DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ten-a and shf

DIOPT Version :9

Sequence 1:	NP_001162732.2	Gene:	Ten-a / 32183	FlyBaseID:	FBgn0267001	Length:	3387	Species:	Drosophila melanogaster
Sequence 2:	NP_001284963.1	Gene:	shf / 31617	FlyBaseID:	FBgn0003390	Length:	460	Species:	Drosophila melanogaster

Alignment Length:	606	Identity:	133/606 - (21%)
Similarity:	200/606 - (33%)	Gaps:	186/606 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   540 CLSIALIFVSVVLTAMLAYFAAVSSMKPNMDSTNCILVQDVKSQPHDLRGGLAKSNEKGVATAFP 604
            ||...|..|.:|.|.:                  ||...:.:.|.|:..    .:|....|.:..
  Fly     8 CLVKWLYLVLIVHTLL------------------CIGQLECRQQHHNRN----NNNNNRRADSSS 50

  Fly   605 TEESIQTSTSDHGQNGHGLMNPSAGSGGSNSGIQQQLLLQQQQPHSINQPLTPLDATNTHLQDHH 669
            :||.       ||....||.| .|....|..|            |. :||        ...|...
  Fly    51 SEEG-------HGNTSDGLDN-FADQDASFVG------------HG-HQP--------RRGQRKK 86

  Fly   670 QLTYGGALPGGVGGIGMSGGGIMNGGLNGGLGGQLMQQPGGGLNG-HHHQALQPQLGGVVELKEF 733
            |...||...||.||.|..||...|.....|:...:.:|....|.. :..|....:|..:...:..
  Fly    87 QQGGGGGGSGGGGGNGGGGGSRHNRNEESGISLWINEQQLKMLTALYFPQGYSERLYAIHNSRVT 151

  Fly   734 NEAYHATIPAYQFWTLEFRNKHPAFIRF-NFTLPWG--AHFAVYSR-RNVAPSVTQHDFVEFIKG 794
            |:....|:  |.|..:      |:.:.: |||...|  .:|..:.| :.:..|:.:...:...|.
  Fly   152 NDLRDTTL--YNFLVI------PSEVNYVNFTWKSGRRKYFYDFDRLQTMDESILKAPTLSIRKS 208

  Fly   795 GRLDSHLRHRRSSANATTTGQDMELYRQDKDQSAESAQDQDSEQDESRSFDSSESYDVETPLDTA 859
            ||:..  ..:..|.....||..                            ..:.|::|...:.|
  Fly   209 GRIPQ--EQKNFSIFLPCTGNS----------------------------SGTASFNVGLKIQT- 242

  Fly   860 KQHLQRI-GKPQSHWVNKRSAGDGLPALDVDAMTVNVSLLQYLDTGLWFISVYNDELVAHSVSLL 923
             :|.:.: |.|......|..|..|:  .|:||..         .|.|              .:|.
  Fly   243 -RHNKPLSGTPIRLNFKKECAHRGV--YDIDASN---------PTSL--------------TTLQ 281

  Fly   924 AEEAEGVSTTCPNDCSGRGSC---YLGKCDCIDGYQGVDCSKSVCPVLCSAHGH-YGGGVCHCEE 984
            |.:.|     |...|...|.|   ::  |.|..||.|..|..:.|...|...|: ....||.|.|
  Fly   282 APDPE-----CSLKCGKNGYCNEHHI--CKCNVGYTGQYCETAFCFPQCLNGGNCTAPSVCTCPE 339

  Fly   985 GWKGAECDIPVGECEVPNCSSHGRCIE-GECHCERGWKGPYCDQHDCLDPLCSGHGTCVAGQ-CY 1047
            |::|.:|:  .|.|: ..|.:.|:||: .:|.|.:|:.|..|:...|:.| |...|.|:... |.
  Fly   340 GYQGTQCE--GGICK-DKCLNGGKCIQKDKCQCSKGYYGLRCEYSKCVIP-CKNEGRCIGNNLCR 400

  Fly  1048 CKAGWQGEDCGTIDQQVYQCLPGCSEHGTYDLETGQ-----CVCERHWTGPDCSQAVCSLDCGRN 1107
            |..|.:|:.|                      |.|:     |.|                   ||
  Fly   401 CPNGLRGDHC----------------------EIGRKQRSICKC-------------------RN 424

  Fly  1108 GVCESGK-CRCNSGWTGNLCD 1127
            |.|.|.| |:|:.|:.|..|:
  Fly   425 GTCVSHKHCKCHPGFYGRHCN 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ten-a	NP_001162732.2	EGF_2	934..960	CDD:285248	9/28 (32%)
		Keratin_B2	998..1162	CDD:279797	35/138 (25%)
		EGF_2	<1003..1025	CDD:285248	8/22 (36%)
		EGF_2	1032..1057	CDD:285248	8/25 (32%)
		EGF_2	<1071..1095	CDD:285248	4/28 (14%)
		EGF_2	1101..1126	CDD:285248	10/25 (40%)
		EGF_2	<1135..1157	CDD:285248
		EGF_CA	1163..1192	CDD:238011
		NHL	1622..1927	CDD:302697
		NHL repeat	1675..1721	CDD:271320
		NHL repeat	1745..1787	CDD:271320
		NHL repeat	1802..1847	CDD:271320
		NHL repeat	1864..1897	CDD:271320
		RHS_repeat	2213..2250	CDD:283287
		RhsA	2397..2958	CDD:225750
		Rhs_assc_core	2939..3015	CDD:274730
		Tox-GHH	3274..3349	CDD:292269
shf	NP_001284963.1	WIF	137..258	CDD:280237	25/160 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1225
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900