DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ten-a and Tnxb

DIOPT Version :9

Sequence 1:NP_001162732.2 Gene:Ten-a / 32183 FlyBaseID:FBgn0267001 Length:3387 Species:Drosophila melanogaster
Sequence 2:XP_006525248.1 Gene:Tnxb / 81877 MGIID:1932137 Length:4361 Species:Mus musculus


Alignment Length:2784 Identity:559/2784 - (20%)
Similarity:826/2784 - (29%) Gaps:1014/2784 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   933 TCPNDCSGRGSCYLGKCDCIDGYQGVDCSKSVCPVLCSAHGHYGGGVCHCEEGWKGAECDIPVGE 997
            :||.||.|||:|..|:|.|..||.|.||....||..|...|....|.|.|..|:.|.:|    |.
Mouse   452 SCPGDCRGRGNCESGRCVCWPGYTGRDCGTRACPGDCRGRGRCVDGRCVCNPGFTGEDC----GS 512

  Fly   998 CEVP-NCSSHGRCIEGECHCERGWKGPYCDQHDCLDPLCSGHGTCVAGQCYCKAGWQGEDCGTID 1061
            ...| :|..||.|..|.|.|..|:.|..|....|... |.|.|.|:.|.|.|..|:.|||||   
Mouse   513 RRCPGDCRGHGHCENGVCVCAVGYSGDDCSTRSCPSD-CRGRGQCLNGLCECDEGYSGEDCG--- 573

  Fly  1062 QQVYQCLPGCSEHGTYDLETGQCVCERHWTGPDCSQAVCSLDCGRNGVCESGKCRCNSGWTGNLC 1126
              :.:|...||:||.  .:.|.|:|...:.|.|||...|..||.|.|.||.|:|.||.|:||..|
Mouse   574 --IRRCPRDCSQHGV--CQDGLCMCHAGYAGEDCSIRTCPADCRRRGRCEDGRCVCNPGYTGPAC 634

  Fly  1127 DQLPCDSRCSEHGQCKNGTCVCSQGWNGRHC-----TLPGCENGCS-----RHGQCTLENGEYRC 1181
            ....|.:.|...|:|..|.|:|..|::|..|     ....|..||.     |.|||.        
Mouse   635 ATRTCPADCRGRGRCVQGVCMCYVGYSGEDCGQEEPPASACPGGCGPRELCRAGQCV-------- 691

  Fly  1182 DCIEGWAGRDCSIALELNCKDNIDNDGDGMTDCSDSECCSHPA-----CSEHIMCLSSN------ 1235
             |:||:.|.||:|.   .|..:..:.|    :|....|.....     |.|.|..:.:.      
Mouse   692 -CVEGFRGPDCAIQ---TCPGDCRSRG----ECIQGRCVCQEGYAGDDCGEEIPAIQNMRMHLLE 748

  Fly  1236 ---------------DPVEVLLRKQPPSVTASFYQRVKFLIEENSVQSYAHMDEYS---ENLFWS 1282
                           |..|:........|:..|..||.........:..|...:|.   ..|..:
Mouse   749 ETTVRTEWTRAPGPVDAYEIQFIPMTEGVSPPFTARVPSSASAYDQRGLAPGQDYQVTVRALRGT 813

  Fly  1283 SFTPCRVSVMRGQVITPQGLGIVGI------------RVSVDRDSRFGFTLTRQGGWFDVLVNGG 1335
            |:.|.....:...:..||.|.:|.:            :..|||     |.::        .|:.|
Mouse   814 SWGPPASKTITTMIDGPQDLRVVAVTPTTLDLSWLRPQAEVDR-----FVVS--------YVSAG 865

  Fly  1336 GAVTLQFQRSPFRPLTRTVFVPWNRIVVLPPV-QMQLSDDDETTSRNIKVAPLNPALTFL----- 1394
            .      ||.              |:.|.|.. :.||:|             |.|.:.::     
Mouse   866 N------QRV--------------RLEVPPEADRTQLTD-------------LMPGVEYVVTVTA 897

  Fly  1395 ---NSIHYHTADEANDA-------------------------SKVC----MDHDHEKLRPQLIS- 1426
               :::.|..:..||.|                         |:..    .|.....|||:|.. 
Mouse   898 ERGHAVSYPASIRANTAPGHYSYPEVRPPAPPPNPRPRPRWPSRPLPSPETDEKEWHLRPRLPQP 962

