|
Fly 75 HGMGHGYGSSSEDEYQNTGQATAFDTQLLAQLLLQSQQLASMEHYNSDCEPDYLRQRDRHHEEAT 139
|.|...|.|||::.........:|::: .::..||.:...:|..|..:..:
Rat 17 HEMDLAYTSSSDESEDGRKPRQSFNSR------------ETLHEYNQELRRNYNSQSRKRKD--- 66
Fly 140 PLGDGTPTVTAAAPEVTYAQPHQQRSTMPAGSPLKVSTVSAGKYQSNANLGLFPNSSSSGGSSVQ 204
|..:..|:.:.: |.| |:.:| ||::. :|.|..|..::
Rat 67 --------VEKSTQEIEFCE------TPP--------TLCSG-YQTDM------HSVSRHGYQLE 102
Fly 205 NGVTAHTPRSTNPFLNGSTKFASDDGGLENINMLKPSASSSTAASSSIRSSHRNRNALNRLSGMT 269
.|....| ..:|.....:.|:.......:..||..||..|
Rat 103 MGSDVDT---------------ETEGAASPDHALRMWIRGMKSEHSSCLSSRAN----------- 141
Fly 270 SSSSDSQTHHHQQQQQQQ---------QQQQQQQQQQQLQISQQQQQQIAAVKQQQQMLPPEDSG 325
|:.|.:.|.|.::...:. ..:......|.:|.|...|... :.|||....
Rat 142 SALSLTDTDHERKSDGENGFKFSPVCCDMEAPADSAQDMQSSPHNQFTF-------RPLPPPPPP 199
Fly 326 DDDFVLGLGSLELGNCSSGGESEEPP----------------PEPAPPEIPPRTQSLLMSLRKHS 374
.. .|:. :.:|| |.||.|..|..||
Rat 200 PH------------ACTC---ARKPPPTVDSLQRRSMTTRSQPSPAAPAPPTSTQ---------- 239
Fly 375 DYKLKYEEKGDQKHEEFIPTSQLQKDYILSDN--LRSDQQLKPISPGDSNGLGGHPQQMPQSMST 437
|..| |...::|:.| |.:...|.....|.|.......|..|.:
Rat 240 ----------DSVH--------LHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLT--- 283
Fly 438 GSNTIGHGGIDRGGVGLPMGAGTMPGGVGGGPGGVAGGGPQVGVGPPGSGNGGNCQISGSQPLVM 502
|||: ..|| |..:
Rat 284 -SNTV--------------------------------------YSPP--------------PRPL 295
Fly 503 PGFPLRNSHSAHAPHYS-PYSPSRFHIDKRCQHRCSWKCLSIALIFVSVVLTAMLAYFAAVSSMK 566
| |::.|..|..:: || || |:|||.:::...::|.|..:|||..||.
Rat 296 P----RSTFSRPAFTFNKPY---------RC---CNWKCTALSATAITVTLALLLAYVIAVH--- 341
Fly 567 PNMDSTNCILVQDVKSQPHDLRGGLAKSNEKGVATAFPTEESIQTSTSDHGQNGHGLMNPSAGSG 631
:.....:.|| :.:....|::...|..||:.|:.| |..|..
