Protein Alignment Ten-a and Tenm3

DIOPT Version :10

• Sequence 1: NP_001162732.2
• Gene: Ten-a / 32183
• FlyBaseID: FBgn0267001
• Length: 3387
• Species: Drosophila melanogaster
• Sequence 2: XP_036009877.1
• Gene: Tenm3 / 23965
• MGIID: 1345183
• Length: 2765
• Species: Mus musculus
• Alignment Length: 3207
• Identity: 898/3207 - (28%)
• Similarity: 1406/3207 - (43%)
• Gaps: 701/3207 - (21%)

  Fly   240 PSASSSTAASSSIRSSHRNRNALNRLSGMTSSSSD--------SQTHHHQQQQQQQQQQQQQQQQ 296
            |||:....:|.|:......|:.......:|.|:.|        |..|.|.:..::|:|......|
Mouse   158 PSAAGCKQSSFSLSCLAAARSRSPEPGAVTRSAPDPGKLAAPGSAPHGHGEGARRQEQPSNNPGQ 222

  Fly   297 QQLQISQQQQQQIAAVKQQQQMLPPEDSGDDDFVLGLGSLELGNCSSGGESEEPPPEPAPPEIPP 361
            ..||......:|..|     |..|           .:.||...:.::.......||...|.|:..
Mouse   223 PTLQPLPPSHKQHPA-----QHHP-----------SITSLNRNSLTNRRNQSPAPPAALPAELQT 271

  Fly   362 RTQSLLMSLRKHSDYKLKYEEKGDQKHEEFIPTSQLQKDYILSDNLRSDQQLKPISPGDSNGLGG 426
            ..:|:                             |||..::|..|:          |.:|...
Mouse   272 TPESV-----------------------------QLQDSWVLGSNV----------PLESRHF-- 295

  Fly   427 HPQQMPQSMSTGSNTIGHGGIDRGGVGLPMGAGTMPGGVGGGPGGVAGGGPQVGVGPPGSGNGGN 491
                   ...||:.|            .|:.:...||..      :|.|..   ..||
Mouse   296 -------LFKTGTGT------------TPLFSTATPGYT------MASGSV---YSPP------- 325

  Fly   492 CQISGSQPLVMPGFPLRNSHSAHAPHYSPYSPSRFHIDKRCQHRCSWKCLSIALIFVSVVLTAML 556
                 ::||.      ||:          .|.|.|...|..:: |||:|.::..:.|||:|..:|
Mouse   326 -----TRPLP------RNT----------LSRSAFKFKKSSKY-CSWRCTALCAVGVSVLLAILL 368

  Fly   557 AYFAAVSSMKPNMDSTNCILVQDVKSQPHDLRGGLAKSNEKGVATAFPTEESIQTSTSDHGQNGH 621
            :||.|:.                                      .|.....:|.:.:|..:||
Mouse   369 SYFIAMH--------------------------------------LFGLNWHLQQTENDTFENG- 394

  Fly   622 GLMNPSAGSGGSNSGIQQQLLLQQQQPHSINQPLTPLDATNTHLQDHHQLTYGGALPGG----VG 682
                                        .:|....|   |||           .:||.|    :|
Mouse   395 ----------------------------KVNSDTVP---TNT-----------VSLPSGDNGKLG 417

  Fly   683 GIGMSGGGIMNGGLNGGLGGQLMQQPGGGLNGHHHQALQPQLGGVVELKEFNEAYHATIPAYQFW 747
            |.......|.:|.|:  :|.:.:|:                                 :|...||
Mouse   418 GFTHENNTIDSGELD--IGRRAIQE---------------------------------VPPGIFW 447

  Fly   748 TLEFRNKHPAFIRFNFTLPWGAHFAVYSRRNVAPSVTQHDFVEFIKGGRLDSHLRHRRSSANATT 812
            ..:.....|.|::||.:|...|...||.|:.:.||.||:||||.:.|.||.:.
Mouse   448 RSQLFIDQPQFLKFNISLQKDALIGVYGRKGLPPSHTQYDFVELLDGSRLIAR------------ 500

