Protein Alignment Ten-a and Tenm3

DIOPT Version :10

• Sequence 1: NP_001162732.2
• Gene: Ten-a / 32183
• FlyBaseID: FBgn0267001
• Length: 3387
• Species: Drosophila melanogaster
• Sequence 2: XP_038950434.1
• Gene: Tenm3 / 306451
• RGDID: 1306641
• Length: 2721
• Species: Rattus norvegicus
• Alignment Length: 3232
• Identity: 904/3232 - (27%)
• Similarity: 1427/3232 - (44%)
• Gaps: 682/3232 - (21%)

  Fly   245 STAASSSIRSSHRNRNAL---NRLSGMTSSSSDSQTHHHQQQQQQQQQQQQQQQQQQLQISQQQQ 306
            |.::|.::::...:.:.|   ||:..:....:|           :..:|.|....:||.:.:...
  Rat    40 SYSSSETLKAFDHDSSRLLYGNRVKDLVHREAD-----------EYPRQGQNFTLRQLGVCESAT 93

  Fly   307 QQIAAVKQQQQMLPPEDSGDDDFVLGLGSLELG-NCSSGGESEEPPPEPAPPEIPPRT------- 363
            ::..|                 |...:|....| :.|:|.:::........||...|.
  Rat    94 RRGVA-----------------FCAEMGLPHRGYSISAGSDADTENEAVMSPEHAMRLWGRGVKS 141

  Fly   364 -QSLLMSLRKHSDYKL---KYEEKGDQKHEEFIPTSQLQKDYILSDNLRSDQQLKPISPGDSNGL 424
             :|..:|.|.:|...|   ::|.:.|.:.|:  |.           |.:....|:|:.|....
  Rat   142 GRSSCLSSRSNSALTLTDTEHENRSDSESEQ--PA-----------NNQGQPTLQPLPPSHKQ-- 191

  Fly   425 GGHPQQMPQSMSTGSNTIGHGGIDRGG------VGLPMGAGTMPGGVGGGPGGVAGGGP------ 477
              ||...|...|...|::    .:|..      ..||....|.|..|......|.|...
  Rat   192 --HPAHHPSVTSLNRNSL----TNRRNQSPAPPAALPAELQTTPESVQLQDSWVLGSNVPLESRH 250

  Fly   478 ---QVGVGPPGSGNGGNCQISGSQPL---VMPGFPLRNSHSAHAPHYSP-----YSPSRFHIDKR 531
               :.|              :|:.||   ..||:.:. |.|.::|...|     .|.|.|...|.
  Rat   251 FLFKTG--------------TGTTPLFSTATPGYTMA-SGSVYSPPTRPLPRNTLSRSAFKFKKS 300

  Fly   532 CQHRCSWKCLSIALIFVSVVLTAMLAYFAAVSSMKPNMDSTNCILVQDVKSQPHDLRGGLAKSNE 596
            .:: |||:|.::..:.|||:|..:|:||.|:.
  Rat   301 SRY-CSWRCTALCAVGVSVLLAILLSYFIAMH--------------------------------- 331

  Fly   597 KGVATAFPTEESIQTSTSDHGQNGHGLMNPSAGSGGSNSGIQQQLLLQQQQPHSINQPLTPLDAT 661
                 .|.....:|.:.:|..:||                             .:|....|
  Rat   332 -----LFGLNWHLQQTENDTFENG-----------------------------KVNSDTVP---- 358

  Fly   662 NTHLQDHHQLTYGGALPGG----VGGIGMSGGGIMNGGLNGGLGGQLMQQPGGGLNGHHHQALQP 722
                      |:..:||.|    :||.......|.:|.|:  :|.:.:|:
  Rat   359 ----------THTVSLPSGDNGKLGGFTHENNTIDSGELD--IGRRAIQE--------------- 396

