Protein Alignment Ten-a and TNC

DIOPT Version :10

• Sequence 1: NP_001162732.2
• Gene: Ten-a / 32183
• FlyBaseID: FBgn0267001
• Length: 3387
• Species: Drosophila melanogaster
• Sequence 2: NP_001425994.1
• Gene: TNC / 3371
• HGNCID: 5318
• Length: 2384
• Species: Homo sapiens
• Alignment Length: 2710
• Identity: 542/2710 - (20%)
• Similarity: 861/2710 - (31%)
• Gaps: 1045/2710 - (38%)

  Fly   788 FVEFI----KGGRLDSHLRHRR-SSANATTTGQDM-----ELYRQDKDQSAESAQDQDS---EQD 839
            |:.|:    :||.|...:||:| |..|||...::.     .:|.......::.:.|.:|   |:|
Human    12 FLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKD 76

  Fly   840 ESRSFDSSESYDVETPLDTAKQ--HLQRIGKPQSHWVNKRSAGDGLPALDVDAMTVNVSLLQYLD 902
            .:...:.|||:...| :|...|  ...||..|      :|:.|.. .|.||..:...:..|:.|.
Human    77 LAPPSEPSESFQEHT-VDGENQIVFTHRINIP------RRACGCA-AAPDVKELLSRLEELENLV 133

  Fly   903 TGLW----------------------FIS------------------------------------ 909
            :.|.                      |.|
Human   134 SSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRG 198

  Fly   910 -------VYNDELVAHSVSLLAEEAEGVSTTCPNDCSGRGSCYLGKCDCIDGYQGVDCSKSVCPV 967
                   :.:|.......|.||         ||:||:.:|.|..|.|.|.:||.|.|||:.:|||
Human   199 RCIDGQCICDDGFTGEDCSQLA---------CPSDCNDQGKCVNGVCICFEGYAGADCSREICPV 254

  Fly   968 LCS-AHGHYGGGVCHCEEGWKGAECDIPVGECEVPNCSSHGRCIEGECHCERGWKGPYCDQ---- 1027
            .|| .||....|:|.|.:|:.|.:|:.|:  | :.||.:.|||:|.||.|:.|:.|..|.:
Human   255 PCSEEHGTCVDGLCVCHDGFAGDDCNKPL--C-LNNCYNRGRCVENECVCDEGFTGEDCSELICP 316

  Fly  1028 HDCLDPLCSGHGTCVAGQCYCKAGWQGEDCGTIDQQVYQCLPGCSEHGTYDLETGQCVCERHWTG 1092
            :||.|     .|.|:.|.|||:.|:.|||||.     ..|...|...|.  .|.|||||:..:.|
Human   317 NDCFD-----RGRCINGTCYCEEGFTGEDCGK-----PTCPHACHTQGR--CEEGQCVCDEGFAG 369

  Fly  1093 PDCSQAVCSLDCGRNGVCESGKCRCNSGWTGNLCDQLPCDSRCSEHGQCKNGTCVCSQGWNGRHC 1157
            .|||:..|..||...|.|..|:|.|:.|:||..|.:|.|.:.||.||:|.||.|||.:|:.|..|
Human   370 VDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDC 434

  Fly  1158 TLPGCENGCSRHGQCTLENGEYRCDCIEGWAGRDCSIALELNCKDNIDNDG----------DGMT 1212
            :...|.|.|...|:|.    |.:|.|.:|:.|.|||   :::|.::....|          ||.|
Human   435 SQLRCPNDCHSRGRCV----EGKCVCEQGFKGYDCS---DMSCPNDCHQHGRCVNGMCVCDDGYT 492

  Fly  1213 --DCSDSEC---CSH-----------------PACSEHIMCLSSNDPVEVLLRKQPPSVTASFYQ 1255
              ||.|.:|   ||:                 |.|:| :.|  .||     ...|...|......
Human   493 GEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAE-LSC--PND-----CHGQGRCVNGQCVC 549

