DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ten-a and T01D3.1

DIOPT Version :9

Sequence 1:NP_001162732.2 Gene:Ten-a / 32183 FlyBaseID:FBgn0267001 Length:3387 Species:Drosophila melanogaster
Sequence 2:NP_001256538.1 Gene:T01D3.1 / 179859 WormBaseID:WBGene00011326 Length:3226 Species:Caenorhabditis elegans


Alignment Length:3390 Identity:611/3390 - (18%)
Similarity:1019/3390 - (30%) Gaps:1242/3390 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 AEWHSHGR-HGHGHGLSHGMGHGMGHGYGS--SSEDEYQNTGQATAFDTQLLAQLLLQSQQLASM 116
            :|.|...| |.|.||.|           ||  .:.|.|      :..:.::.|::...::.||  
 Worm   134 SECHRAARNHNHRHGKS-----------GSILRAVDPY------SQLEAEMEAEIEAGARALA-- 179

  Fly   117 EHYNSDCEPDYLR-QRDRHHEEATPLGDGTPTVTAAAPEVTYAQPHQQRSTMPAGSPLKVSTVSA 180
            ........|...| :|.|...|.....|....|.....|:|      :...:|.||.|.|:..|.
 Worm   180 RALTPSTPPVTTRSRRVRRDVEDITKQDQDVQVMHGDQEIT------EDKVVPVGSQLDVAAGSK 238

  Fly   181 GKYQSNANLGLFPNSSSSGGSSVQNGVTAHTPRSTNPFLNGSTKFASDDGGLENINMLKPSASSS 245
            .|::....|.::.:.:..|.:   |......|.:.|....|.....|.:..|.::|:.....:.|
 Worm   239 WKFRKGVGLVVYGSLNLKGNT---NQPIIFEPSTKNARWRGIEFRNSSESSLTHVNITGADVAVS 300

  Fly   246 TAASSSIRSSH--RNRNALN-RLSGMTSSSSDSQTHHHQQQQQQQQQQQQQQQQQQLQISQQQQQ 307
            ..:.:|....|  .:.|... ::|.|.|||:   ||                           .:
 Worm   301 VKSGTSPDMDHVVVDGNVYGVQISDMDSSST---TH---------------------------LK 335

  Fly   308 QIAAVKQQQQMLPPEDSGDDDFVLGLGSLELGNCSSGGESEEPPPEPAPPEIPPRTQSLLMSLRK 372
            .:.:|..       |.:|.:  .||.||:.:....|....|                   :.:..
 Worm   336 SVVSVNN-------EKTGIE--YLGKGSISIDRAVSASNGE-------------------VGISI 372

  Fly   373 HSDYKLKYEEKGDQKHEE---FIPTSQLQKDYILSDNLRSDQQLKPISPGDSNGLGG-HPQQMPQ 433
            .:|.|:.........::.   ::.||::..:.::.               ::||..| |.:...:
 Worm   373 STDQKVTIRRSSSYSNKATGIYVGTSEITIENVVV---------------NANGFYGIHAEVEKR 422

  Fly   434 SMSTGSNTIGHGGIDRGGVGLPMGAGTMPGGVGGGPGGVAGGGPQVGVGPP--GSGNGGNCQISG 496
            ....|.|...|    ||...|.:               ...|..::|:...  .....|..::||
 Worm   423 FEMDGVNVSAH----RGEFALEL---------------FMSGNAKIGIANSRFHDNKKGGVRVSG 468

  Fly   497 SQPLVMPGFPLRN----SHSAHAPHYSPYSPSRFHIDKRCQHRCSWKCLSIALIFV------SVV 551
            .  ...|...||:    .:|.....::.:..|...::         ||..:...::      |||
 Worm   469 K--FQSPNVILRDCRFLRNSGEIIIFNEFGQSSLSVE---------KCEFLNNNYIDFDGGDSVV 522

  Fly   552 LTAMLAYFAAVSSMKPNMDSTNCILVQD---VKSQPHDLRGGLAK---------SNE--KGVATA 602
                        |:| |::....|.:.:   .|:..||:...|..         .||  :.:|.:
 Worm   523 ------------SIK-NVNENGKISISNNKFTKNTMHDIVKLLESVPSSEIFITDNEFNQNLANS 574

  Fly   603 FPTEESIQTSTSDH-----------GQNG------HGLMNPSAGSGGSN---SGIQQQLLLQQQQ 647
            ..|..|:..|.|::           ..|.      ..|......||.:|   :|:..| .:|...
 Worm   575 IITTNSVNISISENLFQDKRSTCEITYNSPAMPKIEDLTQNKMLSGNTNPICTGLGYQ-TIQMDA 638

