DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ten-a and tnn

DIOPT Version :9

Sequence 1:	NP_001162732.2	Gene:	Ten-a / 32183	FlyBaseID:	FBgn0267001	Length:	3387	Species:	Drosophila melanogaster
Sequence 2:	XP_005171321.1	Gene:	tnn / 30234	ZFINID:	ZDB-GENE-990415-262	Length:	1020	Species:	Danio rerio

Alignment Length:	793	Identity:	177/793 - (22%)
Similarity:	265/793 - (33%)	Gaps:	275/793 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1053 QGEDCGTIDQQVY-------------------QCLPG-----------CSEHGTYDLETGQCVCE 1087
            |...||..|.:.:                   ||..|           ||.||||..::..|.|.
Zfish    86 QPAGCGCADSEDFKALLYRVNGLEEEVNYLKSQCAQGCCKGGAGVDTSCSGHGTYQQDSCSCKCN 150

  Fly  1088 RHWTGPDCSQAVCSLDCGRNGVCESGKCRCNSGWTGNLCDQLPCDSRCSEHGQCKNGTCVCSQGW 1152
            ..|.|||||.:.|..:|..||.|..|:|.|..|:||:.|.||.|.:.|.:.|.|.:|.|||..|:
Zfish   151 PGWEGPDCSISSCPDECNDNGRCVDGRCVCYEGYTGHDCSQLTCPNDCKDKGHCVDGKCVCFSGF 215

  Fly  1153 NGRHCTLPGCENGCSRHGQCTLENGEYRCDCIEGWAGRDCSIALELNCKDNIDNDGDGMTDCSDS 1217
            :|..|::..|.|.|..:|:|.    :.:|.|.||:.|.|||:.|.
Zfish   216 SGEDCSIATCPNDCIGNGRCV----DGQCICDEGFFGIDCSMVLG-------------------- 256

  Fly  1218 ECCSHPACSEHIMCLSSNDPVEVLLRKQPPSVTASFYQ-----------RVKFLIEENSVQSYAH 1271
                    .:.:..:...| |.:|:..:  ||..:.|.           .:|.:..||:..||..
Zfish   257 --------PKGLRLIKVTD-VSLLVEWE--SVRGAEYYILSYHPKGNKGAIKEVQVENTKNSYLI 310

  Fly  1272 MD-----EYSENLFWSSFTPCRVSVMRG------QV-ITPQGLGIVGIRV------SVDRDSRFG 1318
            ..     .|...::         :|:||      |: .|.:..||.||:|      |:..|.:..
Zfish   311 TGLKPGVTYIVQVY---------AVIRGINSESDQITATTEVSGIEGIKVLSQTEDSIQVDWKNP 366

  Fly  1319 ------FTLTR-----QGGWFDVL-------------VNGGGAVTLQFQR--------------- 1344
                  |.||.     |||..:|:             :|.|....:..|.
Zfish   367 GIIVDYFKLTHASHDGQGGHENVVMSQEARTKHTIVGLNPGTEYQIGVQAIKGENEGKASFATGV 431

  Fly  1345 ----SPFRPLTRTV-----FVPWNRIVVLPPVQMQLSDDDETTSRNIKVAPLNPALTFLNSIHYH 1400
                :|....||.|     .|.|:.:.......|......|.|||.||||
Zfish   432 TDIDAPTNLATREVTENSATVTWDGVRAEIDGYMLTYSSAEGTSREIKVA--------------- 481

  Fly  1401 TADEANDASKVCMDHDHEKLRPQLIST---WMPNGVGAMPGKRVIFAET-----------QIVQE 1451
                |...|     :....|:|.::.|   |...| .....|.:..|||           ::.::
Zfish   482 ----AGATS-----YQLTSLKPGVLYTVFLWAYKG-SRSSRKSMTEAETDIDAPTNLMTREVTED 536

  Fly  1452 SIQIPGSDLH-------LTYQSSQASGYLSIVRM-------RLTGETIPPTLTHVHVGVEIEGAL 1502
            |..:..:.:.       |.|.|...||  ..||:       |.|| ..|..|..|:|.. |:||.
Zfish   537 SASVTWNKVQADIDGYMLKYSSLDGSG--QEVRVGADSTSYRFTG-LKPGVLYTVYVWA-IKGAR 597

  Fly  1503 HVK--TYEADPSLVHTFAWNKRNVYRQKVYGVTVARISVGYQHSTCQSPVWIAQTAKLQGYDVDI 1565
            ..|  :.||:..:.     ...|:..|:   ||....||          .|....|.:.||.:..
Zfish   598 SSKKSSTEAETDID-----APTNLLTQE---VTEDSASV----------TWNKVQADIDGYMLKY 644

  Fly  1566 SDIGGWGLDIH-----HHYNF---HEGILQKGDGSTLHMKEYPRTVKVVMGTGLQRPLT------ 1616
            |.:.|.|.::.     ..|.|   ..|:|            |..:|..|.|:...|..|
Zfish   645 SSLDGSGQEVRVGADSISYRFTGLKPGVL------------YTVSVWAVKGSRSSRKATTEAETE 697

  Fly  1617 --CPDYCNGVAKDAKLLTPIALATGPDGSL--YVGDFNLVRRITPDGKVYTI----------LQL 1667
              .|.  |..|.|.:..|.......|..::  |:..:.     ..||.:.|:          ..|
Zfish   698 IDAPK--NLKATDVQTQTSTLTWKAPQANIEGYILTYR-----AEDGSMQTVEKTLTARENRFAL 755

  Fly  1668 SATQVSYQYYLAV 1680
            |..::..:|.:.:
Zfish   756 SGLEMGKKYIVTL 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ten-a	NP_001162732.2	EGF_2	934..960	CDD:285248
		Keratin_B2	998..1162	CDD:279797	46/138 (33%)
		EGF_2	<1003..1025	CDD:285248
		EGF_2	1032..1057	CDD:285248	1/3 (33%)
		EGF_2	<1071..1095	CDD:285248	11/23 (48%)
		EGF_2	1101..1126	CDD:285248	10/24 (42%)
		EGF_2	<1135..1157	CDD:285248	9/21 (43%)
		EGF_CA	1163..1192	CDD:238011	9/28 (32%)
		NHL	1622..1927	CDD:302697	12/71 (17%)
		NHL repeat	1675..1721	CDD:271320	1/6 (17%)
		NHL repeat	1745..1787	CDD:271320
		NHL repeat	1802..1847	CDD:271320
		NHL repeat	1864..1897	CDD:271320
		RHS_repeat	2213..2250	CDD:283287
		RhsA	2397..2958	CDD:225750
		Rhs_assc_core	2939..3015	CDD:274730
		Tox-GHH	3274..3349	CDD:292269
tnn	XP_005171321.1	EGF_alliinase	<133..163	CDD:282688	14/29 (48%)
		EGF_2	161..189	CDD:285248	11/27 (41%)
		EGF_2	193..220	CDD:285248	10/26 (38%)
		EGF_2	224..251	CDD:285248	10/30 (33%)
		fn3	257..333	CDD:278470	15/87 (17%)
		fn3	344..426	CDD:278470	17/81 (21%)
		fn3	435..514	CDD:278470	22/103 (21%)
		fn3	523..602	CDD:278470	19/82 (23%)
		fn3	611..683	CDD:278470	20/101 (20%)
		fn3	699..773	CDD:278470	13/77 (17%)
		FReD	792..1003	CDD:238040
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1225
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900