  Fly  1427 ---TWMPNGVGAMPGKRVIFAET-QIVQESIQIPGSDLHLTYQSSQASGYL-SIVRMRLTGETIP 1486
               .|     |.:..:...|..| |.::..::..|..|......:..:.|: ..::...|.....
Mouse   963 PRRPW-----GNLTTELSRFRGTVQDLEHHLRTHGYPLRANQTYASVARYIHEFLKRHQTAGAPA 1022

  Fly  1487 PTLTHVH------------------VGVEIEGALHVKTYE----------ADPSLVHT------- 1516
            ....|.|                  ||...:||..|.|..          ||.||:.:       
Mouse  1023 SQPRHPHPTTSPTQNTRKRDSEQGAVGPASDGAHPVTTARHPKPEVLGSAADGSLIVSLDGLRGQ 1087

  Fly  1517 -----FAW-----------------NKRNV----------YRQKVYGVTVARISVGYQHST---- 1545
                 ..|                 ::|.|          |..:|:||...:.|..|...|    
Mouse  1088 FERVVLRWRPLLPAKGPSGELTVDGSERTVRLPNLRPGTTYHVEVHGVRAGQTSKSYAFITTTTT 1152

  Fly  1546 ---------------------------CQSPVWIAQTAKLQGYDVDISDIGG-----WGL--DIH 1576
                                       .|:|:.|.:...|....|...|..|     |..  |..
Mouse  1153 TTTGSLPSGLLEATDEPPPSGPSTTQGAQAPILILEHHPLGELKVLGRDKAGRLSVAWTAQPDSF 1217

  Fly  1577 HHYNFHEGILQKGDGSTLHMKEYPRTVKVVMGTGLQRPLTCPDYCNGVAKDAKLLTPIALATGPD 1641
            .|:...   :|..:|...|.:..|..|        |:.|..|.                    |.
Mouse  1218 AHFQLR---MQVAEGPWAHEELLPGDV--------QQALVPPP--------------------PP 1251

  Fly  1642 GSLYVGDFNLVRRITPDGKVYTILQLSATQVSYQYYL----------AVSPADGHLYISDPERHQ 1696
            |:.|.   ..:..|||.||:       :..::||..:          :|.|..|.|.::      
Mouse  1252 GAPYK---LFLHGITPGGKI-------SVPITYQGIMDRAQEQPGKPSVQPRLGELTVT------ 1300

  Fly  1697 ILRLVRLEKVKDPSINSDPVVGSGQRCIPGDEGNCGDGGPALLARLSHPKG-----LAIAADRTM 1756
                         .:.||                      :||...:.|:|     |....|:  
Mouse  1301 -------------GLTSD----------------------SLLLHWTVPEGEFDSFLIQYKDK-- 1328

  Fly  1757 YIADG------------TNIRAVDP----KGVIHTLIGHHGHHNHWSPAPCSGTLMA-------- 1797
               ||            |.|..::|    |.:::.|||...|          |.|||        
Mouse  1329 ---DGPQAISVEGPQRSTPISGLEPGRKYKFILYGLIGKKRH----------GPLMAEAKILIQS 1380

  Fly  1798 --------------------NQAQLQWPT-----------------------------GLALSPL 1813
                                :...|.|..                             .:.:|||
Mouse  1381 DPDPGSPPRLGELWVTDPTPHSLHLSWTVLGGQFDSFVVQYRDKEGQPRVVPVEGPDRSVVISPL 1445

  Fly  1814 DGSLHFIDDRLVL----------RLTSDMKIRVVAGTPLHCSNGGQDGRVNKTG-ADNVLGTVLA 1867
            |.:..:   |..|          .||:|.  ...|.|....|...:.|.:..|| ..:.|.....
Mouse  1446 DPNRKY---RFTLFGIANKKRYGPLTADG--TTAAETKEESSEPPRLGELTVTGVTPDSLRLSWT 1505

  Fly  1868 MAFSPFGNLYIADSDSR----------RVNSIRVVDTAGNMRY------FAGKQEGTGSQTCDCA 1916
            :|..||.:..|...|::          ..|.:.|.....|.:|      ..|:|.          
Mouse  1506 VARGPFDSFVILYKDAQGQPQSVPIEGDENEVTVPGLESNRKYKMNLYGLRGRQR---------- 1560

  Fly  1917 IGGGSNGSATNSGVGGAGGSAYSTTVNPTRPNGG--------------TTPTTPSGGNGNGNGNG 1967
            :|..|..:.|      |........::|..|:..              .|.|||       |...
Mouse  1561 VGPVSVVAKT------APPDVVDQPLSPPEPSTEAPEPPEKPLLRELIVTDTTP-------NSLS 1612