  Fly   648 PHSINQPLTPLDATNTHLQDHHQLTYGGALPG--------GVG-----------------GIGMS 687
            |.| :.||..:..|....::...|....:.|.        .||                 ||.:|
 Worm   639 PIS-STPLPLVGVTENPFKNQKGLIKASSEPYIINEEVLINVGEIVVIEPGAIFDFAPGVGITVS 702

  Fly   688 GGGIMNG---------GLNGGLGGQLMQQPGGGL------------------------NGHHHQA 719
            |..:|||         |.||.....::.:|.|.|                        ||   |.
 Worm   703 GQLVMNGTEDVPIVTRGQNGNTWRGIVAKPEGVLDVKNVVSEDASIGIWIDSQKVKIENG---QI 764

  Fly   720 LQPQLGGV--------------VELKEFNEA------------------YHATIPAYQFWT---- 748
            ::|.:.|:              |.::|.||:                  .:.......|.|    
 Worm   765 VRPAVHGIEITQNSNDVVDLGNVIIEEANESAIGVDERRDDLLIKNVKIQNGAGSGIDFMTPTGN 829

  Fly   749 LEFRNKHPAFIRFNFTLPWGAHFAVYSRRNVAPSVTQH-------DFVE--------FIKGGRLD 798
            :|.:|     |.......:|.|.:.:      ||...|       ..:|        .|.||.:.
 Worm   830 IELQN-----IEVKNMGGYGIHISEF------PSSPLHAVLLDNVSVIEQKRGHAGILISGGWIQ 883

  Fly   799 SHLRHRRSSANATTTGQDMELYRQDKDQSAESAQDQDSE-----------------QDESRSFDS 846
            :...|.....:...:...:.|...|.::.....::...|                 |.|...:||
 Worm   884 NVGMHNLKFKDNAVSSLIVALECNDGNEKLIKMENSTFERNTDIVQHIQLGSCANLQMEKNRYDS 948

  Fly   847 SESYDVETPL-------DTAKQHLQRIGKPQSHWVNKRSAGDGLPALDVDAMTVNVSLLQYLDTG 904
            :....:.:.|       :..|..:..|.|      |..:...|:..:.||   .|:....:.|..
 Worm   949 NNIDGIGSTLVITSENNEKKKNGVMEIVK------NNFTNNGGIYTVTVD---TNLHDAYFTDNN 1004

  Fly   905 L---------WFISVYNDELVAHSV------------------------SLLAEEA--------E 928
            |         ..||..|.::|.::.                        :.|.|:|        |
 Worm  1005 LKGNENSGAVLKISGENVKIVTNNFDNKDSKYQIGYSDDSPIDATFNEWNGLDEDAVLKTIDAKE 1069

  Fly   929 G------------------------VSTTCPND----------CSGRGSCYLGKCDCIDGYQGVD 959
            |                        |..|.|:.          ||.||:|..|.|.|..||.|.|
 Worm  1070 GSVLVVPYGSSTITTDNQIDALTTVVPVTVPDSLNIKCAHLAYCSRRGTCKEGICICPHGYTGFD 1134

  Fly   960 CSKSVCPVLCSAHGHYGGGVCH------CEEGWKGAECDIPVGECEVPNCSSHGRCIE-GECHCE 1017
            ||   .|:.|:..|:   |:|:      |.:||.|::|.||  .| :.||:.||:||: ..|.|:
 Worm  1135 CS---IPLFCNCSGN---GLCNLLNICLCNDGWSGSDCSIP--RC-LTNCTGHGKCIQPNSCECD 1190

  Fly  1018 RGWKGPYCDQHDCLDPLCSGHGTC-VAGQCYCKAGWQGEDCGTIDQQVYQCLPGCSEHGTYDLET 1081
            .||.|..|....|:|..|: ||.| ..|.|.|:.||||..|     |:..| ..||.:|.. ...
 Worm  1191 AGWMGETCSVTSCIDSQCT-HGHCGTNGLCKCEDGWQGSRC-----QIPLC-NSCSLNGIC-TRP 1247

  Fly  1082 GQCVCERHWTGPDCSQAV------CSLDCGRNGVCE--SGKCRCNSGWTGNLCDQLPCDSRCSEH 1138
            |.|.|...:.|.|||:.|      |..|| .:|:||  :..|.|..||.|..||           
 Worm  1248 GFCSCFEDYGGSDCSKCVGDSCEACDFDC-NHGICEPLTKTCSCAKGWMGGACD----------- 1300