  Fly   813 TGQDMELYRQDKDQSAESAQDQDSEQDESRSFDSSESYDVETPLDTAKQHLQRIGKPQSHWVNKR 877
                                       |.|:...||                |.|: |:..|:..
Mouse   501 ---------------------------EQRNLVESE----------------RAGR-QARSVSLH 521

  Fly   878 SAGDGLPALDVDAMTVNVSLLQYLDTGLWFISVYNDELVAHSVSLLAEEAEGVSTTCPNDCSGRG 942
            .||                .:||||:|:|.::.|||......||......|.| ..||.:|.|.|
Mouse   522 EAG----------------FIQYLDSGIWHLAFYNDGKNPEQVSFNTIVIESV-VECPRNCHGNG 569

  Fly   943 SCYLGKCDCIDGYQGVDCSKSVCPVLCSAHGHYGGGVCHCEEGWKGAECDIPVGECEVPNCSSHG 1007
            .|..|.|.|..|:.|.|||::.||||||.:|.|..|.|.|..||||.|||:|..:|..|.|...|
Mouse   570 ECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRG 634

  Fly  1008 RCIEGECHCERGWKGPYCDQHDCLDPLCSGHGTCVAGQCYCKAGWQGEDCGTIDQQVYQCLPGCS 1072
            .||.|.|.|..|:||..|::.|||||.||.||.|:.|:|:|..||.|.:|..:..   .|...||
Mouse   635 ICIMGSCACNSGYKGENCEEADCLDPGCSNHGVCIHGECHCNPGWGGSNCEILKT---MCADQCS 696

  Fly  1073 EHGTYDLETGQCVCERHWTGPDCSQAVCSLDCGRNGVCESGKCRCNSGWTGNLCDQLPCDSRCSE 1137
            .||||..|:|.|.|:.:|||||||..:||:|||.:|||..|.|||..||||..|:|..|..||:|
Mouse   697 GHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGSCRCEEGWTGPACNQRACHPRCAE 761

  Fly  1138 HGQCKNGTCVCSQGWNGRHCTL----------------PGCENGCSRHGQCTLENGEYRCDCIEG 1186
            ||.||:|.|.|||||||.|||:                .||...|:.:|:|||:...:.|.|..|
Mouse   762 HGTCKDGKCECSQGWNGEHCTIAHYLDKIVKADKIGYKEGCPGLCNSNGRCTLDQNGWHCVCQPG 826

  Fly  1187 WAGRDCSIALELNCKDNIDNDGDGMTDCSDSECCSHPACSEHIMCLSSNDPVEVLLRK-QPPSVT 1250
            |.|..|.:|:|..|.|:.||:|||:.||.|.:||...:|.....|....||.:::.:. |.||..
Mouse   827 WRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYCRGLPDPQDIISQSLQTPSQQ 891

  Fly  1251 A--SFYQRVKFLIEENSVQSYAHMDEYSENLFWSSFTPCRVSVMRGQVITPQGLGIVGIRVSVDR 1313
            |  |||.|:.|||..:|.........::::|         .||:||||:|..|..::|:.||...
Mouse   892 AAKSFYDRISFLIGSDSTHVLPGESPFNKSL---------ASVIRGQVLTADGTPLIGVNVSFLH 947

  Fly  1314 DSRFGFTLTRQGGWFDVLVNGGGAVTLQFQRSPFRPLTRTVFVPWNRIVVLPPVQMQLSDDDETT 1378
            .|.:|:|:|||.|.||::.|||.::||.|:||||.....||::|||...|:..:.|:..::|..:
Mouse   948 YSEYGYTITRQDGMFDLVANGGASLTLVFERSPFLTQYHTVWIPWNVFYVMDTLVMKKEENDIPS 1012

