DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ten-a and tncb

DIOPT Version :9

Sequence 1:NP_001162732.2 Gene:Ten-a / 32183 FlyBaseID:FBgn0267001 Length:3387 Species:Drosophila melanogaster
Sequence 2:NP_001299845.1 Gene:tncb / 30037 ZFINID:ZDB-GENE-980526-104 Length:1811 Species:Danio rerio


Alignment Length:1627 Identity:358/1627 - (22%)
Similarity:559/1627 - (34%) Gaps:501/1627 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   932 TTCPNDCSGRGSCYLGKCDCIDGYQGVDCSKSVCPVLCSAHGHYGGGVCHCEEGWKGAECDIPVG 996
            :.||::|.|||.|...:|.|.:.:.|.|||:.:||..|...|....|.|:|:||:.|.:|    |
Zfish   254 SNCPSNCLGRGRCVDDECVCDEPWTGFDCSELICPNDCFDRGRCENGTCYCDEGFTGEDC----G 314

  Fly   997 ECEVP-NCSSHGRCIEGECHCERGWKGPYCDQHDCL----------------DP----------- 1033
            |...| ||:.||||:.|:|.|..|:.|..|.:..||                ||           
Zfish   315 ELTCPQNCNHHGRCVNGQCICNIGYSGEDCSKLTCLNDCSERGHCFNGKCICDPGFEGEDCSLLS 379

  Fly  1034 ---LCSGHGTCVAGQCYCKAGWQGEDCGTIDQQVYQCLPGCSEHGTYDLETGQCVCERHWTGPDC 1095
               .|:|.|.||.|:|.|..|::|:||..:     .||..|.:.|.  ...|:|:|:..:.|.||
Zfish   380 CPDNCNGRGHCVNGECICGPGYEGDDCSEL-----SCLNNCHDRGR--CVNGKCICKAGFAGEDC 437

  Fly  1096 SQAVCSLDCGRNGVCESGKCRCNSGWTGNLCDQLPCDSRCSEHGQCKNGTCVCSQGWNGRHCTLP 1160
            |...|..||...|.|..|||.|:.|:.|..|....|...|..||||.:|.|:|.:|:.|..|::.
Zfish   438 SIKTCPHDCHGRGECVDGKCVCHDGFAGEHCGIKTCPHHCHGHGQCVDGKCICHKGFAGEDCSIK 502

  Fly  1161 GCENGCSRHGQCTLENGEYRCDCIEGWAGRDCSIALELN-------CKDN--IDNDGDGMTDCS- 1215
            .|.|.|...|||.    :.:|.|.:|:||.||||....|       |.|.  |.:||....||: 
Zfish   503 TCPNHCHGQGQCI----DGKCICHDGFAGEDCSIKTCPNHCHGRGRCVDGKCICHDGFAGEDCNI 563

  Fly  1216 --------------DSECCSHPA-----CSEHIMCLSSNDPVEVLLRKQPPSVTASFYQRVKFLI 1261
                          |.:|..|..     ||| :.|  .||     ...:...|.......:.|..
Zfish   564 KTCPNDCHDHGECVDGKCICHAGFTGHDCSE-LTC--PND-----CHNRGRCVNGQCVCNIGFTG 620

  Fly  1262 EENSVQSYAH--MD----EYSENLFWSSFTPCRVSVM--------RGQVITPQGLGIVGIRVSVD 1312
            |:...::..:  :|    |..:.:.:..:|....||:        :||.:  .|:.|..:     
Zfish   621 EDCGTKTCPNNCLDRGFCEDGKCVCFEGYTGEDCSVLTCPADCNDQGQCL--NGMCICDL----- 678

  Fly  1313 RDSRFGFTLTRQGGWFDVLVNGGGAVTLQFQRSPFRPLT------RTVFVPW-NRIVV------- 1363
                 |||             |.....:    ||.|.||      .||.|.| |.::|       
Zfish   679 -----GFT-------------GDDCSEI----SPPRDLTVTEVDPETVDVAWVNEMLVTEYLITY 721

  Fly  1364 LP------PVQMQLSDDDETTSRNIKVAPLNPALTFLNSIHYHTADEANDASKVCMDHDHEKLRP 1422
            :|      .::|::|.:.:|.:    :..|.|.:.:|.|:.      |...||:.:.....    
Zfish   722 VPTAPGGLEMEMRVSGEKKTAT----IRELEPGIEYLISVF------AVLNSKMSVPVSAR---- 772

