DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2577 and VRK3

DIOPT Version :9

Sequence 1:	NP_572794.1	Gene:	CG2577 / 32188	FlyBaseID:	FBgn0030384	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_057524.3	Gene:	VRK3 / 51231	HGNCID:	18996	Length:	474	Species:	Homo sapiens

Alignment Length:	281	Identity:	67/281 - (23%)
Similarity:	125/281 - (44%)	Gaps:	48/281 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 QLNYERRIYRALRPAHGLPRIRYF--HKEEHYQAMVMDLLGPSLERLFQFC-ERAFTIKTVLLLA 117
            |:|..:::|..  |...:|....|  |::: |:.:|:..||.||:...... :...:.::||.:|
Human   226 QVNKWKKLYST--PLLAIPTCMGFGVHQDK-YRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVA 287

  Fly   118 EQMLRRVEYVHNRGFLHRDIKPDNFLMGLGTMSKQVYLIDFGLSKKYLDITTGVHIPYRE-ERS- 180
            .::|..:|::|...::|.::..:|..:.....| ||.|..:|.:.:|  ..:|.|:.|.| .||
Human   288 CRLLDALEFLHENEYVHGNVTAENIFVDPEDQS-QVTLAGYGFAFRY--CPSGKHVAYVEGSRSP 349

  Fly   181 LTGTARYASIGAHAGVESARRDDMVAVGYVLMYFNRGSLPWQDLKASTK---QQKYERIHEKKIS 242
            ..|...:.|:..|.|...:||.|:.::||.::.:..|.|||.:...:|:   :||.:.:.:....
Human   350 HEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPF 414

  Fly   243 VSIEVLCEGFPC--------EFTMYLNYCRGMGFYDKPNYDFICRMFRMLRNGLNLRPGLIYDWD 299
            |.        ||        ....||.....:.:.:||.|       .||||.|          :
Human   415 VG--------PCGHWIRPSETLQKYLKVVMALTYEEKPPY-------AMLRNNL----------E 454

  Fly   300 MLMMKFHNTQKNPGIGMRVFP 320
            .|:.....:..:| ||:.:.|
Human   455 ALLQDLRVSPYDP-IGLPMVP 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2577	NP_572794.1	STKc_CK1	16..281	CDD:270918	57/240 (24%)
CG2577	NP_572794.1	SPS1	16..>242	CDD:223589	49/193 (25%)
VRK3	NP_057524.3	zinc_ribbon_2	4..26	CDD:289981
		DZR	5..>31	CDD:289539
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..152
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:14645249	49..64
		DUF4551	<82..>150	CDD:291746
		PKc_like	155..457	CDD:304357	62/261 (24%)
		SPS1	211..>467	CDD:223589	63/271 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810