DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ten-a and fn1b

DIOPT Version :9

Sequence 1:NP_001162732.2 Gene:Ten-a / 32183 FlyBaseID:FBgn0267001 Length:3387 Species:Drosophila melanogaster
Sequence 2:XP_009303829.1 Gene:fn1b / 334613 ZFINID:ZDB-GENE-030131-6545 Length:2500 Species:Danio rerio


Alignment Length:2569 Identity:479/2569 - (18%)
Similarity:763/2569 - (29%) Gaps:979/2569 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   830 SAQDQDSEQDESRSFDSSESYDVETPLDTAKQHLQRI--GKPQSHW-VNKRSAGDGLPALDV-DA 890
            :::::.::||...|:...|::   :.:|::...||.:  |..:..| .::.:|...:||:.. .|
Zfish   230 TSRNRCNDQDTRTSYRIGETW---SKIDSSGHTLQCLCTGNGRGEWKCDRHAASHVIPAIGTGSA 291

  Fly   891 MTVNVSLLQYLDTGLWFISVYNDELVAHSVSLLAEEAEGVSTTCPNDCSGRGSCYLGK------- 948
            :|..|:                  .|.:.|::|.|..|  ...|..| || .|.|.|.       
Zfish   292 VTHRVT------------------PVMNQVNVLNELIE--EGNCKTD-SG-VSYYNGMSWIRTQG 334

  Fly   949 -----CDCIDGYQGVDCSKS----------------VCPVLCSAHGHYGGGVCHCEEGWKGAECD 992
                 |.|:.|  |:.|.:.                |.|.:.|.:.||                 
Zfish   335 TKEMLCTCVGG--GISCEEQDGQSQVYGGNSGGQPCVFPFVFSGNTHY----------------- 380

  Fly   993 IPVGECEVPNCSSHGRCIEGECHC----ERGWKGPY--CDQHDCLDPLCSGHGTCVAGQCYCKAG 1051
                     :|.|.||. :|:..|    :....|.|  |.|.:.|  :.:..|......|.....
Zfish   381 ---------SCISEGRS-DGQLWCSTTSDYDSDGLYSFCTQKNLL--VTTRGGNSNGALCQFPFK 433

  Fly  1052 WQGE---DC---GTIDQQVYQCLPGCSEHGTYDLET--GQCVCERHWTGPDCSQAVCSL------ 1102
            :.|.   ||   |..|...:     |.....||.|.  |.|....|       :.||::      
Zfish   434 YNGRNYTDCTAEGRRDGMKW-----CGTTADYDREQKYGFCPMAAH-------EEVCTVNDVMYR 486

  Fly  1103 -----DCGRNGVCESGKCRCNSGWTGNLCDQLPCDSRCSEHGQCK-----NG-TCVCSQGWNGRH 1156
                 |...:.:....:|.|.....|        :..|..|.|.|     || |...::.::.||
Zfish   487 VGDEWDKRHDTLGHMMRCTCQGNGRG--------EWNCISHTQLKDQCVVNGQTYDVNETFDKRH 543

  Fly  1157 -------CTLPGCENG---CSRHGQC-----------------TLENGEYRCDCIEGWAGRDCSI 1194
                   ||..|...|   |....||                 .::...|||.|.          
Zfish   544 DQGYMMNCTCFGQGRGRWKCDAIDQCQEPETKVFYQIGQTWNKVIQGTPYRCSCY---------- 598

  Fly  1195 ALELNCKDNIDNDGDGMTDCSDSECCSHPACSEHIMCLSSNDPVEVLLRK---QPPSVTASFYQR 1256
                         |:|:.:.         ||..    |.|..||.|::.:   ||.|        
Zfish   599 -------------GNGIGEM---------ACEP----LQSTAPVRVIITEAGNQPNS-------- 629