  Fly  1423 QLISTWMPNGVGAMPGKRVIFAETQIVQESIQIPGSDLHLTYQSS------------------QA 1469
              |:|.:|...| :..|.|.....::..:.:.||....:|.::::                  :.
Zfish   773 --IATHLPEPEG-LKFKSVKETSVEVEWDPLNIPFDGWNLIFRNTKEEDGEILNSLAPPETTFEQ 834

  Fly  1470 SGY---------LSIVRMRLTGETIPPTLTHVHVGVEIEGALHVKTYEADPSLVHTFAWNKRNVY 1525
            ||.         |.:|:....|   ||...:|...::....:.|:......:||         .:
Zfish   835 SGLGPGQEYEVKLEVVKNNTRG---PPASKNVVTMIDAPSQVDVRDVTDTTALV---------TW 887

  Fly  1526 RQKVYGVTVARISVGY------------QHSTCQSPVWIAQTAKLQGYDVDISDIGG-------- 1570
            .|.|  ..|..|||.|            :.|:.::...:|:.:....|:|.:....|        
Zfish   888 LQPV--AQVDGISVSYGPNTDSSDRNTIELSSIETQYHLAELSPDTEYEVSLMARRGEMSSFPIY 950

  Fly  1571 ----WGLDIHHHYNFHEGILQKGDGSTLHMKEYPRTV----------------KVVMGTGLQ--- 1612
                ..||...|.   :.|.|..:..||..:.....|                ::|..:|||   
Zfish   951 ETFTTDLDSPKHL---KAIEQTDESITLEWRNSRANVLNYRVKYGPLSGGEHGELVFPSGLQDTT 1012

  Fly  1613 -------RPLTCPDYCNGVA--KDAKLLTPIALAT-------GPDGSLYVGD-----FNLVRRIT 1656
                   ||.|  :|..||.  |:.:...|   ||       .|...|.|.:     ..||.| .
Zfish  1013 QAKITGLRPGT--EYGMGVTSIKEERESLP---ATTNAVTDLDPPKDLQVSETTETTLALVWR-R 1071

  Fly  1657 PDGKVYTILQLSATQVSYQYYLAVSPADG-----------HLYISDPERHQILRLVRL-----EK 1705
            |..|:.|            |.|...||||           :.||.......:|..:.|     .|
Zfish  1072 PVAKIDT------------YSLVFIPADGDKTELKIPGAANTYILTGLNPGMLHTITLTAERGRK 1124

  Fly  1706 VKDP---SINSD---PVVG----------SGQRCIPGDEGNCGDGGPALLARLSHPKGLAIAADR 1754
            :..|   |.::|   |.||          |.......|.|..    ...|..:|.|.||      
Zfish  1125 MSAPATLSASTDEEKPQVGNITISDVSWDSFSMSWDLDRGEV----EGFLIEVSDPDGL------ 1179

  Fly  1755 TMYIADGTNIRAVDPKGVIHTLIGHHGHHNHWSPAPCS-----------GTLM------------ 1796
                :||.|          |||.|..........:|.:           |.|:            
Zfish  1180 ----SDGQN----------HTLSGQEFSLAVTDLSPSTFYRVTLYGLYKGELLDPVFAEAITEAE 1230

  Fly  1797 ------------ANQAQLQWPT------GLALSPLD----GSLHFIDDRLVLRLTSDMKIRVVAG 1839
                        .:..::.|..      ..||..||    |..|.|.      ::.|.:...|.|
Zfish  1231 PEVEHITVSDITPHSFKVTWTAPEAVFDSFALKVLDSSGLGRPHQIS------VSGDKRTEAVTG 1289

  Fly  1840 TPLHCSNGGQDGRVNKTGADNVLGTVLAMAFSPFGNLYIADSDSRRVNSIR---VVDTAGNMRYF 1901
            .     |...|..:      .:.|.:|...|.|.  ..:|.:.......||   |.||:..:.:.
Zfish  1290 L-----NEDTDYEI------ELFGIILGRKFQPI--FTVARTGLGTPKGIRFSDVTDTSATVHWT 1341

  Fly  1902 AGKQEGTGSQTCDCAIGGGS------NGSATNSGVGG-AGGSAYSTTVNPTRPNGGTTPTTPSGG 1959
            .........:.....|.|||      :|..:.:.:.. ..|..|..||...:   |...:.|   
Zfish  1342 MPHTRVDNYRVIYVPIQGGSPLTLRVDGGESQAMLSNLTPGVTYQVTVIAVK---GLEESEP--- 1400