Rat 342 --------LFGLTWQLQP------VGQIYANGISNGNPGTESMDTTYS-----------PIGGKV 381
Fly 632 GSNSGIQQQLLLQQQQPHSINQPLTPLDATNTHLQDHHQLTYGGALPGGVGGIGMSGGGIMNGGL 696
...| .:.:.| .|..|..|.:
Rat 382 SDKS----------------EKKVFP-----------------------------KGRAIDTGEV 401
Fly 697 NGGLGGQLMQQPGGGLNGHHHQALQPQLGGVVELKEFNEAYHATIPAYQFWTLEFRNKHPAFIRF 761
: :|.|:|| |||...||..:....||.:::|
Rat 402 D--IGAQVMQ---------------------------------TIPPGLFWRFQITIHHPIYLKF 431
Fly 762 NFTLPWGAHFAVYSRRNVAPSVTQHDFVEFIKGGRLDSHLRHRRSSANATTTGQDMELYRQDKDQ 826
|.:|...:...:|.|||:.|:.||.|||:.:.| .:|.:|
Rat 432 NISLAKDSLLGIYGRRNIPPTHTQFDFVKLMDG----------------------KQLVKQ---- 470
Fly 827 SAESAQDQDSEQDESRSFDSSESYDVE-TPLDTAKQHLQRIGKPQSHWVNKRSAGDGLPALDVDA 890
||..|.|:: :|.:.....||..|
Rat 471 ------------------DSKSSDDIQHSPRNLILTSLQETG----------------------- 494
Fly 891 MTVNVSLLQYLDTGLWFISVYNDELVAHSVSLLAEEAEGVSTTCPNDCSGRGSCYLGKCDCIDGY 955
.::|:|.|.|:::.|||......|.:|....| :...|..:|:|.|.|..|.|.|..|:
Rat 495 ------FIEYMDQGPWYLAFYNDGKKMEQVFVLTTAIE-IMDDCSTNCNGNGECISGHCHCFPGF 552
Fly 956 QGVDCSKSVCPVLCSAHGHYGGGVCHCEEGWKGAECDIPVGECEVPNCSSHGRCIEGECHCERGW 1020
.|.||::..|||||..:|.|..|.|.|..||||.|||:|..:|..|.|..||.||.|.|.|..|:
Rat 553 LGPDCARDSCPVLCGGNGEYEKGHCVCRNGWKGPECDVPEEQCIDPTCFGHGTCIMGVCICVPGY 617
Fly 1021 KGPYCDQHDCLDPLCSGHGTCVAGQCYCKAGWQGEDCGTIDQQVYQCLPGCSEHGTYDLETGQCV 1085
||..|::.|||||:||.||.||.|:|:|..||.|.:|.| .:..|...||.|||:.|:||.|.
Rat 618 KGEICEEEDCLDPMCSSHGICVKGECHCSTGWGGVNCET---PLPICQEQCSGHGTFLLDTGVCS 679
Fly 1086 CERHWTGPDCSQAVCSLDCGRNGVCESGKCRCNSGWTGNLCDQLPCDSRCSEHGQCKNGTCVCSQ 1150
|:..|||.|||..:|:::||.:|||..|.|:|..||.|..|::..|.|.|:|||||::|.|.||.
Rat 680 CDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPTCEERSCHSHCAEHGQCRDGKCECSP 744
Fly 1151 GWNGRHCTL--------PGCENGCSRHGQCTLENGEYRCDCIEGWAGRDCSIALELNCKDNIDND 1207
||.|.|||: .||...|..:|:|||:...:.|.|..||:|..|:|.:|:.|.||:|||
Rat 745 GWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNIVMEMLCGDNLDND 809
Fly 1208 GDGMTDCSDSECCSHPACSEHIMCLSSNDPVEVLLRKQP---PSVTASFYQRVKFLIEENSVQSY 1269
|||:|||.|.:||....|....:|..|.||::::.:.|| ...:..||.|:||||.::|
Rat 810 GDGLTDCVDPDCCQQSNCYVSPLCQGSPDPLDLIQQSQPLFSQHTSRLFYDRIKFLIGKDS---- 870
Fly 1270 AHMDEYSENLFWSSFTPCRVSVMRGQVITPQGLGIVGIRVSVDRDSRFGFTLTRQGGWFDVLVNG 1334
.|:.... .||...|..|:||||:...|..:||:.||....|.:|||::||.|.||::..|
Rat 871 THVVPQE-----ISFDSRRACVIRGQVVAVDGTPLVGVNVSFLHHSDYGFTISRQDGSFDLVAIG 930
Fly 1335 GGAVTLQFQRSPFRPLTRTVFVPWNRIVVLPPVQMQLSDDDETTSRNIKVAPLNPALTFLNSIHY 1399
|.:|.|.|:||||....||:::|||:.:|:..|.|| |.:...|
Rat 931 GISVVLIFERSPFLSEKRTLWLPWNQFIVVEKVIMQ---------RIVADPP------------- 973
Fly 1400 HTADEANDASKVCMDHDHEKLRPQLISTWMPNGVGAMPGKRVIFAETQIVQESIQIPGSDLHLTY 1464
:.|.:|..|. .|.::.:.:.:..|:.|.:..|..|.|:|||.|.||.|.:.|:|
Rat 974 -SCDISNFISP----------NPIVLPSPLTSFGGSCPERGTIVPELQVVQEEIPIPSSFVRLSY 1027
Fly 1465 QSSQASGYLSIVRMRLTGETIPPTLTHVHVGVEIEGALHVKTYEADPSLVHTFAWNKRNVYRQKV 1529
.||:..||.:::|:.||..|||..:..||:.|.:||.|..|.:.|..:||:||||||.::|.|||
Rat 1028 LSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVAVEGRLTQKWFPAAINLVYTFAWNKTDIYGQKV 1092
Fly 1530 YGVTVARISVGYQHSTC-QSPVWIAQTAKLQGYDVDISDIGGWGLDIHHHYNFHEGILQKGDGST 1593
:|:..|.:||||::..| :..:|..:|..|||:::|.|::|||.|:.||.:|...||:.||:|..