  Fly  1379 ---SRNIKVAPL---NPALTFLNSIHYHTADEANDASKVCMDHDHEKLRPQLISTWMPNGVGAMP 1437
               |..::.:|:   :|..||..|                                       .|
Mouse  1013 CDLSGFVRPSPIIVSSPLSTFFRS---------------------------------------SP 1038

  Fly  1438 GKRVIFAETQIVQESIQIPGSDLHLTYQSSQASGYLSIVRMRLTGETIPPTLTHVHVGVEIEGAL 1502
            ....|..|||::.|...|||:||.|:|.||:|:||.|::::.:|...||..|..||:.|.:.|.|
Mouse  1039 EDSPIIPETQVLHEETTIPGTDLKLSYLSSRAAGYKSVLKITMTQAVIPFNLMKVHLMVAVVGRL 1103

  Fly  1503 HVKTYEADPSLVHTFAWNKRNVYRQKVYGVTVARISVGYQHSTC-QSPVWIAQTAKLQGYDVDIS 1566
            ..|.:.|.|:|.:||.|:|.:.|.|||||::.|.:||||::.:| ...:|..:||.||||::|.|
Mouse  1104 FQKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVVSVGYEYESCLDLTLWEKRTAVLQGYELDAS 1168

  Fly  1567 DIGGWGLDIHHHYNFHEGILQKGDGSTLHMKEYPRTVKVVMGTGLQRPLTCPDYCNGVAKDAKLL 1631
            ::|||.||.||..:...|||.||:|....:.:.|..|..:||.|.:|.::||. |||.|...|||
Mouse  1169 NMGGWTLDKHHVLDVQNGILYKGNGENQFISQQPPVVSSIMGNGRRRSISCPS-CNGQADGNKLL 1232

  Fly  1632 TPIALATGPDGSLYVGDFNLVRRITPDGKVYTILQL------SATQVSYQYYLAVSPADGHLYIS 1690
            .|:|||.|.||||||||||.||||.|.|.|.::|:|      .::..:::||||..|..|.||:|
Mouse  1233 APVALACGIDGSLYVGDFNYVRRIFPSGNVTSVLELRNKDFRHSSNPAHRYYLATDPVTGDLYVS 1297

  Fly  1691 DPERHQILRLVRLEKVKDPSINSDPVVGSGQRCIPGDEGNCGDGGPALLARLSHPKGLAIAADRT 1755
            |....:|.|...|...||.:.|::.|.|:|::|:|.||..|||||.|:.|.|..|||:||..:..
Mouse  1298 DTNTRRIYRPKSLTGAKDLTKNAEVVAGTGEQCLPFDEARCGDGGKAVEATLMSPKGMAIDKNGL 1362

  Fly  1756 MYIADGTNIRAVDPKGVIHTLIGHHGHHNHWSPAPCSGTLMANQAQLQWPTGLALSPLDGSLHFI 1820
            :|..|||.||.||..|:|.||:|.:...:. .|..|..::..:|.:|:|||.||::|:|.|::.:
Mouse  1363 IYFVDGTMIRKVDQNGIISTLLGSNDLTSA-RPLTCDTSMHISQVRLEWPTDLAINPMDNSIYVL 1426

  Fly  1821 DDRLVLRLTSDMKIRVVAGTPLHCSNGGQDGRVNKTGADNVLGTVLAMAFSPFGNLYIADSDSRR 1885
            |:.:||::|.:.::|:.||.|:||...|.:..|.|......|.:..|:|.|..|.|||.::|.::
Mouse  1427 DNNVVLQITENRQVRIAAGRPMHCQVPGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEKK 1491

  Fly  1886 VNSIRVVDTAGNMRYFAGKQEGTGSQTCDCAIGGGSNGSATNSGVGGAGGSAYSTTVNPTRPNGG 1950
            :|.||.|.|.|.:...||.     ...|||
Mouse  1492 INRIRQVTTDGEISLVAGI-----PSECDC----------------------------------- 1516