  Fly  1968 SSATSSGGS-----VGGSNGSG-------GGANGGACICAGGIALSTGT-----------GSSSG 2009
            .|.|.|.|.     :...||.|       .|......|        :|.           |..||
Mouse  1613 LSWTVSEGQFDQFVIQYKNGDGQPKVVRVPGHEDQVTI--------SGLEPDHKYKMNLYGIHSG 1669

  Fly  2010 SNGGGTLASIVG---------SGGLMST-GPTTTTTVLLGAKTTAAGIGAATLNDDGTLSNAETL 2064
            ...|.  .|:||         |....|| .|..|...||| :.|..|....:|:...|:...:  
Mouse  1670 QRVGP--VSVVGVTAAEEEPPSPTEPSTEAPEPTEEPLLG-ELTVTGSSPDSLSLSWTVPQGD-- 1729

  Fly  2065 LSSNARFQAISAIAVAQDG---VINVADQGSLHVLALEHYLPSHDENGEFHIPFPPSSEIYVFNR 2126
                  |.:.:....:.||   |:.|.  |....:.:....|.|.               |..|.
Mouse  1730 ------FDSFTVQYKSSDGRPQVMRVG--GQEREVIVRDLDPGHK---------------YKMNL 1771

  Fly  2127 YGQH-------VATKDLTSGKTRYSFLYSKNTSFGRLS--TVTDASGNKIQFL-----RDYSNVV 2177
            ||.|       |:|...|..:..     .|.....||.  |||..:.|.:...     ..:.:.|
Mouse  1772 YGLHEGHRVGPVSTVGTTDKQPE-----EKPPLEPRLEELTVTGVTPNSVSLSWIVPEGQFDSFV 1831

  Fly  2178 SSIENTQDHKSEIQINGIGIMTKLSEKGRQEIELDYD-------SNTGLLNSRSSGGETYIYQYD 2235
            ...::......|:         .|:.:.|:...||.|       :..||...|..|..:.....|
Mouse  1832 VQYQDRDGQPREV---------PLTAEQREVTVLDLDPARIYKMNFYGLHGRRRVGPLSVSAMTD 1887

  Fly  2236 EFGRV------TGMILPS---GEIVRITSQLADSQGLTVYVHASVESLFSRERIAGEANELLVLG 2291
            .....      ...:||.   ||:. :|....||.||...|.            .||.:...|..
Mouse  1888 SLSPAPAPATEASKLLPEPRLGELT-VTDVTPDSVGLLWTVP------------EGEFDSFTVQY 1939

  Fly  2292 GVRSTFLKRGQAHADAELKANNTLVIHGDNGVVVEASAVARHPLLEAALPVEAEMLAMWSHQSVT 2356
            ..|.     ||.|                   ||..:|..|...:....|.......::..|   
Mouse  1940 KDRD-----GQPH-------------------VVSVAADLREVTIPGLEPSRKYKFLLFGVQ--- 1977

  Fly  2357 MGEGLTNSMYSVYSLVG--DVRNPQQTLN-REIWVNQSRVIGVEFDQFTNRETFYDARRTPILIV 2418
              :|...|..||.:...  |..:|..... .|:||.......:.. .:|..|..:|:     .:|
Mouse  1978 --DGKRRSQVSVEAKTATHDDTSPGAPPRLGELWVTDPTTDSLRL-SWTVPEGHFDS-----FVV 2034

  Fly  2419 AY-DQSGLPKSYYPTNGYPVNITYDRFNRVEGWAWGPAELKYSYDRHGLL-------------SE 2469
            .: |:|| |: ..|..|.....|....:         |..||.:..:|||             :|
Mouse  2035 QFKDKSG-PR-VVPVKGQERTATITALD---------AGRKYRFLLYGLLGRKRFGPLTAEGITE 2088

  Fly  2470 ITSQQD----------GIVSFVYNDWNLVSEIGLASQRKFVLQYDDAGGLRHVVLPSGTRHSFSM 2524
            .|:..|          .:.....|..:|...:.......||:||.|..|...||...|:...   
Mouse  2089 PTNAADHTKSRLGEELRVTGVTQNSVDLSWTVSEGQFDSFVVQYKDRDGQSQVVPVDGSHRE--- 2150

