DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ten-a and Tnn

DIOPT Version :9

Sequence 1:NP_001162732.2 Gene:Ten-a / 32183 FlyBaseID:FBgn0267001 Length:3387 Species:Drosophila melanogaster
Sequence 2:NP_808507.2 Gene:Tnn / 329278 MGIID:2665790 Length:1560 Species:Mus musculus


Alignment Length:1671 Identity:320/1671 - (19%)
Similarity:527/1671 - (31%) Gaps:528/1671 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1002 NCSSHGRCIEG--ECHCERGWKGPYCDQHDCLDPLCSGHGTCVAGQCYCKAGWQGEDCGTIDQQV 1064
            :||.||..:..  .|||::||:|..|||..| ...|:|||.||                      
Mouse   141 HCSGHGTFLPETCSCHCDQGWEGADCDQPTC-PGACNGHGRCV---------------------- 182

  Fly  1065 YQCLPGCSEHGTYDLETGQCVCERHWTGPDCSQAVCSLDCGRNGVCESGKCRCNSGWTGNLCDQL 1129
                            .|||||:..:.|.||:.|.|..||..:|||..|.|:|:..:|...|.:.
Mouse   183 ----------------DGQCVCDAPYVGVDCAYAACPQDCSGHGVCVQGVCQCHEDFTAEDCSEQ 231

  Fly  1130 PCDSRCSEHGQCKNGTCVCSQGWNGRHCTLPGCENGCSRHGQCTLENGEYRCDCIEGW------- 1187
            .|...||.:|.|..|.|.|..|:.|     |.|....:..|...|::.|.  ..:..|       
Mouse   232 RCPGDCSGNGFCDTGECYCEMGFTG-----PDCSQVVAPQGLQLLKSTEN--SLLVSWEPSSEVD 289

  Fly  1188 --------AGRDCSIALELNCKDNIDNDGDGMTDCSDSECCSHPACSEHIMCLSSNDPVEVLLRK 1244
                    .|::.:.......|:....|..|:.          |. :::|:.|.:   |:..:..
Mouse   290 YYLLSYYPLGKEQATKQVRVPKEQHTYDITGLL----------PG-TKYIVTLRN---VKKDISS 340

  Fly  1245 QPPSVTASFYQRVKFLIEENSVQSYAHMDEYSE---NLFWSS------FTPCRVSVMRGQVITPQ 1300
            .|..:.|:         .:.:|...|.::|.:|   ::.|.:      :...|...:.||.:|. 
Mouse   341 SPQHLLAT---------TDLAVVGTAWVNEETETSLDVEWENPLTEVDYYKLRYGPLTGQEVTE- 395

  Fly  1301 GLGIVGIRVSVDRDSRFGFTLTRQGGWF--------------DVLVNGGGAVTLQFQRSPFRPLT 1351
                |.:..|.|..||:..|..:.|..:              .:|:||...:.     .|...:|
Mouse   396 ----VTVPKSRDPKSRYDITGLQPGTEYKITVVPIRGDLEGKPILLNGRTEID-----GPTNVVT 451

  Fly  1352 R-----TVFVPWN--RIVVLPPVQMQLSDDDETTSRNIKVAPLNPALTFLNSIH-------YHTA 1402
            .     |..|.|:  |..:...|...::.|.||..   |..|.:.:.|.|..:.       :..|
Mouse   452 NQVTEDTASVSWDPVRADIDKYVVRYIAPDGETKE---KAVPKDQSSTVLTGLKPGEAYKVFVWA 513

  Fly  1403 DEANDASKVCMDHDHEKL----RPQLIST-----------WMPNGVGAMPGKRVIFAETQIVQES 1452
            :..|..||..   |.:.|    .|:.:.|           |.|.....   .|.:.:.|.:..|:
Mouse   514 ERGNQGSKKA---DTKALTEIDSPENLVTDRVTENSLSVSWDPVEADI---DRYVVSYTSVDGET 572

  Fly  1453 IQIPGSDLHLTYQSSQASGYLSIVRMRLTGETIPPTLTHVHVGVEIEGALHVKTYEADPSLVHTF 1517
            .|:|       .:..|.|                ..||.:..|||.:..:..:..:.:....:|.
Mouse   573 KQVP-------VKKDQRS----------------TVLTGLSPGVEYKVYVWAEKGDRESKKANTK 614

  Fly  1518 A----WNKRNVYRQKVYGVTVARISVGYQHSTCQSPVWIAQTAKLQGYDVDISDIGG-------- 1570
            |    .:.:|:...:   ||...:||.          |....|.:..|.|..:...|        
Mouse   615 APTDIDSPKNLVTDQ---VTENTLSVS----------WDPVQANIDRYMVSYTSADGETREVPVP 666

