DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir11a and grin2bb

DIOPT Version :9

Sequence 1:	NP_572795.2	Gene:	Ir11a / 32189	FlyBaseID:	FBgn0030385	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_001121809.1	Gene:	grin2bb / 559976	ZFINID:	ZDB-GENE-061207-27	Length:	1770	Species:	Danio rerio

Alignment Length:	411	Identity:	78/411 - (18%)
Similarity:	152/411 - (36%)	Gaps:	96/411 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 DLLQLLAKALKFRIQLYM---PQEPSQIFGEGNVSGCFRQLADGTVSIAIGGLSGSDKRRSLFSK 340
            |:|:.:||::||...||:   .:...:|.|..|  |...::......:|:|.|:.:::|..:...
Zfish   542 DILKKIAKSVKFTYDLYLVTNGKHGKKINGTWN--GMVGEVVLKNAHMAVGSLTINEERSEVIDF 604

  Fly   341 STVYHQSNFVMVVRRDRYLGRLGP--LILPFRGKLWGVIIVILLLAVLSTCWL---RSRLGLSHP 400
            |..:.::...::|.|..  |.:.|  .:.||...:|.::.|:||:......::   .|.:|.:..
Zfish   605 SVPFIETGISVMVSRSN--GTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRC 667

  Fly   401 IED-----------------LLTVIVGNPIPDHRLPGKGFLRYLLAS-WMLLTLVLRCAYQARLF 447
            :.|                 |..::..|.:|...  .||....::.| |....::...:|.|.|
Zfish   668 LADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQN--PKGTTSKIMVSVWAFFAVIFLASYTANL- 729

  Fly   448 DVLRLSRHRPLPKDLSGLIKDNYTMVANGYHDFYPLELTCRQPLDFSA--RFERVQRAAPDERLT 510
                          .:.:|::.|.....|..|     ...:.|.|||.  ||..|...:.:..:.
Zfish   730 --------------AAFMIQEEYVDQVTGLSD-----KKFQHPNDFSPPFRFGTVPNGSTERNIR 775

  Fly   511 T--IALISNLAYWNHKHPN--ISRLTFVRQPIYMYHLVI--YFPRR-------------FFL--- 553
            .  ..:.|.:..::.|:.|  :..|...:...::|...:  |...|             .|.
Zfish   776 NNYKEMHSYMTSFHQKNVNEALHSLKSGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTG 840

  Fly   554 -----------RPAIDRKIKQLLSAGVMAHIERRYMQ---YENKRKVASNDPVLLRRITKSIMNG 604
                       :.|:|..|.||...|.|..:|..::.   :..|.:|.|:      ::....|.|
Zfish   841 YGIAIQKDSGWKRAVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSS------QLDVDNMAG 899

  Fly   605 AYRIHGLVIVLATGMFILELL 625
            .:.:.|..:.|:...||.|.|
Zfish   900 VFYMLGAAMALSLITFIAEHL 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir11a	NP_572795.2	Periplasmic_Binding_Protein_Type_2	306..>356	CDD:304360	8/49 (16%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..470	CDD:107373
		ANF_receptor	138..442	CDD:279440
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	67/365 (18%)
		Lig_chan	636..908	CDD:278489	50/299 (17%)
		NMDAR2_C	919..1770	CDD:287527	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910