  Fly  1139 GQCKNGTCVCSQGWNGRHCTLPGCENGCS----RHGQCTLENGEYRCDCIEGWAGRDCSIALELN 1199
                    |||.|         .|||...    :.....||                     ::|
 Worm  1301 --------VCSIG---------KCENSSQIYYIQPPTAELE---------------------DVN 1327

  Fly  1200 CKDNIDNDGDGMTDCSDSECCS--------HPACSEHIMCLSSNDPVEVLLRKQPPSVTASFYQR 1256
            ...|:..:|..:|: ::|..|:        |...|..|.|     |:       |.::|..   |
 Worm  1328 TVVNVFGEGFPITN-NNSYICTFGRTSVTGHRVSSALIRC-----PI-------PSNLTLG---R 1376

  Fly  1257 VKFLIEENSVQSYAHMDEYSENLFWSSFTPCRVSVMRGQ-----VITPQG-LGIV--GIRVSVDR 1313
            ..|.:.:..:.|.....| .:.:.::.:..|..|:.:|.     .|.||| .||.  .|.|....
 Worm  1377 HVFGVSQPGLLSAIGNSE-PKPIHFTLYDGCEPSLCQGSCVGPLCICPQGKTGIFCDVIEVLPTI 1440

  Fly  1314 DSRFGFTLTRQ-------GGWFDVLVNGGGAVTLQFQRSPFRPLTRTVFVPWNRIVVLP------ 1365
            |.||   |..|       |..:.:::....:..|:...|    :....|:....||..|      
 Worm  1441 DKRF---LEHQKANTAYEGVPYVLMLPTMASSVLRVNSS----IPNLNFIASKGIVAWPEPIGSP 1498

  Fly  1366 -PVQMQL---SDDDETT-SRNIKVAPLNPALTFLNSIHYHTADEANDASKVCMDHDHEKLRPQLI 1425
             |.::.:   |...||| |.||.|.|                :.|.:...|.:|....||:.:||
 Worm  1499 DPYEVSVTAFSPAGETTISWNITVQP----------------EYAVEVQNVTVDGGKAKLKGKLI 1547

  Fly  1426 STWMPNG--------------------------------VGAMPG-KRVIFAETQIVQESIQ--- 1454
            .....:.                                :..:|| ..|..|...:..:|||   
 Worm  1548 GPAAASSRKNPVVIRVRRDDIVDEILAESDTFGDVNFEYIPMLPGIYEVTMAHPNVPTDSIQPIR 1612

  Fly  1455 --IPGSDLHLTYQSSQASGYLSI-VRMRLTGETIPPTLTHVHVGVEIEGALHVKTY--------- 1507
              ||..:|.:..:||.:|..|.| .|.....:.|.|.:.:|.  ||..|:..:..:         
 Worm  1613 FTIPDLNLPIIGESSNSSLTLDISQREDCEVKVIQPKVDNVK--VEQHGSQRIVNFGRFWDGEVL 1675

  Fly  1508 ------------------EADPSLVHT----FAWNKRNVYRQKVY-------------------- 1530
                              ::..||:.|    ..:...|:|..||:                    
 Worm  1676 ATVMCGDVPMEIVRAPPIQSSGSLLTTPQVLSLYGNENLYEVKVHWDPEMTFNPSVTASDSSFDE 1740

  Fly  1531 -----------GVTVARISVGYQHSTCQ----------SPVWIAQTAKLQGYDVDISDIGGWGLD 1574
                       .:|.:.:.....:.|.|          .|.:.|...|.|.|...|.        
 Worm  1741 TPVTIPEEQYLRMTFSTVGESIGNGTIQVKDGENLMATIPYFYADANKSQYYTFKIC-------- 1797

  Fly  1575 IHHHYNFHEGILQKGDGSTLHMKEYPRTVKVVMGTGLQRPLTCPDYCNGVAKDAKLLTPIALATG 1639
            :...::..||.|...:.:|:.::...:.|.|.. |.::..:...|:                   
 Worm  1798 VRDEWDGQEGRLASTEVATIAIQNTQKGVDVTK-TNIRLNVQWADF------------------- 1842

  Fly  1640 PDGSLYVGDFNLVRRITPDGKVYTILQLSATQVSYQYYLAVS-----PADGHLYISDPERHQI-L 1698
               ||..|.:||:.|......|..:::||....|:...:..|     |.....:.:||....: :
 Worm  1843 ---SLQPGTYNLLVRSELHEPVEEVIELSPLNTSFCVPMISSRSRNLPTIHCSHFTDPASCDVAV 1904