  Fly  1951 TTPTTPSGGNGNGNGNGSSATSSGGSVGGSNGSGGGANGGACICAGGIALSTGTGSSSGSNGGGT 2015
                                                .|...|.|     ..:|.|
Mouse  1517 ------------------------------------KNDANCDC-----YQSGDG---------- 1530

  Fly  2016 LASIVGSGGLMSTGPTTTTTVLLGAKTTAAGIGAATLNDDGTLSNAETLLSSNARFQAISAIAVA 2080
                                                             .:.:|:..|.|::|.:
Mouse  1531 -------------------------------------------------YAKDAKLNAPSSLAAS 1546

  Fly  2081 QDGVINVADQGSLHVLALEHYLPSHDENGEFHIPFPPSSEIYVFNRYGQHVATKDLTSGKTRYSF 2145
            .||.:.:||.|::.:.|:....|..:....:.:..|...|:|:|:..|.|..|..|.:|...|:|
Mouse  1547 PDGTLYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQELYIFDINGTHQYTVSLVTGDYLYNF 1611

  Fly  2146 LYSKNTSFGRLSTVTDASGNKIQFLRDYSNVVSSIENTQDHKSEIQINGIGIMTKLSEKGRQEIE 2210
            .||.:..   ::.|||::||.::..||.:.:...:.:..:....:.|...|.:..::.:|.:.:.
Mouse  1612 SYSNDND---VTAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVL 1673

  Fly  2211 LDYDSNTGLLNSRS-SGGETYIYQYDEFGRVTGMILPSGEIVRITSQLADSQGLTVYVHASVESL 2274
            ..|..|:|||.::| ..|.|..:.||..||:|.:..|:|.:..:...:  .:.:||.:.:|
Mouse  1674 FTYHGNSGLLATKSDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGDM--DKAITVDIESS---- 1732

  Fly  2275 FSRERIAGEANEL--------LVLGGVRSTFLKRGQAHADAELKANNTLVIHGDNGVVVEASAVA 2331
             |||......:.|        :|...:|:::    |...|..|:             :..||.:.
Mouse  1733 -SREEDVSITSNLSSIDSFYTMVQDQLRNSY----QIGYDGSLR-------------IFYASGLD 1779

  Fly  2332 RHPLLEAALPVEAEMLAMWSHQSVTM---------GEGLTNSMYSVYSLVGDVRNPQQTLNREIW 2387
            .|      ...|..:||..::.:|..         |:.|....:......|.|    ....|::.
Mouse  1780 SH------YQTEPHVLAGTANPTVAKRNMTLPGENGQNLVEWRFRKEQAQGKV----NVFGRKLR 1834

  Fly  2388 VNQSRVIGVEFDQFTNRETFYDARRTPILIVAYDQSGLPKSYYPTNG-YPVNITYDRFNRVEGWA 2451
            ||...::.|:||:.|..|..||..|..:|.:|||.||.|..:.|::. ..||:||....::....
Mouse  1835 VNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLPSSKLMAVNVTYSSTGQIASIQ 1899

  Fly  2452 WGPAELKYSYDRHG-LLSEITSQQDGIV-SFVYNDWNLVSEIGLASQRKFVLQYDDAGGLRHVVL 2514
            .|....|..||..| ::|.:.:  ||.. |:.|.:.::|  :.|.|||:::.:||....|..:.:
Mouse  1900 RGTTSEKVDYDSQGRIVSRVFA--DGKTWSYTYLEKSMV--LLLHSQRQYIFEYDMWDRLSAITM 1960

  Fly  2515 PSGTRHSFSMQTSIGFIRCTYTPPGSTRAYLQHYSHAGALLQTILPGDGARIVYRYNAAGQLTEV 2579
            ||..||:.....|||:.|..|.||.|..:.:..|:..|.||||...|...|::::|....:|:|:
Mouse  1961 PSVARHTMQTIRSIGYYRNIYNPPESNASIITDYNEEGLLLQTAFLGTSRRVLFKYRRQTRLSEI 2025

