DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir11a and gria4b

DIOPT Version :9

Sequence 1:	NP_572795.2	Gene:	Ir11a / 32189	FlyBaseID:	FBgn0030385	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_997917.2	Gene:	gria4b / 336069	ZFINID:	ZDB-GENE-030131-8013	Length:	904	Species:	Danio rerio

Alignment Length:	222	Identity:	44/222 - (19%)
Similarity:	80/222 - (36%)	Gaps:	49/222 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 EDLAGIDWDLLQLLAKALKFRIQL-------YMPQEPSQIFGEGNVSGCFRQLADGTVSIAIGGL 328
            |...|...||...:||.:.|:.::       |..::|......|.|.    :|..|...||:..|
Zfish   441 EQYEGYCVDLASEIAKHIGFKYKISIVPDGKYGARDPETKIWNGMVG----ELVYGKAEIAVAPL 501

  Fly   329 SGSDKRRSLFSKSTVYHQSNFVMVVRRDRYLGRLGPLIL----PFRGKLW--------GVIIVIL 381
            :.:..|..:...|..:......:::::.:   :..|.:.    |...::|        ||.:|:.
Zfish   502 TITLVREEVIDFSKPFMSLGISIMIKKPQ---KSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 563

  Fly   382 LLAVLS------------TCWLRS-----RLGLSHPIEDLLTVIV--GNPIPDHRLPGKGFLRYL 427
            |::..|            |..|.|     ..|:.:.:...|...:  |..|....|.|    |.:
Zfish   564 LVSRFSPYEWHTEEPEEGTDGLPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSG----RIV 624

  Fly   428 LASWMLLTLVLRCAYQARLFDVLRLSR 454
            ...|...||::..:|.|.|...|.:.|
Zfish   625 GGVWWFFTLIIISSYTANLAAFLTVER 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir11a	NP_572795.2	Periplasmic_Binding_Protein_Type_2	306..>356	CDD:304360	9/49 (18%)
gria4b	NP_997917.2	Periplasmic_Binding_Protein_Type_1	28..398	CDD:324556
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	44/222 (20%)
		Lig_chan	546..827	CDD:306551	24/110 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910