Rat 1093 WGLAEALVSVGYEYEMCPEFILWEQRTVVLQGFEMDASNLGGWSLNKHHIFNPQSGIIHKGNGEN 1157
Fly 1594 LHMKEYPRTVKVVMGTGLQRPLTCPDYCNGVAKDAKLLTPIALATGPDGSLYVGDFNLVRRITPD 1658
:.:.:.|..:..:||.|.||.:.|.: |||.|.:.||..|:|||:|||||:||||||.||||.|.
Rat 1158 MFISQQPPVIATIMGNGHQRSVACTN-CNGPAHNNKLFAPVALASGPDGSVYVGDFNFVRRIFPS 1221
Fly 1659 GKVYTILQL------------------------------------SATQVSYQYYLAVSPADGHL 1687
|...:||:| .:|..:::||||:.|....|
Rat 1222 GNSVSILELRSTAPPFPLQKRTGFKEMTAKQNKTRYNKTRNRDTRHSTSPAHKYYLAMDPMSESL 1286
Fly 1688 YISDPERHQILRLVRLEKVKDPSINSDPVVGSGQRCIPGDEGNCGDGGPALLARLSHPKGLAIAA 1752
|:||....::.:|..|.:.||.|.|.:.|.|:|.:|:|.|:.:|||||.|..|.|:.|:|:.:..
Rat 1287 YLSDTNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCGDGGKASEASLNSPRGITVDR 1351
Fly 1753 DRTMYIADGTNIRAVDPKGVIHTLIGHHGHHNHWSPAPCSGTLMANQAQLQWPTGLALSPLDGSL 1817
...:|..|||.||.:|...||.|:||.:| .....|..|...:...|.:|:|||.||::|:|.||
Rat 1352 HGFIYFVDGTMIRRIDENAVITTVIGSNG-LTSTQPLSCDSGMDITQVRLEWPTDLAVNPMDNSL 1415
Fly 1818 HFIDDRLVLRLTSDMKIRVVAGTPLHCSNGGQDG-RVNKTGADNVLGTVLAMAFSPFGNLYIADS 1881
:.:|:.:||:::.:.::|::||.|:||...|.|. .|:|....:.|.:..|::.|..|.|:||::
Rat 1416 YVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFLVSKVAIHSTLESARAISVSHSGLLFIAET 1480
Fly 1882 DSRRVNSIRVVDTAGNMRYFAGKQEGTGSQTCDCAIGGGSNGSATNSGVGGAGGSAYSTTVNPTR 1946
|.|:||.|:.|.|.|.:...|| ....|||.|.
Rat 1481 DERKVNRIQQVTTNGEISIIAG-----APTDCDCKID---------------------------- 1512
Fly 1947 PNGGTTPTTPSGGNGNGNGNGSSATSSGGSVGGSNGSGGGANGGACICAGGIALSTGTGSSSGSN 2011
|| |.|..| :
Rat 1513 PN-------------------------------------------CDCFSG-------------D 1521
Fly 2012 GGGTLASIVGSGGLMSTGPTTTTTVLLGAKTTAAGIGAATLNDDGTLSNAETLLSSNARFQAISA 2076
|| .:.:|:.:|.|:
Rat 1522 GG---------------------------------------------------YAKDAKMKAPSS 1535
Fly 2077 IAVAQDGVINVADQGSLHVLALEHYLPSHDENGEFHIPFPPSSEIYVFNRYGQHVATKDLTSGKT 2141
:||:.||.:.|||.|::.:..:.......::...:.|..|...|:|.|...|.|:.|.:|.:...
