DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir11a and GRID1

DIOPT Version :9

Sequence 1:	NP_572795.2	Gene:	Ir11a / 32189	FlyBaseID:	FBgn0030385	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	433	Identity:	90/433 - (20%)
Similarity:	176/433 - (40%)	Gaps:	76/433 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 ASNVSIPAEDLAGIDWDLLQLLAKALKFRIQLYMPQEPSQIFGE--GNVS--GCFRQLADGTVSI 323
            |.|:....:...|...|:|..|||||.|:.::|  |.|...:|.  .|.|  |...:|......:
Human   453 AENILGQPKRYKGFSIDVLDALAKALGFKYEIY--QAPDGRYGHQLHNTSWNGMIGELISKRADL 515

  Fly   324 AIGGLSGSDKRRSLFSKSTVYHQSNFVMVVRRDRYLGRLGPLILPFRGKLW----------GVII 378
            ||..::.:.:|.|:...|..|...:..:::::......:..|..||...:|          ||:|
Human   516 AISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLI 580

  Fly   379 VIL--LLAVLSTCWLRSRLGLSHPIEDLLTVIVGNPIPDHRLPGKG-----FLRYLLASWMLLTL 436
            .:|  :.||.:....:.|...|..:...:.::.|..:   :..|:.     .:|.::.||.|.||
Human   581 FVLNRIQAVRAQSAAQPRPSASATLHSAIWIVYGAFV---QQGGESSVNSMAMRIVMGSWWLFTL 642

  Fly   437 VLRCAYQARLFDVLRLSR-HRPLP--KDLSGLIKDNY-TMVANGYHDFYPLELTCRQPLDFSARF 497
            ::..:|.|.|...|.:|| ..|:.  :|||..::.:| |:..:..::::..:.|  .||:..:.|
Human   643 IVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGT--NPLEQDSTF 705

  Fly   498 ERVQR------------AAPDERLTTIALISNLAY-WNHKHPNISRL-------TFVRQPIYMYH 542
            ..:.|            ::|.|.:.. |...|.|: |:......:.|       |.:...|....
Human   706 AELWRTISKNGGADNCVSSPSEGIRK-AKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKG 769

  Fly   543 LVIYFPRRFFLRPAIDRKIKQLLSAGVMAHIERRYMQYENKRKVASNDPVLLRRITKSIMNG-AY 606
            ..|........|....::|.:|...|.:..:::::..:..:..:.|:        ..:..:| :.
Human   770 YGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSH--------ASAQADGKSL 826

  Fly   607 RIH---GLVIVLATGMFILELLAGRSNGRLRRWMEW----VHQ 642
            ::|   |:..:||.|:.:..|:|.     |..|  |    .||
Human   827 KLHSFAGVFCILAIGLLLACLVAA-----LELW--WNSNRCHQ 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir11a	NP_572795.2	Periplasmic_Binding_Protein_Type_2	306..>356	CDD:304360	10/53 (19%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436
		PBP1_iGluR_delta_1	25..423	CDD:107387
		ANF_receptor	41..400	CDD:279440
		PBP2_iGluR_delta_1	436..806	CDD:270448	76/360 (21%)
		Lig_chan	564..841	CDD:278489	54/290 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910