  Fly  1571 --------WGLDIHHHYNFHEGILQKGDGSTLHMKEYPRTVKVVMGTGLQRPLTCPDYCNGVAKD 1627
                    .||.....|..|.. .|||       .:..|.......|.:..|       ..:..|
Mouse   667 KEKSSTVLTGLRPGVEYKVHVW-AQKG-------TQESRKANTKAPTDIDGP-------KNLVTD 716

  Fly  1628 AKLLTPIALATGP-DGSLYVGDFNLVRRITPDG----------KVYTILQLSATQVSYQYYL--- 1678
            ....|.::::..| :..:   |..:||..:|||          |..|:|:.....|.|:..:   
Mouse   717 QVTETTLSVSWDPVEADI---DRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQ 778

  Fly  1679 ----------AVSPADGHLYISDPERHQILRLVRLEKVKD--PSINSDPVVGSGQRCIPGDEGNC 1731
                      ..:|.|    |..|:     .|| .|:|.:  .:::.|||.....|.:       
Mouse   779 KGAQDSRKANTKAPTD----IDSPK-----NLV-TEQVTESTATVSWDPVEADIDRYV------- 826

  Fly  1732 GDGGPALLARLSHPKG----LAIAADRTMYIADGTNIRAVDPKGVIHTLIGHHGHHNHWSPAPCS 1792
                    .|.:...|    ..:..|:|..:..|..      .||.:.:       :.|:.   .
Mouse   827 --------VRYTSVDGETREFLVGKDQTSTVLTGMR------PGVEYQV-------DVWAQ---K 867

  Fly  1793 GTLMANQAQLQWPTGLALSPLDGSLHFID-------------------DRLVLRLTS-------- 1830
            ||..:.:...:.||     .:||..:.:.                   ||.::|.||        
Mouse   868 GTQESRKTSTKAPT-----DIDGPKNLVTDQVTETTLSVSWDPVEADIDRYMVRYTSPDGETKEV 927

  Fly  1831 ----DMKIRVVAG--------TPLHCSNGGQDGRVNKTGA------------DNVLGTVLAMAFS 1871
                |....|:.|        ..:....|.||.|...|.|            |.|..|.|::::.
Mouse   928 PVSKDKSSTVLRGLRPGVEYKVDVWAQKGAQDSRKANTKAPTDIDSPKNLAIDQVTETTLSVSWD 992

  Fly  1872 PFGNLYIADSDSRRVNSIRVVDTAGNMRYF-AGKQEGTGSQTCDCAIGGGSNGSATNSGVGGAGG 1935
            |..    ||.| |.|  :|.....|..:.| .||::.:      ..:.|...|......|....|
Mouse   993 PVQ----ADID-RYV--VRYTSADGESKEFLIGKEQRS------TVLTGLRPGVEYKVEVWAQKG 1044

  Fly  1936 SAYSTTVNPTRPNGGTTPTTPSGGNGNGNGNGSSATSSGGSV---------------GGSNGSGG 1985
            :..|...|   ..|.|...:|.....| ....::||.|...|               |.:.....
Mouse  1045 ARESKKAN---TEGHTDIDSPKNLVTN-QVTENTATISWDPVQADIDRYMVRYTSADGETREIPV 1105

  Fly  1986 GANGGACICAG---GIALSTGTGSSSG---SNGGGTLA-SIVGSGGLMSTGPTTTTTVLLGAKTT 2043
            .....:.:..|   |:..:....:..|   |....|.| :.:.|...:.|...|..|..:.....
Mouse  1106 RKEKSSTVLTGLRPGVEYTVQVWAQKGARESKKAKTKAPTEIDSPKNLVTNRVTENTATISWDPV 1170

  Fly  2044 AAGIGAATL---NDDGTLSNAETLLSSNARFQAISAIAVAQDGVINV-ADQGS-----LHVLALE 2099
            .|.|....:   :.||  ...|..:|.:.....::.:....:..|:| |.:|:     ....||.
Mouse  1171 RANIDRYMVRYTSADG--ETKEIPVSKDQSSTILTGLKPGMEYTIHVWAQKGARESKKADTKALT 1233

  Fly  2100 HYLPSHD-------ENGEFHIPFPPSSEI--YVFNRYGQHVATK--DLTSGKTRYSFLYSKNTSF 2153
            ...|..:       .:|......|||::|  |:......:...|  :|..|:.|:.....:....
Mouse  1234 EIDPPRNLRPFGVTHSGGVLTWLPPSAQIDGYILTYQFPNGTVKEVELPRGQQRFELQDLEQGVT 1298