  Fly  2580 VHGDGRSEFQYNEATGMPSTVSHTER----ELEYRWDFEYAAGLLAEERIDYVAKTGLSNAKFSY 2640
            ::...|..|.|:|..|:..||:....    .:.||     ..|.|.:.:|...::.|:.||:|.|
Mouse  2026 LYDSTRVSFTYDETAGVLKTVNLQSDGFICTIRYR-----QIGPLIDRQIFRFSEDGMVNARFDY 2085

  Fly  2641 EYDSQLRVVALQGRIGGQSLPTQAFAYDPRTGRPSLIGQFRFSQPAQNQTQLHDGTASFTRTVDG 2705
            .||:..||.::||.|....||...:.:|..:|:....|:|.......||. :.....::|:..|.
Mouse  2086 SYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDINQI-ISTAVMTYTKHFDA 2149

  Fly  2706 RFQTQRMALAIHRLEVFRMEFSYGVHGRISQTRTYTRNMAVNSYTNVKNYT--WDCDGQLVGVEA 2768
            ..:.:.:...|.|..::.:...|...||:::     |.:.:..:.|...|.  :|.||||..|..
Mouse  2150 HGRIKEIQYEIFRSLMYWITIQYDNMGRVTK-----REIKIGPFANTTKYAYEYDVDGQLQTVYL 2209

  Fly  2769 QEP--WGFRYDDNGN--LLSLTYRGNTIPMEYNAQDRIVKFGEGQYKYDARGLVAQNAREERFHY 2829
            .|.  |.:.||.|||  ||:.:......|:.|:.:|||.:.|:.||:.|..|.:.|.. .|.|.|
Mouse  2210 NEKIMWRYNYDLNGNLHLLNPSSSARLTPLRYDLRDRITRLGDVQYRLDEDGFLRQRG-TEIFEY 2273

  Fly  2830 NTQGLLVRA-SKRGRFDVRYYYDHLKRLTTRKDNFGNVTQFFYTNQQRPYEVSQIYSPRDGKLMS 2893
            :::|||.|. ||...:.|.|.||.|.|..:.|.:.|...||||.:...|..::.:|:....::.|
Mouse  2274 SSKGLLTRVYSKGSGWTVIYRYDGLGRRVSSKTSLGQHLQFFYADLTYPTRITHVYNHSSSEITS 2338

  Fly  2894 LTYDDVGHLIYAQVYR-HKYYVATDQSGTPLMLFNQYGEGIREIMRSPFGHIVYDSNPYLYLPID 2957
            |.||..|||...::.. .::|:|:|.:||||.:|:..|..:::|..:.:|.|.:|||....|.|.
Mouse  2339 LYYDLQGHLFAMEISSGDEFYIASDNTGTPLAVFSSNGLMLKQIQYTAYGEIYFDSNVDFQLVIG 2403

  Fly  2958 FCGGILDQVTTLVHMGDGRVYDPLIGQWMSPD---WQRVAERIITPTRLHLYRFNGNDPINVGHE 3019
            |.||:.|.:|.|:|.|: |.||.|.|:|.:||   |:|:.:   .|...:||.|..|:|.:..|:
Mouse  2404 FHGGLYDPLTKLIHFGE-RDYDILAGRWTTPDIEIWKRIGK---DPAPFNLYMFRNNNPASKIHD 2464

  Fly  3020 -RHYPEDFAAWMRTLGYNVGNLVPQL---ARDLWQPPALWGRPPANPVALNLRRPFDNIPTM--- 3077
             :.|..|..:|:.|.|:::.|.:|..   ..||.:|          ...|...:.::::|.:
Mouse  2465 VKDYITDVNSWLVTFGFHLHNAIPGFPVPKFDLTEP----------SYELVKSQQWEDVPPIFGV 2519