Rat 1536 LAVSPDGTLYVADLGNVRIRTISKNQAHLNDMNLYEIASPADQELYQFTVNGTHLHTMNLITRDY 1600
Fly 2142 RYSFLYSKNTSFGRLSTVTDASGNKIQFLRDYSNVVSSIENTQDHKSEIQINGIGIMTKLSEKGR 2206
.|:|.|:.. |.|..:|.::||.:...||...:...:.........:.|:..|::.::|.:|.
Rat 1601 VYNFTYNAE---GDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTISSNGVLKRVSAQGY 1662
Fly 2207 QEIELDYDSNTGLLNSRSS-GGETYIYQYDEFGRVTGMILPSGEIVRITSQLADSQGLT-VYVHA 2269
....:.|..|||||.::|: .|.|.:|:||..|.:|....|:|| ::|..:|.:.|| |.:..
Rat 1663 NLALMTYPGNTGLLATKSNENGWTTVYEYDPEGHLTNATFPTGE---VSSFHSDLEKLTKVALDT 1724
Fly 2270 SVESLFSRERIAGEANELLVLGGVRSTF-LKRGQAHADAELKANNTLVIHGDNGVVVEAS----- 2328
| :||.:....| |....:.: ||:....:...:..:.:|.:...:|:.:..|
Rat 1725 S-----NRENVLMSTN----LTATSTIYILKQENTQSTYRVSPDGSLRVTFASGMEISLSSEPHI 1780
Fly 2329 -AVARHPLL---EAALPVEAEM-LAMWSHQSVTMGEGLTNSMYSVYSLVGDVRNPQQTLNREIWV 2388
|.|.:|.| ..:||.|... |..| .|.....:|..:: ..|.:..
Rat 1781 LAGAVNPTLGKCNISLPGEHNANLIEW-RQRKEQNKGNVSA-----------------FERRLRA 1827
Fly 2389 NQSRVIGVEFDQFTNRETFYDARRTPILIVAYDQSGLPKSYYPTNGY-PVNITYDRFNRVEGWAW 2452
:...::.::||..|.....||..|...|.:.|||:|.|..:.|.:.| .|||||.....|.....
Rat 1828 HNRNLLSIDFDHMTRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTFIQR 1892
Fly 2453 GPAELKYSYDRHGLLSEITSQ--QDG-IVSFVYNDWNLVSEIGLASQRKFVLQYDDAGGLRHVVL 2514
|....|..||:.| :|.|: .|| |.|:.|.:.::: :.|.|||:::.:||.:..|..|.:
Rat 1893 GTWNEKTDYDQSG---KIISRAWADGKIWSYTYLEKSVM--LLLHSQRRYIFEYDQSDCLLSVTM 1952
Fly 2515 PSGTRHSFSMQTSIGFIRCTYTPPGSTRAYLQHYSHAGALLQTILPGDGARIVYRYNAAGQLTEV 2579
||..|||.....|:|:.|..||||.|:.:::|.||..|.||||:..|.|.|::|:|....:|:|:
Rat 1953 PSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTLHLGTGRRVLYKYTKQARLSEI 2017
Fly 2580 VHGDGRSEFQYNEATGMPSTVSHTERE-----LEYRWDFEYAAGLLAEERIDYVAKTGLSNAKFS 2639
::...:....|.|::|:..|: |...: :.|| ..|.|...:|...::.||.||:|.
Rat 2018 LYDTTQVTLTYEESSGVIKTI-HLMHDGFICTIRYR-----QTGPLIGRQIFRFSEEGLVNARFD 2076
Fly 2640 YEYDSQLRVVALQGRIGGQSLPTQAFAYDPRTGRPSLIGQFRFSQPAQNQTQLHDGTASFTRTVD 2704
|.|:: .||.::|..|....||...:.|...:||....|:|.......||. :.......|:..:
Rat 2077 YSYNN-FRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQV-ITTTVMKHTKIFN 2139
Fly 2705 GRFQTQRMALAIHRLEVFRMEFSYGVHGRISQTRTYTRNMAVNSYTNVKN--YTWDCDGQL--VG 2765
...|...:...|.:...:.|...|...||: ...::.|....|:.. |.:|.|||| |.
