DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ten-a and Wif1

DIOPT Version :9

Sequence 1:	NP_001162732.2	Gene:	Ten-a / 32183	FlyBaseID:	FBgn0267001	Length:	3387	Species:	Drosophila melanogaster
Sequence 2:	NP_036045.1	Gene:	Wif1 / 24117	MGIID:	1344332	Length:	379	Species:	Mus musculus

Alignment Length:	359	Identity:	93/359 - (25%)
Similarity:	133/359 - (37%)	Gaps:	113/359 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   867 GK--PQSHWVNKRSAGDGLPALDVDAMTVNVS--------------LLQYLDTGLWFISVYNDEL 915
            ||  |.:|  :.|.|...:||:.|:..::|.:              .|:.||.|:......|..|
Mouse    61 GKMAPFTH--DFRKAQQRMPAIPVNIHSMNFTWQAAGQAEYFYEFLSLRSLDKGIMADPTVNVPL 123

  Fly   916 ---VAHSVSLLAEEAEGVSTTCPNDCSGRGSCYLGKCDCIDGYQGVDCSKSVCPVLCSAHGHYGG 977
               |.|..|::.     |...|           |||.|.:..::       |..::.::.|:
Mouse   124 LGTVPHKASVVQ-----VGFPC-----------LGKQDGVAAFE-------VNVIVMNSEGN--- 162

  Fly   978 GVCH----------CEEGWKGAECDIPVGECEVPNCSSHGRCIEGE-CHCERGWKGPYCDQHDCL 1031
            .:..          |::    |||  |.|      |.:.|.|.|.. |.|..|:.||:|::..|:
Mouse   163 TILRTPQNAIFFKTCQQ----AEC--PGG------CRNGGFCNERRVCECPDGFYGPHCEKALCI 215

  Fly  1032 DPLCSGHGTCVAGQCYCKAGWQGEDCGTIDQQVYQCLPGCSEHGTYDLETGQCVCERHWTGPDCS 1096
             |.|...|.||.                                     .|.|:|...:.|.:|.
Mouse   216 -PRCMNGGLCVT-------------------------------------PGFCICPPGFYGVNCD 242

  Fly  1097 QAVCSLDCGRNGVC-ESGKCRCNSGWTGNLCDQLPCDSRCSEHGQC-KNGTCVCSQGWNGRHCTL 1159
            :|.||..|...|.| ..|||.|..|..|..|:...|...|...|:| ....|.|.:|:.|..|:.
Mouse   243 KANCSTTCFNGGTCFYPGKCICPPGLEGEQCELSKCPQPCRNGGKCIGKSKCKCPKGYQGDLCSK 307

  Fly  1160 PGCENGCSRHGQCTLENGEYRCDCIEGWAGRDCS 1193
            |.||.||..||.|...|   :|.|.|||.||.|:
Mouse   308 PVCEPGCGAHGTCHEPN---KCQCREGWHGRHCN 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ten-a	NP_001162732.2	EGF_2	934..960	CDD:285248	5/25 (20%)
		Keratin_B2	998..1162	CDD:279797	44/166 (27%)
		EGF_2	<1003..1025	CDD:285248	9/22 (41%)
		EGF_2	1032..1057	CDD:285248	5/24 (21%)
		EGF_2	<1071..1095	CDD:285248	4/23 (17%)
		EGF_2	1101..1126	CDD:285248	10/25 (40%)
		EGF_2	<1135..1157	CDD:285248	7/22 (32%)
		EGF_CA	1163..1192	CDD:238011	14/28 (50%)
		NHL	1622..1927	CDD:302697
		NHL repeat	1675..1721	CDD:271320
		NHL repeat	1745..1787	CDD:271320
		NHL repeat	1802..1847	CDD:271320
		NHL repeat	1864..1897	CDD:271320
		RHS_repeat	2213..2250	CDD:283287
		RhsA	2397..2958	CDD:225750
		Rhs_assc_core	2939..3015	CDD:274730
		Tox-GHH	3274..3349	CDD:292269
Wif1	NP_036045.1	WIF	35..179	CDD:128745	28/145 (19%)
Wif1	NP_036045.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..379
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1225
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810