  Fly  3078 --AVESGFLAHLNVRRMSDFEQLSAPPRSALKCDVMDPSPKTIGSDTEPPFGKGIVVSRTADGQA 3140
              .|.....|.|::.:|::. |:|.....|.:..:...:.|::       .|||:::: .:.|:.
Mouse  2520 QQQVARQAKAFLSLGKMAEV-QVSRRKAGAEQSWLWFATVKSL-------IGKGVMLA-VSQGRV 2575

  Fly  3141 IVSSVPAANAIYRDVYTSVFNRSKLLPFTFVVHNAQQDSFFFVKE-------DAWRATEDRQQLK 3198
            ..:.:..||.....|...:.|...|....|.:..  :|:.:|:|.       ...|.|..|   |
Mouse  2576 QTNVLNIANEDCIKVAAVLNNAFYLENLHFTIEG--KDTHYFIKTTTPESDLGTLRLTSGR---K 2635

  Fly  3199 RLQGQVNTTFHEITREATVGSGPAGAANGGAGSSSSSSSSSGGGSSSNTGNYLDVKIHGAHAIIN 3263
            .|:..:|.|   :::..||.:|                         .|..:.||::......::
Mouse  2636 ALENGINVT---VSQSTTVVNG-------------------------RTRRFADVEMQFGALALH 2672

  Fly  3264 LRYGTTVAKEQQRLMHHAKLTAVRKAWHREKEALRSGLTTALEWSQQETDEILKQSYANNYEGEY 3328
            :|||.|:.:|:.|::..|:..|:.:||.||::.:|.|...|..|::.|..::|.......|:|.|
Mouse  2673 VRYGMTLDEEKARILEQARQRALARAWAREQQRVRDGEEGARLWTEGEKRQLLSAGKVQGYDGYY 2737

  Fly  3329 IHDVNLYPELAEDPYNIKFVKK 3350
            :..|..|||||:...||:|:::
Mouse  2738 VLSVEQYPELADSANNIQFLRQ 2759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ten-a	NP_001162732.2	acid_disulf_rpt	1199..1225	CDD:411265	12/25 (48%)
		NHL	1622..1927	CDD:302697	124/310 (40%)
		NHL repeat	1675..1721	CDD:271320	18/45 (40%)
		NHL repeat	1745..1787	CDD:271320	18/41 (44%)
		NHL repeat	1802..1847	CDD:271320	19/44 (43%)
		NHL repeat	1864..1897	CDD:271320	13/32 (41%)
		RHS_core	<2118..>2248	CDD:469161	36/130 (28%)
		RhsA	<2366..3015	CDD:442442	205/666 (31%)
		Tox-GHH	3272..3349	CDD:464783	26/76 (34%)
		EGF_2	937..960	CDD:400365	9/22 (41%)
		EGF_2	1003..1025	CDD:400365	10/21 (48%)
		EGF_2	1034..1057	CDD:400365	11/22 (50%)
		C_rich_MXAN6577	<1035..1146	CDD:469225	57/110 (52%)
		EGF_CA	1163..1192	CDD:238011	10/28 (36%)
Tenm3	XP_036009877.1	Ten_N	<192..351	CDD:461932	47/272 (17%)
		DUF5885	565..750	CDD:437064	95/187 (51%)
		DSL	741..784	CDD:473190	27/42 (64%)
		EGF_CA	803..832	CDD:238011	10/28 (36%)
		acid_disulf_rpt	835..865	CDD:411265	14/29 (48%)
		NHL	1205..1564	CDD:302697	146/500 (29%)
		NHL repeat	1234..1273	CDD:271323	24/38 (63%)
		NHL repeat	1285..1328	CDD:271323	16/42 (38%)
		NHL repeat	1352..1386	CDD:271323	17/33 (52%)
		NHL repeat	1408..1447	CDD:271323	16/38 (42%)
		NHL repeat	1470..1503	CDD:271323	13/32 (41%)
		RhsA	1518..2458	CDD:442442	279/1060 (26%)
		NHL repeat	1538..1564	CDD:271323	8/25 (32%)
		Tox-GHH	2681..2758	CDD:464783	26/76 (34%)