAG 1816
            |||:|||::|:|||.|.||:|:|.||.|:...:|.::|.||.||::.||.::..:|:||....|.
Zfish   769 GVLIYEMMVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAIGIMRRLLRRNPERRLGSGEKDAE 833

  Fly  1817 DIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFDRVFTRERVRLT-PIDKEILASMDQKQ 1880
            ||....|||.:||..|.:|::.|||.|.|.:..|...||..||.|...|| |.::..|:..||..
Zfish   834 DIKKQPFFRNMDWDALLQRKVPPPFVPAVANSEDVSNFDAEFTNEAPTLTPPRERRSLSRKDQDY 898

  Fly  1881 FHGFTYTN 1888
            |..|.|.:
Zfish   899 FKDFDYVS 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	127/260 (49%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	153/323 (47%)
pkn1b	NP_001082929.1	HR1_PKN_1	15..80	CDD:212012
		HR1_PKN1_2	99..176	CDD:212020	15/84 (18%)
		HR1_PKN1_3	180..253	CDD:212026	16/86 (19%)
		C2	364..447	CDD:301316	16/90 (18%)
		STKc_PKN	582..907	CDD:270741	154/327 (47%)
		S_TKc	582..841	CDD:214567	127/260 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583336
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840