DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2577 and vrk1

DIOPT Version :9

Sequence 1:	NP_572794.1	Gene:	CG2577 / 32188	FlyBaseID:	FBgn0030384	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_998550.1	Gene:	vrk1 / 406694	ZFINID:	ZDB-GENE-040426-2709	Length:	425	Species:	Danio rerio

Alignment Length:	354	Identity:	105/354 - (29%)
Similarity:	168/354 - (47%)	Gaps:	59/354 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 YKVVRKIGCGSFGDIYLGIYIHSGERVA-----IKVESSKVRHPQLNYERRIY-RALRP------ 69
            :|:...:|.|.||.:||.....||...|     ||||.|.  :..|..|.:.| ||.:|
Zfish    38 WKLGSAVGQGGFGLLYLANEDSSGPVTADAPYVIKVEPSD--NGPLFSELKFYMRAAKPDLIGAW 100

  Fly    70 -------AHGLPRIRY----FHKE--EHYQAMVMDLLGPSLERLFQFCERAFTIKTVLLLAEQML 121
                   ..|:|  :|    ||::  :.|:.||||..|..|::||:...:.|:.|.||.|..::|
Zfish   101 MKSKKMEYLGVP--KYWGSGFHEKNGKRYRFMVMDRFGTDLQKLFEGNGKKFSRKLVLQLGLRLL 163

  Fly   122 RRVEYVHNRGFLHRDIKPDNFLMGLGTMSKQVYLIDFGLSKKYLDITTGVHIPYREE--RSLTGT 184
            ..:||:|:..::|.|||..|.|:.. |...||:|:|:||:.:|  ...||...|:|:  |...||
Zfish   164 DILEYIHDHEYVHADIKASNLLLSY-TNPNQVFLVDYGLAYRY--APEGVPKEYKEDPKRCHDGT 225

  Fly   185 ARYASIGAHAGVESARRDDMVAVGYVLMYFNRGSLPWQDLKASTKQQKYERIHEKKISVSIEVLC 249
            ..:.||.||.||..:||.|:..:||.::.:....|||:|   ..:...|.|..:.:...:|:...
Zfish   226 IEFTSIDAHKGVSPSRRADLEIMGYCMIQWLCSRLPWED---KLQDPLYVRDSKLRCRDNIDEFL 287

  Fly   250 E------GFPCEFTMYLNYCRGMGFYDKPNYDFICRMFRMLRNGLNLRPGLIYDWDMLMMKF--- 305
            :      ..|.|...::...:.:|:.|:|:||   ::..:|:.||.    .|...|...:.|
Zfish   288 KSCFASGNIPAEMGKFMQEVKVLGYTDRPDYD---KLRGILQQGLK----SIGSTDDKKLDFGVA 345

  Fly   306 HNTQKNPGIGMRVFPPKQK--EDDGISGE 332
            .|:...|.    |..||:|  |:.|.|.:
Zfish   346 TNSTSLPS----VKTPKRKKAEEKGQSAD 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2577	NP_572794.1	STKc_CK1	16..281	CDD:270918	90/296 (30%)
CG2577	NP_572794.1	SPS1	16..>242	CDD:223589	82/251 (33%)
vrk1	NP_998550.1	PKc_like	27..327	CDD:304357	91/301 (30%)
		SPS1	37..>265	CDD:223589	80/236 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..425		9/32 (28%)
		GAGA_bind	<373..>424	CDD:283799
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810