  Fly  1256 RVKFL---IEENSVQSYAH-----MDEYSENLFWSSFT--PCRVSVMRGQVITPQGLGIVGIRVS 1310
            ...|:   .:|....|..|     :|  .:.:....||  .|      ||...|.....:|..||
Human   550 HEGFMGKDCKEQRCPSDCHGQGRCVD--GQCICHEGFTGLDC------GQHSCPSDCNNLGQCVS 606

  Fly  1311 VDRDSRFGFTLTRQGGWFDVLVNGGGAVTLQFQRSPFRPLT------RTVFVPWNR-------IV 1362
                   |..:..:|      .:|.....:    ||.:.|.      .||.:.|:.       :|
Human   607 -------GRCICNEG------YSGEDCSEV----SPPKDLVVTEVTEETVNLAWDNEMRVTEYLV 654

  Fly  1363 VLPP-----VQMQLSDDDETTSRNIKVAPLNPALTFLNSIHYHTADEANDASKVCMDHDHEKLRP 1422
            |..|     ::||.....:.||..|:  .|.|.:.:.              .:|....:::|..|
Human   655 VYTPTHEGGLEMQFRVPGDQTSTIIQ--ELEPGVEYF--------------IRVFAILENKKSIP 703

  Fly  1423 --QLISTWMPNGVGAMPGKRVIFAETQIVQESIQIPGSDLHLTYQ---------SSQASGYLSIV 1476
              ..::|::|    |..|.:.    ..|.:.|:::....|.:.::         :.:..|.::..
Human   704 VSARVATYLP----APEGLKF----KSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKS 760

  Fly  1477 RMRLTGETIPPT---LTHVHVGVEIEGALH-VKTYEADPSLVHTFAWNKRNVYRQKVYGVTVARI 1537
            ..|      |.|   .|.:..|.|.|.:|| ||.....|.|       ||         ||..|:
Human   761 LRR------PETSYRQTGLAPGQEYEISLHIVKNNTRGPGL-------KR---------VTTTRL 803

  Fly  1538 SVGYQ------HSTCQSPVWIAQTAKLQGYD--------------VDISD------IGGWGLDIH 1576
            ....|      ..|.....|....|::.|.:              :|:::      ||....|..
Human   804 DAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTE 868

  Fly  1577 HHYNFHEGILQKGDGSTLHMKE-------YPR--------------------------------- 1601
            :..:.   |.::||.|:...||       .||
Human   869 YEVSL---ISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPI 930

  Fly  1602 ----------------TVKVVMGTGLQRPLTCPDYCNGVA----------------------KDA 1628
                            |.|..: ||| ||.|  :|..||:                      ||.
Human   931 SGGDHAEVDVPKSQQATTKTTL-TGL-RPGT--EYGIGVSAVKEDKESNPATINAATELDTPKDL 991

  Fly  1629 KL------------LTPIA----------LATGPDGSLYVGDFNLVRRIT-------PDGKVYTI 1664
            ::            .||:|          |.||.    :|| ..|.|..|       ..|:.|.:
Human   992 QVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQ----WVG-VQLPRNTTSYVLRGLEPGQEYNV 1051

  Fly  1665 L--------------------------QLSATQVSYQ----YYLAVSPADGHLYISDPERHQI-- 1697
            |                          .|:.|:|.:.    .:.|...|..|..|...|.:::
Human  1052 LLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEA 1116

  Fly  1698 ---------LRLVRLEKVKDPSINSDPVVG--SGQR-------CIPGDEGNCGD------GGPAL 1738
                     ||.|.:..:|..:..:..:.|  .|.|       ...|:..|.|:      |..||
Human  1117 ARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDAL 1181

  Fly  1739 LARLSHPKGL------------AIAADRTMYIADGTNIRAVDPKGV---IHTLIGHHGHHNHWSP 1788
            ....:.|:|.            .:.|.:.:.:..|  :|:.|..|:   .|..|...|....:|.
Human  1182 KLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGG--LRSTDLPGLKAATHYTITIRGVTQDFST 1244

  Fly  1789 APCS-----------GTLMANQA-----QLQWPTGLALSPLDGSLHFIDDRLVLR---------- 1827
            .|.|           |.|...:.     :|.|.|.      ||:.    |:..::
Human  1245 TPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTP------DGTY----DQFTIQVQEADQVEEA 1299