  Fly  2154 GRLSTVTDASGNKIQFLRDYSNVVSSIENTQDHK---SEIQIN-----GIGIMTKLSEKGR-QEI 2209
            ..:|.|. ..||  |..|..|..:|:::....|.   |::|.|     |:..:....:..| .::
Mouse  1299 YPVSLVA-FKGN--QRSRTVSTTLSTVDARFPHPSDCSQVQQNTNAASGLYTIYLNGDASRPMQV 1360

  Fly  2210 ELDYDSNTG---LLNSRSSGGETYIYQYDEFGR----VTGMILPSGEI----------------- 2250
            ..|.|::.|   :...|::|      |.|.|.|    |.|...|..|.                 
Mouse  1361 YCDMDTDGGGWIVFQRRNTG------QLDFFKRWRSYVEGFGDPMKEFWLGLDKLHNLTTGTTTR 1419

  Fly  2251 --VRITSQLADSQGLTVYVHASVESLFSRERIAGEANELLVLGGVRSTFLKRGQAHADAELKANN 2313
              ||...|..:.....||....|.|  |:||..      |.:|..|.|              |.:
Mouse  1420 YEVRADLQTFNESAYAVYDFFQVAS--SKERYK------LSVGKYRGT--------------AGD 1462

  Fly  2314 TLVIHG---------DNGVVVEASAVARHPLLEAALPVEAEMLAMWSHQSVTMGEGLTNSMYSVY 2369
            .|..|.         ||.:.:...|:..|              ..|.:::..:..  .|..|   
Mouse  1463 ALTYHNGWKFTTFDRDNDIALSNCALTHH--------------GGWWYKNCHLAN--PNGKY--- 1508

  Fly  2370 SLVGDVRNPQQTLNREIWVNQS----------RVIGVEFDQFTNRE 2405
               |:.:: .:.:|.|.|....          |..|...|:|:.|:
Mouse  1509 ---GETKH-SEGVNWEPWKGHEFSIPYVELKIRPFGYSRDRFSGRK 1550

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ten-aNP_001162732.2 EGF_2 934..960 CDD:285248
Keratin_B2 998..1162 CDD:279797 51/161 (32%)
EGF_2 <1003..1025 CDD:285248 10/23 (43%)
EGF_2 1032..1057 CDD:285248 6/24 (25%)
EGF_2 <1071..1095 CDD:285248 6/23 (26%)
EGF_2 1101..1126 CDD:285248 9/24 (38%)
EGF_2 <1135..1157 CDD:285248 9/21 (43%)
EGF_CA 1163..1192 CDD:238011 5/43 (12%)
NHL 1622..1927 CDD:302697 71/386 (18%)
NHL repeat 1675..1721 CDD:271320 11/60 (18%)
NHL repeat 1745..1787 CDD:271320 6/45 (13%)
NHL repeat 1802..1847 CDD:271320 12/83 (14%)
NHL repeat 1864..1897 CDD:271320 9/32 (28%)
RHS_repeat 2213..2250 CDD:283287 11/43 (26%)
RhsA 2397..2958 CDD:225750 3/9 (33%)
Rhs_assc_core 2939..3015 CDD:274730
Tox-GHH 3274..3349 CDD:292269
TnnNP_808507.2 EGF_2 <142..166 CDD:285248 10/23 (43%)
EGF_2 169..197 CDD:285248 13/66 (20%)
EB 181..233 CDD:279949 22/89 (25%)
EGF_2 233..259 CDD:285248 11/30 (37%)
fn3 264..332 CDD:278470 10/80 (13%)
fn3 359..434 CDD:278470 14/79 (18%)
fn3 444..521 CDD:278470 16/84 (19%)
FN3 532..608 CDD:214495 16/101 (16%)
FN3 620..696 CDD:214495 17/96 (18%)
fn3 708..785 CDD:278470 15/86 (17%)
fn3 796..875 CDD:278470 19/115 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 868..888 6/24 (25%)
fn3 884..961 CDD:278470 13/76 (17%)
fn3 972..1049 CDD:278470 19/89 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1044..1063 5/21 (24%)
FN3 1060..1136 CDD:214495 10/76 (13%)
fn3 1148..1225 CDD:278470 14/78 (18%)
fn3 1236..1313 CDD:278470 16/79 (20%)
FReD 1327..1539 CDD:238040 48/262 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1225
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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