  Fly   723 QLGGVVELKEFNEAYHATIPAYQFWTLEFRNKHPAFIRFNFTLPWGAHFAVYSRRNVAPSVTQHD 787
                              :|...||..:.....|.|::||.:|...|...||.|:.:.||.||:|
  Rat   397 ------------------VPPGIFWRSQLFIDQPQFLKFNISLQKDALIGVYGRKGLPPSHTQYD 443

  Fly   788 FVEFIKGGRLDSHLRHRRSSANATTTGQDMELYRQDKDQSAESAQDQDSEQDESRSFDSSESYDV 852
            |||.:.|.||.:.                                       |.|:...||
  Rat   444 FVELLDGSRLIAR---------------------------------------EQRNLVDSE---- 465

  Fly   853 ETPLDTAKQHLQRIGKPQSHWVNKRSAGDGLPALDVDAMTVNVSLLQYLDTGLWFISVYNDELVA 917
                        |.|: |:..|:...||                .:||||:|:|.::.|||....
  Rat   466 ------------RAGR-QARSVSLHEAG----------------FIQYLDSGIWHLAFYNDGKNP 501

  Fly   918 HSVSLLAEEAEGVSTTCPNDCSGRGSCYLGKCDCIDGYQGVDCSKSVCPVLCSAHGHYGGGVCHC 982
            ..||......|.| ..||.:|.|.|.|..|.|.|..|:.|.|||::.||||||.:|.|..|.|.|
  Rat   502 EQVSFNTIVIESV-VECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLC 565

  Fly   983 EEGWKGAECDIPVGECEVPNCSSHGRCIEGECHCERGWKGPYCDQHDCLDPLCSGHGTCVAGQCY 1047
            ..||||.|||:|..:|..|.|...|.||.|.|.|..|:||..|::.|||||.||.||.|:.|:|:
  Rat   566 FSGWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGENCEEADCLDPGCSNHGVCIHGECH 630

  Fly  1048 CKAGWQGEDCGTIDQQVYQCLPGCSEHGTYDLETGQCVCERHWTGPDCSQAVCSLDCGRNGVCES 1112
            |..||.|.:|..:..   .|...||.||||..|:|.|.|:.:|||||||..:||:|||.:|||..
  Rat   631 CNPGWGGGNCEILKT---MCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMG 692

  Fly  1113 GKCRCNSGWTGNLCDQLPCDSRCSEHGQCKNGTCVCSQGWNGRHCTL----------------PG 1161
            |.|||..||||..|:|..|..||:|||.||:|.|.|||||||.|||:                .|
  Rat   693 GTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTIAHYLDKIVKADKIGYKEG 757

  Fly  1162 CENGCSRHGQCTLENGEYRCDCIEGWAGRDCSIALELNCKDNIDNDGDGMTDCSDSECCSHPACS 1226
            |...|:.:|:|||:...:.|.|..||.|..|.:|:|..|.|:.||:|||:.||.|.:||...:|.
  Rat   758 CPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLVDCMDPDCCLQSSCQ 822

  Fly  1227 EHIMCLSSNDPVEVLLRK-QPPSVTA--SFYQRVKFLIEENSVQSYAHMDEYSENLFWSSFTPCR 1288
            ....|....||.:|:.:. |.||..|  |||.|:.|||..:|.........::::|
  Rat   823 NQPYCRGLPDPQDVISQSLQTPSQQAAKSFYDRISFLIGSDSTHVLPGESPFNKSL--------- 878

  Fly  1289 VSVMRGQVITPQGLGIVGIRVSVDRDSRFGFTLTRQGGWFDVLVNGGGAVTLQFQRSPFRPLTRT 1353
            .||:||||:|..|..::|:.||....|.:|:|:|||.|.||::.|||.::||.|:||||.....|
  Rat   879 ASVIRGQVLTADGTPLIGVNVSFLHYSEYGYTITRQDGMFDLVANGGASLTLVFERSPFLTQHHT 943