  Fly  1257 VKFLIEENSVQSYAHMDEYSENLFW---SSFTPCRVSVMRGQV-----------ITPQGLGIVGI 1307
              ..|:.|:..| ||:.:|.  |.|   ::.||.:...:.|.:           :|.:|..|..:
Zfish   630 --HPIQWNAPPS-AHITQYI--LKWRVKNTRTPWKEVTIPGHINSYTISGLKAGLTYEGQLISIL 689

  Fly  1308 RVSVDRDSRFGFTLTRQGGWFDVLVNGGGAVTLQFQ----RSPFRPLTRTVFV-PW--------- 1358
            |......:||.||.|     :..|....|..|...|    ......:|...|| .|         
Zfish   690 RYGPREVTRFDFTTT-----YGSLAKAEGETTQPRQVVDTSESVTEITSNSFVISWVSASDTVSG 749

  Fly  1359 -------------NRIVVLPPVQMQLSDDDETTSR--NIKVAPLNP------ALTFLNSIHYHTA 1402
                         .|::.||.....::..|....|  |:.|..:||      .||       .|.
Zfish   750 FRVEYELSEEGAQKRVLDLPRTTTSVNIQDLLPGRRYNVDVYEVNPEGDTKLILT-------TTQ 807

  Fly  1403 DEANDASKVCMDHDHEKLRPQ---LISTW-MPNGVGAMPGKRVIFAETQIVQESIQIPGSDLHLT 1463
            ..|.||..     :||....|   ::..| .|.  ..:.|.||::..:        :.||...|.
Zfish   808 TTAPDAPT-----NHEVSNVQETSIVIRWSKPK--APITGYRVVYTPS--------VEGSSTELI 857

  Fly  1464 YQSSQASGYLSIVRMRLTG-----------ETIPPTLTHVHVG----VEIEGALHVKTYEADPSL 1513
            ...:|.|..|..:|..|:.           |:.|..|.....|    .||:....::.||.....
Zfish   858 LPETQTSVTLGDLRPGLSYNISIYSVEDNLESEPLVLQASTAGEQQPEEIQAPTDLQFYEVTDVK 922

  Fly  1514 VHTFAW----NKRNVYRQKVYGVTVARISV-GYQHSTCQSPVW---IAQTAKLQGYDVDISDIGG 1570
            : |..|    |:.:.||     ||.|.:|. |......|.||.   .|:..:||...:       
Zfish   923 I-TITWTGPPNEVSGYR-----VTFAPVSTDGQAQRPLQLPVTHNAYAELMRLQPGTL------- 974

  Fly  1571 WGLDIHHHYNFHEGILQKG--------------------------DGSTLHMKEYPRT------V 1603
                    |.||...:..|                          |.|.|.:..:||.      :
Zfish   975 --------YRFHIYAVSGGVESEPLIGEKSTKPDAPTDLRFTDITDDSALVIWSFPRAQVTGYRL 1031

  Fly  1604 KVVMGTGLQRPLTCPDYCNGVAKDAKL--LTP-----IALATGPDGSLYVGDFNLVRRITPDGKV 1661
            .:.:|:...:.|..|    |.....||  |.|     :.|.:....:|..|..:..|...|.|..
Zfish  1032 FISIGSSSPKQLRIP----GHKSQYKLPNLQPDTEYRVTLHSEQGNTLSEGITDTFRTTQPTGNA 1092

  Fly  1662 ------YTILQLSATQV---SYQYYLAVSPA------------DGHLYIS--DPERHQILRL--- 1700
                  .|...:..|.:   .:.|.::|.|:            .|.:|||  .|....|..|   
Zfish  1093 PRFNTEVTDTAIIVTWIPVAKFSYRMSVKPSQSGETPREETSGSGRIYISGLTPGLEYIYSLQPL 1157

  Fly  1701 ------------------------------------VRLEKVKDPSINSDPVVG---SGQRCIPG 1726
                                                ||....|.|.|....|.|   :|||.:..
Zfish  1158 FSGRKHGSPITNKVVTSLSPPTDLNVEPNSVNGELNVRWRGTKSPDITGYRVTGTPINGQRGVSL 1222