  Fly  1960 NGNGNGNGSSATSSGGSVGGSNGSGGGANGGACICAGGIALSTGTG---SSSGSNGGGTLASIVG 2021
               |:...::|......:...|.|...|     :.....:::|..|   :.|..:....:..:.|
Zfish  1401 ---GSERVTTALDKPRGLTAVNISDTEA-----LLLWQPSIATVDGYVITYSADSVAPVMERVSG 1457

  Fly  2022 SG---GLMSTGPTTTTTVLLGA-KTTAAGIGAATLNDDGTLSNA-ETLLSSNARFQA-------- 2073
            :.   .:.|..|.|..||.:.| :.||.  .|||..|..|..:| :.|.:||.:.:.        
Zfish  1458 NTVEFEMSSLTPATLYTVKVYAFRDTAK--SAATSTDFTTDVDAPQNLAASNIQTETAMLTWKPP 1520

  Fly  2074 ---ISAIAVAQDGVINVADQGSLHVLALEHYLPSHDENGEFHIPF-----PPSSEIY--VFNRYG 2128
               ||...::.:....|..:..|...|..:.:.....:.|:.:..     |..|.:.  ||...|
Zfish  1521 RADISGYILSFESADGVVKEVVLSPTATFYSMSQLTASTEYTVKLQAIAGPKRSRVISTVFLTIG 1585

  Fly  2129 ----------QHVATKDLTSGKTRYSFLYSKNTSFGRLST----VTDASG---------NKIQFL 2170
                      |.:...|.|||  .|: :|.:......|..    .||..|         .|::|.
Zfish  1586 VLYKHPKDCSQALLNGDTTSG--LYT-IYLRGDESQPLQVYCDMTTDGGGWIVFVRRQSGKVEFF 1647

  Fly  2171 RDYSNVVSSIENTQDHKSEIQINGIGIMTKLSEKGRQEIELDYDSNTGLLNSRSSGGETYIYQYD 2235
            |::.|..:...:..|   |..: |:..:.|::..|:.|:.:|.         |..|...|. |||
Zfish  1648 RNWKNYTAGFGDLND---EFWL-GLSNLHKITSFGQYELRVDL---------RDKGESAYA-QYD 1698

  Fly  2236 EF 2237
            :|
Zfish  1699 KF 1700

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ten-aNP_001162732.2 EGF_2 934..960 CDD:285248 10/25 (40%)
Keratin_B2 998..1162 CDD:279797 64/194 (33%)
EGF_2 <1003..1025 CDD:285248 10/21 (48%)
EGF_2 1032..1057 CDD:285248 12/38 (32%)
EGF_2 <1071..1095 CDD:285248 6/23 (26%)
EGF_2 1101..1126 CDD:285248 10/24 (42%)
EGF_2 <1135..1157 CDD:285248 10/21 (48%)
EGF_CA 1163..1192 CDD:238011 10/28 (36%)
NHL 1622..1927 CDD:302697 78/404 (19%)
NHL repeat 1675..1721 CDD:271320 18/77 (23%)
NHL repeat 1745..1787 CDD:271320 10/41 (24%)
NHL repeat 1802..1847 CDD:271320 11/54 (20%)
NHL repeat 1864..1897 CDD:271320 9/35 (26%)
RHS_repeat 2213..2250 CDD:283287 7/25 (28%)
RhsA 2397..2958 CDD:225750
Rhs_assc_core 2939..3015 CDD:274730
Tox-GHH 3274..3349 CDD:292269
tncbNP_001299845.1 DnaJ <471..>544 CDD:333066 28/76 (37%)
fn3 689..760 CDD:306538 19/80 (24%)
fn3 778..858 CDD:306538 12/83 (14%)
fn3 868..948 CDD:306538 15/90 (17%)
FN3 958..1047 CDD:238020 21/96 (22%)
fn3 1050..1128 CDD:306538 20/90 (22%)
fn3 1140..1215 CDD:306538 19/98 (19%)
fn3 1231..1303 CDD:306538 13/88 (15%)
fn3 1323..1400 CDD:306538 15/79 (19%)
fn3 1410..1482 CDD:306538 13/76 (17%)
fn3 1498..1570 CDD:306538 10/71 (14%)
FReD 1589..1798 CDD:238040 29/129 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1225
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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