  Fly  1828 --LTSDMKIRVV------AGTP----LH---------------------------CSNGGQDG-R 1852
              ||....:|.:      ||||    ||                           .|..|.|| |
Human  1300 HNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLR 1364

  Fly  1853 VNKTGADNVL----------------------GTVLAM------AFSPF---------------- 1873
            :|.|.|||..                      |::.|:      |.:|:
Human  1365 LNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVL 1429

  Fly  1874 ------------GNLYIADSDSRRVN-------------SIRVVDTAGNMRYFAGKQEGTGSQTC 1913
                        |||.::|......|             :|.::|:...:            :|.
Human  1430 SAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLL------------ETV 1482

  Fly  1914 DCAIGGGSNGSATNSG----------VGGAGGSAYSTTVNPTRPNGGTTPTTP----------SG 1958
            :..|.|... :|..||          :.|...|..:.|::.|    .||...|          :.
Human  1483 EYNISGAER-TAHISGLPPSTDFIVYLSGLAPSIRTKTISAT----ATTVAKPLLSHLTVSNMTW 1542

  Fly  1959 GNGNGNGNGSSATSSGGSVGGSNGSGGGANGGACICAGGIALSTG-TGSSSGSNGGGTLASIVGS 2022
            |:.:.:.....:......:..||..  ..:....:...|::.|:. |...:.||....|..::|
Human  1543 GSVSISWEAQESAFDSFLIEVSNSD--HPHETMVLSVPGVSRSSVITNLKASSNYTAHLHGLIG- 1604

  Fly  2023 GGLMSTGPTTTTTVLLGAKTTAAGIGAATLNDDGTLSNAETLLSSNARFQAISAIAVAQDG---- 2083
                  |....|.::.........:|              ||:.||...::.:.....|.|
Human  1605 ------GQRAQTLMVQATTEPKPQLG--------------TLIFSNITPKSFNMSWTTQAGLFAK 1649

  Fly  2084 -VINVADQGSLHVLALEHYLPSHD----------ENGEFHI----------PFPPSSEIYV---- 2123
             ||||:|..|||  ..:.:..|.|          ||..:.:          |..|.:...:
Human  1650 IVINVSDAHSLH--ESQQFTVSGDAKQAHITGLVENTGYDVSVAGTTLAGDPTRPLTAFVITEAL 1712

  Fly  2124 ----------FNRYGQHVA-----------------------TKDLT-SGKTRYSFLYSKNTSFG 2154
                      .|.||..|:                       .::.| ||..|...|....|..|
Human  1713 PLLENLTISDINPYGFTVSWMASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIG 1777

  Fly  2155 -----------------RLSTVTDA--------------SGNKIQFLRD---YSNVVSSIENTQD 2185
                             |...||:|              .|.::.:..|   :.|.|..|.:|:.
Human  1778 YEVMVSGFTQGHQTKPLRAEIVTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKK 1842

  Fly  2186 HKSEIQINGIG-----IMTKLSEKGRQEIEL-----------------------------DYDSN 2216
            ....::|..:.     .:|.|.|....||||                             |...|
Human  1843 QSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITEN 1907

  Fly  2217 TGLLNSRSSGGETYIYQYDEFGRVTGMILPSGEIVRITSQLADSQGLTVYVHASVESLFSRERIA 2281
            :..::.|:...     |.:.| |:|.:.:..|....:|.....:|...|.:...||.|.|
Human  1908 SATVSWRAPTA-----QVESF-RITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVS----- 1961

  Fly  2282 GEANELLVLGGVRSTFLKRGQAHADAELKANNTLVIHGDNGVVVEASAVARHPLLEAALPVEAEM 2346
                 ::.:.|...:          ..:..:.|..:.|.:|:|             .|...::|.
Human  1962 -----IIAMKGFEES----------EPVSGSFTTALDGPSGLV-------------TANITDSEA 1998