  Fly  1727 DEGNCGDGGPALLARLS--------------HPKGLAIAADRTMYIADGTNIRAVDPKGVIHTLI 1777
            :|...||....:|..||              |.:...|:...|..:....::..||   ...|.|
Zfish  1223 EESVRGDETSCILENLSPGVDYNISVYTVKNHLESEPISTSVTQDVPKVGDLSFVD---FTDTTI 1284

  Fly  1778 GHHGHHNHWSPAPCSG------TLMAN-----------QAQLQWPTGLALSP---LDGSLHFIDD 1822
            |     ..|:|.....      |::.:           .:.:.:.|...|.|   .|.|:..|.|
Zfish  1285 G-----IRWTPLKYQAVTGYHITVVTSGQNFPILEDVVNSSVNYYTIRGLEPGINYDISVSTITD 1344

  Fly  1823 R---LVLRLTSDMKIRVVAGTPLHCSNGGQDG--------------------RVNKTGAD----- 1859
            .   :...:|...:..|.|.|.|:.|..|.|.                    |.:.|..|     
Zfish  1345 EAESVPSVITQQTQTAVPAPTNLYISEVGADSMHVSWTAPSVQPSEISRFVIRYHPTNNDDDTQE 1409

  Fly  1860 -NVLGTVLAMAFSPFGNL-----YIA-------DSDSRRVNSI---------------------- 1889
             ||.|...:....   ||     |:.       |.:|..|..|                      
Zfish  1410 VNVGGGTTSFVLQ---NLLPNTEYLVKVVCVYDDRESEPVTGIQKTKLDSPTNLDFSDVSTNSFT 1471

  Fly  1890 ------RVVDTAGNMRY----------------------------------------------FA 1902
                  |.|.|...:||                                              ..
Zfish  1472 VHWMAPRAVITGYRLRYQPTSGGRAKDERLPPTRNYFTLVNLAPETEYTVHIYAVSSNIESLPLT 1536

  Fly  1903 GKQEGTGSQTCDCAIGGGSNGSATNSGVGGAGGSAY-----STTVNPTRPNGGTTPTTPSGGNGN 1962
            |.|........|.|:...:..|.|.|....|....|     ..|.....|...|.|.|.|.....
Zfish  1537 GTQATVSDAPTDLAVTSSTPTSITISWDAPAVTVRYYKITHGETGERDAPREFTVPGTQSSATIQ 1601

  Fly  1963 G--------------NGNGSSATSSGGSVGGSNGSGGGANGGACICAGGIALSTGTGSSSGSNGG 2013
            |              .|.|.|..||...:.....:||.....:.:....|..:|.|...:.:.|.
Zfish  1602 GLRPDTDYTITLYAVTGRGDSPASSTPVIITHRTAGGSIASPSDLDVTDIQDNTLTVRWTPARGP 1666

  Fly  2014 GTLASIVGS--GGLMSTGPTTTTTVLLGAKTTAAGIGAATLNDDGTLSNAETLLSSNARFQAISA 2076
            .|...:.|:  ||   .|||.:.  |:|.:.|...|       .|.:...|         ..|:.
Zfish  1667 ITGYRVTGTPKGG---QGPTFSE--LVGPERTEMTI-------HGLVPTVE---------YTINV 1710

  Fly  2077 IAVAQDG----VINVA--------------DQGSLHVLALEHYLPSHDENGEFHIPFPPSSEIYV 2123
            :|::|:|    |:..|              |..|..:|.            ::::|..|      
Zfish  1711 VALSQEGESTPVVQKATTTNEQKPKDLTFTDVDSTSMLV------------KWNVPRVP------ 1757

  Fly  2124 FNRYGQHVATKDLTSGKTRYSFLYSKNTSFGRLSTVTDASGNKIQFLRDYSNVVSSIENTQDHKS 2188
                           |.|.|..|||           :...|.     |:|...:|..:|:     
Zfish  1758 ---------------GVTSYRVLYS-----------SPEEGE-----REYQPALSGRDNS----- 1786