  Fly  1354 VFVPWNRIVVLPPVQMQLSDDDETT---SRNIKVAPL---NPALTFLNSIHYHTADEANDASKVC 1412
            |::|||...|:..:.|:..::|..:   |..::.:|:   :|..||..|
  Rat   944 VWIPWNVFYVMDTLVMKKEENDIPSCDLSGFVRPSPVIVSSPLSTFFRS---------------- 992

  Fly  1413 MDHDHEKLRPQLISTWMPNGVGAMPGKRVIFAETQIVQESIQIPGSDLHLTYQSSQASGYLSIVR 1477
                                   .|....|..|||::.|...|||:||.|:|.||:|:||.|:::
  Rat   993 -----------------------SPEDSPIIPETQVLHEETTIPGTDLKLSYLSSRAAGYKSVLK 1034

  Fly  1478 MRLTGETIPPTLTHVHVGVEIEGALHVKTYEADPSLVHTFAWNKRNVYRQKVYGVTVARISVGYQ 1542
            :.:|..|||..|..||:.|.:.|.|..|.:.|.|:|.:||.|:|.:.|.|||||::.|.:||||:
  Rat  1035 VTMTQATIPFNLMKVHLMVAVVGRLFQKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVVSVGYE 1099

  Fly  1543 HSTC-QSPVWIAQTAKLQGYDVDISDIGGWGLDIHHHYNFHEGILQKGDGSTLHMKEYPRTVKVV 1606
            :.:| ...:|..:||.||||::|.|::|||.||.||..:...|||.||:|....:.:.|..|..:
  Rat  1100 YESCLDLTLWEKRTAILQGYELDASNMGGWTLDKHHVLDVQNGILYKGNGENQFISQQPPVVSSI 1164

  Fly  1607 MGTGLQRPLTCPDYCNGVAKDAKLLTPIALATGPDGSLYVGDFNLVRRITPDGKVYTILQL---- 1667
            ||.|.:|.::||. |||.|...|||.|:|||.|.||||||||||.||||.|.|.|.::|:|
  Rat  1165 MGNGRRRSISCPS-CNGQADGNKLLAPVALACGIDGSLYVGDFNYVRRIFPSGNVTSVLELRNKD 1228

  Fly  1668 --SATQVSYQYYLAVSPADGHLYISDPERHQILRLVRLEKVKDPSINSDPVVGSGQRCIPGDEGN 1730
              .::..:::||||..|..|.||:||....:|.|...|...||.:.|::.|.|:|::|:|.||..
  Rat  1229 FRHSSNPAHRYYLATDPVTGDLYVSDTNTRRIYRPKSLTGAKDLTKNAEVVAGTGEQCLPFDEAR 1293

  Fly  1731 CGDGGPALLARLSHPKGLAIAADRTMYIADGTNIRAVDPKGVIHTLIGHHGHHNHWSPAPCSGTL 1795
            |||||.|:.|.|..|||:||..:..:|..|||.||.||..|:|.||:|.:...:. .|..|..::
  Rat  1294 CGDGGKAVEATLMSPKGMAIDKNGLIYFVDGTMIRKVDQNGIISTLLGSNDLTSA-RPLTCDTSM 1357

  Fly  1796 MANQAQLQWPTGLALSPLDGSLHFIDDRLVLRLTSDMKIRVVAGTPLHCSNGGQDGRVNKTGADN 1860
            ..:|.:|:|||.||::|:|.|::.:|:.:||::|.:.::|:.||.|:||...|.:..|.|.....
  Rat  1358 HISQVRLEWPTDLAINPMDNSIYVLDNNVVLQITENRQVRIAAGRPMHCQVPGVEYPVGKHAVQT 1422

  Fly  1861 VLGTVLAMAFSPFGNLYIADSDSRRVNSIRVVDTAGNMRYFAGKQEGTGSQTCDCAIGGGSNGSA 1925
            .|.:..|:|.|..|.|||.::|.:::|.||.|.|.|.:...||.     ...|||
  Rat  1423 TLESATAIAVSYSGVLYITETDEKKINRIRQVTTDGEISLVAGI-----PSECDC---------- 1472

