DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2577 and VRK2

DIOPT Version :9

Sequence 1:	NP_572794.1	Gene:	CG2577 / 32188	FlyBaseID:	FBgn0030384	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_001123952.1	Gene:	VRK2 / 7444	HGNCID:	12719	Length:	508	Species:	Homo sapiens

Alignment Length:	317	Identity:	94/317 - (29%)
Similarity:	140/317 - (44%)	Gaps:	59/317 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GNYKVV-RKIGCGSFGDIYLGIYIHSGERVA---IKVESSK-----------------------V 52
            ||..|: :|||.|.||.|||....:..|:.|   :|||..:                       :
Human    26 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWI 90

  Fly    53 RHPQLNYERRIYRALRPAHGLPRIRYFH-------KEEHYQAMVMDLLGPSLERLFQFCERAFTI 110
            ...||:|           .|:|   .|:       |...|:.|||:.||..|::: ......|..
Human    91 ERKQLDY-----------LGIP---LFYGSGLTEFKGRSYRFMVMERLGIDLQKI-SGQNGTFKK 140

  Fly   111 KTVLLLAEQMLRRVEYVHNRGFLHRDIKPDNFLMGLGTMSKQVYLIDFGLSKKYLDITTGVHIPY 175
            .|||.|..:||..:||:|...::|.|||..|.|:|... ..||||.|:|||.:|  ...|.|..|
Human   141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN-PDQVYLADYGLSYRY--CPNGNHKQY 202

  Fly   176 RE--ERSLTGTARYASIGAHAGVESARRDDMVAVGYVLMYFNRGSLPW-QDLK--ASTKQQKYER 235
            :|  .:...||..:.|:.||.||..:||.|:..:||.::.:..|.||| |:||  .:.:..|...
Human   203 QENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNL 267

  Fly   236 IHEKKISVSIEVLCEGFPCEFTMYLNYCRGMGFYDKPNYDFICRMFRMLRNGLNLRP 292
            :.|...||..........||...:|.....:.:.:||||..:.::..  .:|:.|.|
Human   268 LDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILN--PHGIPLGP 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2577	NP_572794.1	STKc_CK1	16..281	CDD:270918	90/303 (30%)
CG2577	NP_572794.1	SPS1	16..>242	CDD:223589	81/264 (31%)
VRK2	NP_001123952.1	STKc_VRK2	16..314	CDD:271025	91/305 (30%)
		SPS1	29..421	CDD:223589	92/314 (29%)
		Interaction with MAP3K7. /evidence=ECO:0000269\|PubMed:17709393	397..508
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810