  Fly  2189 EIQINGIG-----IMTKLSEKGR------QEIELDYDSNTGLLNSRSSGGETYIYQYDEFGRVTG 2242
             :.:.|:.     |:..:..|||      :.|:.....:|..:   :....|.|..:|       
Zfish  1787 -VLLQGLNPGTMYIIKVIPMKGRNPLQTLEGIQQTIQEDTQRI---AVPAPTDIQFFD------- 1840

  Fly  2243 MILPSGEIVRITSQLADSQGLTVYVHASVESLFSRE-RIAGEANELLVLGGVRST------FLKR 2300
             |.||..||...:..:...|..|.|....:...|:| .|:.::.::||.|.|.:|      :..|
Zfish  1841 -ISPSSFIVSWQAPNSRLSGYRVVVTPRNQLATSKEMTISPDSTQVLVPGLVVATPYNVHVYALR 1904

  Fly  2301 GQ----------AHAD----------AELKANN-TLVIHGDN-----GVVVEASAV-ARHPLLEA 2338
            |.          ..||          :::|..: ||.....|     |.::||:.. ..:|....
Zfish  1905 GSDSSPPLTGEITTADNITPPRRVRISDVKDTSFTLAWRAVNNEPMTGFLIEATPKNGGYPTFRQ 1969

  Fly  2339 ALPVEAEMLAMWS-HQSVTMGEGLTNSMY--SVYSLVGDVRNPQQTLNREIWVNQSR-----VIG 2395
            .:|.:.....:.. |..|         ||  ::|::.|::|:|..|:.    ||.:|     ...
Zfish  1970 TIPSDRRTYVVTGLHPGV---------MYVVNMYTVNGNMRSPPFTMT----VNTARPAVQSPTN 2021

  Fly  2396 VEFDQFTNRETFYDARRTPILIVAY-----DQSGLPKSYYPTNGYPVNITYDRFNRVEGWAWGPA 2455
            ::|...|.....:..:..|..|..|     :..|.|:..:|.|....|                 
Zfish  2022 LQFTSLTPNSISFTWQAPPTHITGYYITYEESGGSPRELFPRNNVGQN----------------- 2069

  Fly  2456 ELKYSYDRHGLLSEITSQQDGIVSFV--YNDWNLVSEIGLASQRKFVLQYDDAGGLRHVVLPS-G 2517
                    :..::.:....:.|:..:  .|:......:|.|:.:..       .||..  ||| |
Zfish  2070 --------YATIAGLKPGTEYIIKIIALLNNQRSAPLVGTATTQLI-------SGLPS--LPSHG 2117

  Fly  2518 TRHSFSMQTSIGFIRCTYTPPG--STRAYLQHYSHA-------------------------GALL 2555
            .|....:......|. |..|.|  ||.|:.||..:.                         ....
Zfish  2118 GRDKLDVPEPDNRIN-TVGPTGHDSTDAHGQHVEYTEYNNQPKQPNIGYQPQNRQPISQPNQPRP 2181

  Fly  2556 QTILPGDGARIVYRYNA---AGQLTEVVH-----GDGRSEFQYNEATGMPSTVSHTERELEYRWD 2612
            |..:|..|..:||....   .|::.:::.     |||.:.....:.||.|.. :.|:..:.:: .
Zfish  2182 QPYVPQVGETLVYVPQVGPDGGRVPQIIQVSERPGDGHTFGFPEDRTGRPQE-AQTQTTISWQ-P 2244

  Fly  2613 FEYAAGLLA-------------EERIDYVAKT----GLSNAKFSYEYDSQLRVVALQGRI----- 2655
            |:.::..|.             :.|:...:.|    ||::.. ||    .:.|.||:|.:     
Zfish  2245 FQQSSAYLVSCQPITHPDEKMFQMRVPGTSTTATLIGLTSGA-SY----NVIVEALKGALKHKIL 2304