  Fly  1926 TNSGVGGAGGSAYSTTVNPTRPNGGTTPTTPSGGNGNGNGNGSSATSSGGSVGGSNGSGGGANGG 1990
                                                                         .|..
  Rat  1473 -------------------------------------------------------------KNDA 1476

  Fly  1991 ACICAGGIALSTGTGSSSGSNGGGTLASIVGSGGLMSTGPTTTTTVLLGAKTTAAGIGAATLNDD 2055
            .|.|     ..||.|
  Rat  1477 NCDC-----YQTGDG-------------------------------------------------- 1486

  Fly  2056 GTLSNAETLLSSNARFQAISAIAVAQDGVINVADQGSLHVLALEHYLPSHDENGEFHIPFPPSSE 2120
                     .:.:|:..|.|::|.:.||.:.:||.|::.:.|:....|..:....:.:..|...|
  Rat  1487 ---------YAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQE 1542

  Fly  2121 IYVFNRYGQHVATKDLTSGKTRYSFLYSKNTSFGRLSTVTDASGNKIQFLRDYSNVVSSIENTQD 2185
            :|:|:..|.|..|..|.:|...|:|.||.:..   ::.|||::||.::..||.:.:...:.:..:
  Rat  1543 LYIFDINGTHQYTVSLVTGDYLYNFSYSNDND---VTAVTDSNGNTLRIRRDPNRMPVRVVSPDN 1604

  Fly  2186 HKSEIQINGIGIMTKLSEKGRQEIELDYDSNTGLLNSRS-SGGETYIYQYDEFGRVTGMILPSGE 2249
            ....:.|...|.:..::.:|.:.:...|..|:|||.::| ..|.|..:.||..||:|.:..|:|.
  Rat  1605 QVIWLTIGTNGCLKSMTAQGLELVLFTYHGNSGLLATKSDETGWTTFFDYDSEGRLTNVTFPTGV 1669

  Fly  2250 IVRITSQLADSQGLTVYVHASVESLFSRERIAGEANEL--------LVLGGVRSTFLKRGQAHAD 2306
            :..:...:  .:.:||.:.:|     |||......:.|        :|...:|:::    |...|
  Rat  1670 VTNLHGDM--DKAITVDIESS-----SREEDVSITSNLSSIDSFYTMVQDQLRNSY----QIGYD 1723

  Fly  2307 AELKANNTLVIHGDNGVVVEASAVARHPLLEAALPVEAEMLAMWSHQSVTM---------GEGLT 2362
            ..|:             :..||.:..|      ...|..:||..::.:|..         |:.|.
  Rat  1724 GSLR-------------IFYASGLDSH------YQTEPHVLAGTANPTVAKRNMTLPGENGQNLV 1769

  Fly  2363 NSMYSVYSLVGDVRNPQQTLNREIWVNQSRVIGVEFDQFTNRETFYDARRTPILIVAYDQSGLPK 2427
            ...:......|.|    ....|::.||...::.|:||:.|..|..||..|..:|.:|||.||.|.
  Rat  1770 EWRFRKEQAQGKV----NVFGRKLRVNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPT 1830

  Fly  2428 SYYPTNG-YPVNITYDRFNRVEGWAWGPAELKYSYDRHG-LLSEITSQQDGIV-SFVYNDWNLVS 2489
            .:.|::. ..||:||....::.....|....|..||..| ::|.:.:  ||.. |:.|.:.::|
  Rat  1831 LWLPSSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDSQGRIVSRVFA--DGKTWSYTYLEKSMV- 1892

  Fly  2490 EIGLASQRKFVLQYDDAGGLRHVVLPSGTRHSFSMQTSIGFIRCTYTPPGSTRAYLQHYSHAGAL 2554
             :.|.|||:::.:||....|..:.:||..||:.....|||:.|..|.||.|..:.:..|:..|.|
  Rat  1893 -LLLHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPESNASIITDYNEEGLL 1956

  Fly  2555 LQTILPGDGARIVYRYNAAGQLTEVVHGDGRSEFQYNEATGMPSTVSHTER----ELEYRWDFEY 2615
            |||...|...|::::|....:|:|:::...|..|.|:|..|:..||:....    .:.||
  Rat  1957 LQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFICTIRYR----- 2016

  Fly  2616 AAGLLAEERIDYVAKTGLSNAKFSYEYDSQLRVVALQGRIGGQSLPTQAFAYDPRTGRPSLIGQF 2680
            ..|.|.:.:|...::.|:.||:|.|.||:..||.::||.|....||...:.:|..:|:....|:|
  Rat  2017 QIGPLIDRQIFRFSEDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKF 2081

  Fly  2681 RFSQPAQNQTQLHDGTASFTRTVDGRFQTQRMALAIHRLEVFRMEFSYGVHGRISQTRTYTRNMA 2745
            .......||. :.....::|:..|...:.:.:...|.|..::.:...|...||:::     |.:.
  Rat  2082 GVIYYDINQI-ISTAVMTYTKHFDAHGRIKEIQYEIFRSLMYWITIQYDNMGRVTK-----REIK 2140

  Fly  2746 VNSYTNVKNYT--WDCDGQLVGVEAQEP--WGFRYDDNGN--LLSLTYRGNTIPMEYNAQDRIVK 2804
            :..:.|...|.  :|.||||..|...|.  |.:.||.|||  ||:.:......|:.|:.:|||.:
  Rat  2141 IGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSSSARLTPLRYDLRDRITR 2205

  Fly  2805 FGEGQYKYDARGLVAQNAREERFHYNTQGLLVRA-SKRGRFDVRYYYDHLKRLTTRKDNFGNVTQ 2868
            .|:.||:.|..|.:.|.. .|.|.|:::|||.|. ||...:.|.|.||.|.|..:.|.:.|...|
  Rat  2206 LGDVQYRLDEDGFLRQRG-TEIFEYSSKGLLTRVYSKGSGWTVIYRYDGLGRRVSSKTSLGQHLQ 2269

  Fly  2869 FFYTNQQRPYEVSQIYSPRDGKLMSLTYDDVGHLIYAQVYR-HKYYVATDQSGTPLMLFNQYGEG 2932
            |||.:...|..::.:|:....::.||.||..|||...::.. .::|:|:|.:||||.:|:..|..
  Rat  2270 FFYADLTYPTRITHVYNHSSSEITSLYYDLQGHLFAMEISSGDEFYIASDNTGTPLAVFSSNGLM 2334

  Fly  2933 IREIMRSPFGHIVYDSNPYLYLPIDFCGGILDQVTTLVHMGDGRVYDPLIGQWMSPD---WQRVA 2994
            :::|..:.:|.|.:|||....|.|.|.||:.|.:|.|:|.|: |.||.|.|:|.:||   |:|:.
  Rat  2335 LKQIQYTAYGEIYFDSNIDFQLVIGFHGGLYDPLTKLIHFGE-RDYDILAGRWTTPDIEIWKRIG 2398

  Fly  2995 ERIITPTRLHLYRFNGNDPINVGHE-RHYPEDFAAWMRTLGYNVGNLVPQL---ARDLWQPPALW 3055
            :   .|...:||.|..|:|.:..|: :.|..|..:|:.|.|:::.|.:|..   ..||.:|
  Rat  2399 K---DPAPFNLYMFRNNNPASKIHDVKDYITDVNSWLVTFGFHLHNAIPGFPVPKFDLTEP---- 2456

  Fly  3056 GRPPANPVALNLRRPFDNIPTM-----AVESGFLAHLNVRRMSDFEQLSAPPRSALKCDVMDPSP 3115
                  ...|...:.::::|.:     .|.....|.|::.:|::. |:|.......:..:...:.
  Rat  2457 ------SYELVKSQQWEDVPPIFGVQQQVARQAKAFLSLGKMAEV-QVSRRKAGGEQSWLWFATV 2514