  Fly  2347 LAMWSHQSVTMGEGLTNSMYSVYSLVGDVRNPQQTLNREIWVNQSRVIGVEFDQFTNRETFYDAR 2411
            ||.|.....|:..       .|.|..|: :.|:  :.|.:..|.     ||: ..|:.|
Human  1999 LARWQPAIATVDS-------YVISYTGE-KVPE--ITRTVSGNT-----VEY-ALTDLE------ 2041

  Fly  2412 RTPILIVAYDQSGLPKSYYPTNGYPVNITYDRFNRVEGWAWGPAELKYSYDRHGLLSEITSQQDG 2476
                               |...|.:.|..::         ||.  |.|.......:::.|.:|.
Human  2042 -------------------PATEYTLRIFAEK---------GPQ--KSSTITAKFTTDLDSPRDL 2076

  Fly  2477 IVSFVYNDWNLVS-EIGLASQRKFVLQYDDAGG-LRHVVL-PSGTRHSFS--------------- 2523
            ..:.|.::..|:: ....||...::|.|:...| ::.|:: |..|.:|.:
Human  2077 TATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQAL 2141

  Fly  2524 --------MQTSIGFIRCTYT-PPGSTRAYLQHYSHAGALLQTI-LPGDGARIVYRY-----NAA 2573
                    :||....|...|. |...::|.|...:.:|  |.|| |.||.|..:..:     :..
Human  2142 NGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSG--LYTIYLNGDKAEALEVFCDMTSDGG 2204

  Fly  2574 GQLTEVVHGDGRSEFQYNEATGMPSTVSHTERELEYRWDFEYAAGLLAEERIDYVAKTGLSNA-K 2637
            |.:..:...:||..|..|                   |. .|||| ..:.|.::  ..||.|. |
Human  2205 GWIVFLRRKNGRENFYQN-------------------WK-AYAAG-FGDRREEF--WLGLDNLNK 2246

  Fly  2638 FSYEYDSQLRVVALQGRIGGQSLPTQAFA-YDPRTGRPSLIGQFRFSQPAQNQTQLHDGTASFTR 2701
            .:.:...:|||   ..|..|::    ||| ||            :||        :.|....:..
Human  2247 ITAQGQYELRV---DLRDHGET----AFAVYD------------KFS--------VGDAKTRYKL 2284

  Fly  2702 TVDGRFQTQRMALAIHRLEVFRMEFSYGVHGRISQTRTYTRNMAV-NSYTNVKNYTW--DCDG-Q 2762
            .|:|...|...::|.|             :||...|.....:.|: |...:.|...|  :|.. .
Human  2285 KVEGYSGTAGDSMAYH-------------NGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVN 2336

  Fly  2763 LVGVEAQEPWGFRYDDNGNLLSLTYRGNTIPMEYNAQDRIVKFGE 2807
            |:|         ||.||.:...:.:      ..:...:..::|.|
Human  2337 LMG---------RYGDNNHSQGVNW------FHWKGHEHSIQFAE 2366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ten-a	NP_001162732.2	acid_disulf_rpt	1199..1225	CDD:411265	12/57 (21%)
		NHL	1622..1927	CDD:302697	94/561 (17%)
		NHL repeat	1675..1721	CDD:271320	10/62 (16%)
		NHL repeat	1745..1787	CDD:271320	10/56 (18%)
		NHL repeat	1802..1847	CDD:271320	16/93 (17%)
		NHL repeat	1864..1897	CDD:271320	10/79 (13%)
		RHS_core	<2118..>2248	CDD:469161	36/235 (15%)
		RhsA	<2366..3015	CDD:442442	94/481 (20%)
		Tox-GHH	3272..3349	CDD:464783
		EGF_2	937..960	CDD:400365	10/22 (45%)
		EGF_2	1003..1025	CDD:400365	10/21 (48%)
		EGF_2	1034..1057	CDD:400365	9/22 (41%)
		C_rich_MXAN6577	<1035..1146	CDD:469225	46/110 (42%)
		EGF_CA	1163..1192	CDD:238011	9/28 (32%)
TNC	NP_001425994.1	None