  Fly  2656 -----GGQSLPTQAFAYDPRTGRPSLIGQFRFSQPAQNQTQLHDGTASFTRTVDGRFQTQRMALA 2715
                 .|.::|.     |..:.:.|....|..:.        ||..|.:.|..|..|:.....|.
Zfish  2305 EEVVTAGNTVPG-----DATSSKDSCYDTFTATH--------HDVGAEWERMSDTGFKLWCRCLG 2356

  Fly  2716 I---HRLEVFRMEFSYGVHGRISQTRTYTRNMAVNSYTNVKNYTWDCDGQLVGVEAQEPWGFRYD 2777
            :   |    ||.:.|...|.            :.|:|.             :|    |.|. |..
Zfish  2357 LGSGH----FRCDSSKWCHD------------SGNNYR-------------IG----EKWE-RRA 2387

  Fly  2778 DNGNLLSLTYRGNTIPMEYNAQDRIVKFGEGQYK 2811
            :||:|:|.|..||               |:|::|
Zfish  2388 ENGHLMSCTCLGN---------------GKGEFK 2406

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ten-aNP_001162732.2 EGF_2 934..960 CDD:285248 11/37 (30%)
Keratin_B2 998..1162 CDD:279797 42/201 (21%)
EGF_2 <1003..1025 CDD:285248 8/27 (30%)
EGF_2 1032..1057 CDD:285248 3/27 (11%)
EGF_2 <1071..1095 CDD:285248 7/25 (28%)
EGF_2 1101..1126 CDD:285248 4/35 (11%)
EGF_2 <1135..1157 CDD:285248 9/34 (26%)
EGF_CA 1163..1192 CDD:238011 8/48 (17%)
NHL 1622..1927 CDD:302697 88/525 (17%)
NHL repeat 1675..1721 CDD:271320 17/101 (17%)
NHL repeat 1745..1787 CDD:271320 7/41 (17%)
NHL repeat 1802..1847 CDD:271320 13/50 (26%)
NHL repeat 1864..1897 CDD:271320 10/72 (14%)
RHS_repeat 2213..2250 CDD:283287 7/36 (19%)
RhsA 2397..2958 CDD:225750 88/488 (18%)
Rhs_assc_core 2939..3015 CDD:274730
Tox-GHH 3274..3349 CDD:292269
fn1bXP_009303829.1 FN1 57..93 CDD:238018
fn1 101..139 CDD:278468
fn1 145..183 CDD:278468
FN1 190..234 CDD:214494 0/3 (0%)
fn1 235..274 CDD:278468 9/41 (22%)
FN2 361..409 CDD:128373 13/74 (18%)
FN2 421..469 CDD:128373 12/52 (23%)
fn1 478..516 CDD:278468 5/45 (11%)
fn1 529..563 CDD:278468 9/33 (27%)
fn1 569..607 CDD:278468 7/69 (10%)
fn3 614..688 CDD:278470 20/86 (23%)
fn3 727..798 CDD:278470 13/70 (19%)
fn3 812..891 CDD:278470 19/93 (20%)
fn3 909..990 CDD:278470 22/101 (22%)
fn3 1000..1077 CDD:278470 15/80 (19%)
fn3 1097..1155 CDD:278470 11/57 (19%)
fn3 1176..1259 CDD:278470 17/82 (21%)
fn3 1269..1351 CDD:278470 15/89 (17%)
FN3 1362..1450 CDD:238020 18/90 (20%)
fn3 1455..1534 CDD:278470 5/78 (6%)
fn3 1544..1625 CDD:278470 17/80 (21%)
fn3 1643..1721 CDD:278470 21/98 (21%)
fn3 1733..1803 CDD:278470 18/124 (15%)
fn3 1831..1911 CDD:278470 21/87 (24%)
fn3 1924..2004 CDD:278470 16/88 (18%)
FN3 2019..2104 CDD:238020 14/109 (13%)
fn3 2236..2298 CDD:278470 12/67 (18%)
fn1 2325..2364 CDD:278468 10/50 (20%)
FN1 2370..2412 CDD:214494 17/82 (21%)
FN1 2413..2452 CDD:238018
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1225
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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