  Fly  3116 KTIGSDTEPPFGKGIVVSRTADGQAIVSSVPAANAIYRDVYTSVFNRSKLLPFTFVVHNAQQDSF 3180
            |::       .|||:::: .:.|:...:.:..||.....|...:.|...|....|.:..  :|:.
  Rat  2515 KSL-------IGKGVMLA-VSQGRVQTNVLNIANEDCIKVAAVLNNAFYLENLHFTIEG--KDTH 2569

  Fly  3181 FFVKE-------DAWRATEDRQQLKRLQGQVNTTFHEITREATVGSGPAGAANGGAGSSSSSSSS 3238
            :|:|.       ...|.|..|   |.|:..:|.|   :::..||.:|
  Rat  2570 YFIKTTTPESDLGTLRLTSGR---KALENGINVT---VSQSTTVVNG------------------ 2610

  Fly  3239 SGGGSSSNTGNYLDVKIHGAHAIINLRYGTTVAKEQQRLMHHAKLTAVRKAWHREKEALRSGLTT 3303
                   .|..:.||::......:::|||.|:.:|:.|::..|:..|:.:||.||::.:|.|...
  Rat  2611 -------RTRRFADVEMQFGALALHVRYGMTLDEEKARILEQARQRALARAWAREQQRVRDGEEG 2668

  Fly  3304 ALEWSQQETDEILKQSYANNYEGEYIHDVNLYPELAEDPYNIKFVKK 3350
            |..|::.|..::|.......|:|.|:..|..|||||:...||:|:::
  Rat  2669 ARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLRQ 2715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ten-a	NP_001162732.2	acid_disulf_rpt	1199..1225	CDD:411265	12/25 (48%)
		NHL	1622..1927	CDD:302697	124/310 (40%)
		NHL repeat	1675..1721	CDD:271320	18/45 (40%)
		NHL repeat	1745..1787	CDD:271320	18/41 (44%)
		NHL repeat	1802..1847	CDD:271320	19/44 (43%)
		NHL repeat	1864..1897	CDD:271320	13/32 (41%)
		RHS_core	<2118..>2248	CDD:469161	36/130 (28%)
		RhsA	<2366..3015	CDD:442442	205/666 (31%)
		Tox-GHH	3272..3349	CDD:464783	26/76 (34%)
		EGF_2	937..960	CDD:400365	9/22 (41%)
		EGF_2	1003..1025	CDD:400365	10/21 (48%)
		EGF_2	1034..1057	CDD:400365	11/22 (50%)
		C_rich_MXAN6577	<1035..1146	CDD:469225	57/110 (52%)
		EGF_CA	1163..1192	CDD:238011	10/28 (36%)
Tenm3	XP_038950434.1	Ten_N	11..307	CDD:461932	61/331 (18%)
		DUF5885	521..675	CDD:437064	76/156 (49%)
		C_rich_MXAN6577	<680..782	CDD:469225	47/101 (47%)
		DSL	697..740	CDD:473190	27/42 (64%)
		acid_disulf_rpt	791..821	CDD:411265	14/29 (48%)
		NHL	1161..1520	CDD:302697	147/500 (29%)
		NHL repeat	1190..1229	CDD:271320	24/38 (63%)
		NHL repeat	1241..1284	CDD:271320	16/42 (38%)
		NHL repeat	1308..1342	CDD:271320	17/33 (52%)
		NHL repeat	1364..1403	CDD:271320	16/38 (42%)
		NHL repeat	1426..1459	CDD:271320	13/32 (41%)
		RhsA	1474..2414	CDD:442442	280/1060 (26%)
		NHL repeat	1494..1520	CDD:271320	8/25 (32%)
		Tox-GHH	2637..2714	CDD:464783	26/76 (34%)