  Fly  2525 QTSIGFIRCTYTPPGSTRAYLQHYSHAGALLQTILPG--DGARIVYRYNAAGQLTEVVHGDGRSE 2587
                  :|.:...||  |.|           :.:|.|  |..|:       |.|:.:...|.|  
Mouse  2151 ------VRVSGLDPG--RRY-----------KLLLYGLRDSKRV-------GPLSVIAVTDPR-- 2187

  Fly  2588 FQYNEA-TGMPSTVSHTERELEYRWDFEYAAGLLAEERID----------YVAKTGLSNAKFSYE 2641
             :..|| |.:|:|.:..            |...|.|.|::          :|...|..|: |..:
Mouse  2188 -ETTEAWTEVPTTSTPA------------AVPRLGELRVEEATPHSLHLSWVVTEGEFNS-FEVQ 2238

  Fly  2642 Y---DSQLRVVALQG--------------------------------RIGGQSLP-----TQAFA 2666
            |   |.||||.:.:|                                :|...::|     .:..:
Mouse  2239 YTDRDGQLRVASTEGDQTDITLTGLESNHRYLITLYGFHDGQPVGSAQIEALTVPWEEEEEEEES 2303

  Fly  2667 YDPRTGRPSLIGQFRFSQPAQNQTQLHDGT---ASFTRTV-DGRF------------QTQRMALA 2715
            .:|.|..|.       .:|...:..:.|.|   .|.:.|| :|:|            |.:.:.:.
Mouse  2304 TEPPTMTPE-------PRPQLGELTVTDATPDSLSLSWTVPEGQFDQFVIQYKNGDGQPKVVRVP 2361

  Fly  2716 IHRLEV----------FRMEFSYGVHG--RISQTRTYTRNMAVNSYTNVKNYTWDCDGQLVGVEA 2768
            .|..:|          :::.. ||:|.  |.....|.....||....:...         ...||
Mouse  2362 GHEDQVTISGLEPDHKYKLNL-YGIHSGQRFGPVSTVGVTAAVEEPPSPTE---------PSTEA 2416

  Fly  2769 QEPWGFRYDDNGNLLSLTYRGN---------TIPMEYNAQDRIVKFGEGQYK-YDARGLVAQNAR 2823
            .||     .:...|..||..|:         |:|     |.....| ..||| .|.|..|.:...
Mouse  2417 PEP-----TEEPLLGELTVTGSSPDSLSLSWTVP-----QGDFDSF-TVQYKDSDGRPQVMRVGG 2470

  Fly  2824 EERFHYNTQGLLVRASKRGR-FDVRYYYDHLKRLTTRKDNFGNVTQFFYTN-QQRPYEVSQIYSP 2886
            :||      .::||....|| :.:..|..|..|      ..|.|:....|: ::.|.:.|.: .|
Mouse  2471 QER------EVIVRDLDPGRKYKMNLYGLHEGR------RVGPVSTVGVTDPKEEPTDASSL-KP 2522

  Fly  2887 RDGKLMSLTYDDVGHLIYAQVYRHKYYVATDQS-----GTPLMLFNQY------GEGIREIMRSP 2940
            |   |..||..|                ||..|     ..|...|:|:      |:|..:::|.|
Mouse  2523 R---LEELTVTD----------------ATPDSLSLSWTVPEGQFDQFVIQYKNGDGQPKVVRVP 2568

  Fly  2941 FGHIVYDSNPYLYLPIDFCGGILDQVTTL----VHMGDGRVYDPLIGQWMSP----DWQRVAERI 2997
             ||                   .||||..    .|.....:|....||.:.|    ......|..
Mouse  2569 -GH-------------------EDQVTISGLEPDHKYKMNLYGIYSGQRVGPVSAVGVTAAEEEP 2613

  Fly  2998 ITPT-------------------RLHLYRFNGNDPINVGHERHYPE-DFAAWMRTLGYNVGNLVP 3042
            .:||                   ||......|:.|.::......|: ||.::  |:.|...:..|
Mouse  2614 PSPTEPRTEAPEPTEAPEPTEEPRLGELTVTGSSPDSLSLSWTIPKGDFDSF--TVQYKDSDGRP 2676

  Fly  3043 QLARDLWQPPALWGR--PPANPVALNL------RR--PFDNIPTMAVESGFLAHLNVRRMSDFEQ 3097
            |:.|...|...:..|  .|.....:||      ||  |...|...|.|...|....|...:.   
Mouse  2677 QVIRVRGQEREVIVRDLDPGRKYKMNLYGLHEGRRVGPVSTIGVTAPEEEALTTQAVPTTTP--- 2738