Rat 2140 ANGQVIEVQYEILKAIAYWMTIQYDNMGRM-----VICDIRVGVDANITRYFYEYDADGQLQTVS 2199
Fly 2766 VEAQEPWGFRYDDNGNLLSLTYRGNT---IPMEYNAQDRIVKFGEGQYKYDARGLVAQNAREERF 2827
|..:..|.:.||.||| ::|...||: .|:.|:.:|||.:.||.|||.|..|.:.|.. .:.|
Rat 2200 VNDKTQWRYSYDLNGN-INLLSHGNSARLTPLRYDLRDRITRLGEIQYKMDEDGFLRQRG-NDIF 2262
Fly 2828 HYNTQGLLVRA-SKRGRFDVRYYYDHLKRLTTRKDNFGNVTQFFYTNQQRPYEVSQIYSPRDGKL 2891
.||:.|||.:| :|...:.|:||||.|.|....|.:.|...||||.:...|..|:.:|:....::
Rat 2263 EYNSNGLLQKAYNKVSGWTVQYYYDGLGRRVASKSSLGQHLQFFYADLANPIRVTHLYNHTSSEI 2327
Fly 2892 MSLTYDDVGHLIYAQVYR-HKYYVATDQSGTPLMLFNQYGEGIREIMRSPFGHIVYDSNPYLYLP 2955
.||.||..||||..::.. .:||||.|.:||||.:|:..|:.|:||:.:|:|.|.:|:.|...:.
Rat 2328 TSLYYDLQGHLIAMELSSGEEYYVACDNTGTPLAVFSSRGQVIKEILYTPYGDIYHDTYPDFEVV 2392
Fly 2956 IDFCGGILDQVTTLVHMGDGRVYDPLIGQWMSPD---WQRVAERIITPTRLHLYRFNGNDPI-NV 3016
|.|.||:.|.:|.|||:|. |.||.:.|:|.:|: |:::. :.|...:||.|..|.|: .:
Rat 2393 IGFHGGLYDFLTKLVHLGQ-RDYDVVAGRWTTPNHHIWKQLN---LLPKPFNLYSFENNYPVGKI 2453
Fly 3017 GHERHYPEDFAAWMRTLGYNVGNLVPQLARDLWQPPALWGRPPANPVALNLRRPFD--NIPTMAV 3079
.....|..|..:|:...|:.:.|::| |.| .|...|:...:: .:.|...
Rat 2454 QDVAKYTTDIGSWLELFGFQLHNVLP-------------GFP--KPELENMELTYELLQLQTKTQ 2503
Fly 3080 E-------SGFLAHL--NVRRMSDFEQLSAPPR-SALKCDVMDPSPKTIGSDTEPPFGKGIVVSR 3134
| .|....| .:|.....:||...|: :..:|......|:. :.....||||| :
Rat 2504 EWDPGKMILGIQCELQKQLRNFISLDQLPMTPQYNEGRCLEGGKQPRF--AAVPSVFGKGI---K 2563
Fly 3135 TADGQAIVSS--VPAANAIYRDVYTSVFNRSKLLPFTFVVHNAQQDSFFFVKEDAWRATEDRQQL 3197
.|..:.||:: :..||...|.:...:.|...|....|.:.. :|:.:|:|..: ..||...:
Rat 2564 FAIKEGIVTADIIGVANEDSRRLAAILNNAHYLENLHFTIEG--RDTHYFIKLGS--LEEDLVLI 2624
Fly 3198 ------KRLQGQVNTTFHEITREATVGSGPAGAANGGAGSSSSSSSSSGGGSSSNTGNYLDVKI- 3255
:.|:..||.|..::| ...|| .|..:.|:::
Rat 2625 GNTGGRRILENGVNVTVSQMT----------SVLNG------------------RTRRFADIQLQ 2661
Fly 3256 HGAHAIINLRYGTTVAKEQQRLMHHAKLTAVRKAWHREKEALRSGLTTALEWSQQETDEILKQSY 3320
||| ...|:||||||.:|:..::..|:..||.:||.:|:..|:.|......|::.|..::|....
Rat 2662 HGA-LCFNIRYGTTVEEEKNHVLEMARQRAVAQAWTQEQRRLQEGEEGTRVWTEGEKQQLLGTGR 2725
Fly 3321 ANNYEGEYIHDVNLYPELAEDPYNIKFVKK 3350
...|:|.::..|..|.||::...||.|:::
Rat 2726 VQGYDGYFVLSVEQYLELSDSANNIHFMRQ 2755
| 