  Fly  3098 LSAPPRSAL--KCDVMDPSPKTIG---SDTEPPFGKGIVVSRTADGQAIVSSVP 3146
             ..||:...  :..|.|.:|.::.   :..|..|.:.::..:..|||..|..||
Mouse  2739 -EPPPKKPHLGELTVTDATPDSLSLSWTVPEEQFDQFVIQYKNGDGQPKVVRVP 2791

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ten-aNP_001162732.2 EGF_2 934..960 CDD:285248 14/25 (56%)
Keratin_B2 998..1162 CDD:279797 62/169 (37%)
EGF_2 <1003..1025 CDD:285248 9/21 (43%)
EGF_2 1032..1057 CDD:285248 10/24 (42%)
EGF_2 <1071..1095 CDD:285248 8/23 (35%)
EGF_2 1101..1126 CDD:285248 13/24 (54%)
EGF_2 <1135..1157 CDD:285248 8/21 (38%)
EGF_CA 1163..1192 CDD:238011 10/33 (30%)
NHL 1622..1927 CDD:302697 67/419 (16%)
NHL repeat 1675..1721 CDD:271320 7/55 (13%)
NHL repeat 1745..1787 CDD:271320 14/62 (23%)
NHL repeat 1802..1847 CDD:271320 14/83 (17%)
NHL repeat 1864..1897 CDD:271320 7/42 (17%)
RHS_repeat 2213..2250 CDD:283287 9/52 (17%)
RhsA 2397..2958 CDD:225750 137/688 (20%)
Rhs_assc_core 2939..3015 CDD:274730 19/102 (19%)
Tox-GHH 3274..3349 CDD:292269
TnxbXP_006525248.1 EGF_2 172..200 CDD:285248
EGF_2 203..231 CDD:285248
EGF_Tenascin 236..262 CDD:376143
EGF_Tenascin 267..293 CDD:376143
EGF_Tenascin 298..325 CDD:376143
EGF_Tenascin 329..356 CDD:376143
EGF_Tenascin 360..386 CDD:376143
EGF_2 389..417 CDD:285248
EGF_Tenascin 422..448 CDD:376143
EGF_2 451..479 CDD:285248 14/26 (54%)
EGF_2 482..510 CDD:285248 9/27 (33%)
DSL <498..541 CDD:366627 16/46 (35%)
EGF_2 541..572 CDD:285248 12/31 (39%)
EGF_Tenascin 577..604 CDD:376143 10/28 (36%)
EGF_2 608..634 CDD:285248 14/25 (56%)
EGF_Tenascin 639..665 CDD:376143 9/25 (36%)
EGF_Tenascin 706..732 CDD:376143 4/29 (14%)
fn3 737..818 CDD:365830 10/80 (13%)
fn3 830..906 CDD:365830 20/121 (17%)
fn3 1074..1142 CDD:365830 10/67 (15%)
fn3 1295..1369 CDD:365830 20/129 (16%)
FN3 1386..1466 CDD:238020 8/82 (10%)
fn3 1484..1558 CDD:365830 13/73 (18%)
fn3 1599..1674 CDD:365830 18/89 (20%)
fn3 1707..1782 CDD:365830 18/100 (18%)
fn3 1804..1874 CDD:365830 13/78 (17%)
fn3 1904..1971 CDD:365830 21/103 (20%)
fn3 2000..2067 CDD:365830 17/83 (20%)
fn3 2102..2164 CDD:365830 16/83 (19%)
FN3 2211..2279 CDD:238020 12/68 (18%)
fn3 2315..2393 CDD:365830 15/78 (19%)
fn3 2426..2496 CDD:365830 21/81 (26%)
fn3 2525..2600 CDD:365830 23/110 (21%)
fn3 2639..2709 CDD:365830 15/71 (21%)
fn3 2748..2823 CDD:365830 11/44 (25%)
fn3 2861..2931 CDD:365830
fn3 2970..3043 CDD:365830
fn3 3076..3146 CDD:365830
fn3 3183..3258 CDD:365830
fn3 3291..3361 CDD:365830
fn3 3387..3462 CDD:365830
fn3 3480..3542 CDD:365830
fn3 3569..3649 CDD:365830
fn3 3679..3752 CDD:365830
fn3 3776..3855 CDD:365830
fn3 3875..3953 CDD:365830
FN3 3962..4048 CDD:238020
fn3 4052..4129 CDD:365830
Fibrinogen_C 4143..4352 CDD:278572
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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