  Fly  1699 RLVRLEKVKDPSINSDP--VVGSGQRCIPGDEGNCGDGGPAL----LARLS-HPKGLAIAADRTM 1756
            ..|.....:.||.:.:|  |...||:.:....||. ||...|    :|.:: .|...:::.:.:.
 Worm  1905 TSVASPDNQLPSFHFEPSVVTKKGQKILVTPRGNL-DGTIGLWNSEIAGITVTPSKRSVSLNESF 1968

  Fly  1757 YIADG--------TNIRAVDPKGVIHTLIGHHGHHNHWSPAPCSGTLMANQAQLQWP----TGLA 1809
            :|...        .|::.:                      |.....:.|::|.:.|    :.:.
 Worm  1969 WITFSWKDHNLIKCNVKTI----------------------PVHFVFLPNESQSEVPVHSSSNIL 2011

  Fly  1810 LSPLDGSLHFID--DRLVLRLTSDMKIRVVAGTPLHCSNGGQ-------------DGRVNKTGAD 1859
            :...|......|  ::.::..||.:.:       .:|.:|.:             .|..||...|
 Worm  2012 IRQKDDGNEICDSKNQPIVPATSTLVM-------CNCGDGARTRCREKYHSATACGGSWNKIADD 2069

  Fly  1860 ----NVLGTVLAMAF-------------------------------------------SPFGNLY 1877
                .|:.:.|||.|                                           :|||.:.
 Worm  2070 TVSLEVVASFLAMVFECREVSVDFAELRRSLECVASIESDCPINSRRRKREDVQMQNDAPFGIIN 2134

  Fly  1878 IADSDSRR---------VNSIRV----------------------VDTAGNMRYFAG----KQEG 1907
            ..::|..:         |.:||:                      :|.....|:...    ..||
 Worm  2135 SINTDFGKVLPVLNALDVQTIRISSVFIEFVDQIQKIFPEEIMSLLDKDAVDRFLGAIADQSDEG 2199

  Fly  1908 TGSQTCDCAIGGGSNGSATNSGVGGAGGSAYSTTVNPTRPNGGTTPTTPSGGNGNGNGNGSSATS 1972
            ......:..|.|.|..|..         ..::.||...:  .|..||..:|.:........:|..
 Worm  2200 LMISEAERRIIGSSASSLI---------QLWNLTVKSWK--SGKVPTERTGISHQDAKQLVAAAD 2253

  Fly  1973 SGGSVGGSNGSGGGANGGACICAG--------GIALSTGTGSSS--------------------G 2009
            ...|:...|    .|.....:..|        |:...|....|:                    .
 Worm  2254 KIKSISRQN----VAQDPFAMLHGYMERILETGLTEQTECAMSTVFIDKTEIEEDGQLRIHVYIK 2314

  Fly  2010 SNGGGTLASI-VGSGGLMSTGPTTTTTVLLGAKTTAAGIGAATLNDDGT-------------LSN 2060
            :....||.:| |....|.|...|.|.....|...:|   |.|:||..||             :.:
 Worm  2315 NRANMTLTNIAVRLSFLKSDSKTPTVNFNTGPSWSA---GVASLNGLGTFETGSSFEIHWTRILS 2376

  Fly  2061 AETLLSSNARFQ-----------------------------AISAIAVAQDGVINVADQG-SLHV 2095
            |...|::.|::|                             .|.||.:.:|.:...|... |:..
 Worm  2377 APRRLTTVAKYQPIVVFSFSIMGRLTQQKLFAPEISVIPKKTIRAINIIKDDLSPKAGTNFSIIS 2441

  Fly  2096 LALEH-YLP-------SHDENGEFHIPFPPSSEIYVFNRYGQHVAT-KDLT--SGKTRYSFLYSK 2149
            ..:.| |.|       ..|...|..:. |...||:|..:..|...| |.||  ||.|:...|..|
 Worm  2442 AIINHGYTPLKNVEIIMDDLKHEGSVT-PRLDEIFVNGKETQKTLTPKFLTIPSGSTQIIRLILK 2505

  Fly  2150 N-------------------------------------TSFGRLSTVTDASGN------------ 2165
            :                                     :.||.|....:.|..            
 Worm  2506 DRDDGIVTISSMNLTCLENEKLLPLETTETYAIRAVGISDFGMLLATPNQSAPLFFFRPTAAQMV 2570

  Fly  2166 ---KIQFLRDYSNVVSSIENTQDHKSEI-----------------------QINGIGIMTKLSEK 2204
               |::||.     :..|.:|..::...                       ::|.:..:..:.::
 Worm  2571 NVIKLEFLS-----IQQINSTDSNRKSFVAAFRNPESSSFGGALWARMPVPEVNAMNKLISIVDR 2630

  Fly  2205 G------RQEIE-LDYDSNTGLLN----SRSSGGETYIY-----------------QYDEFG-RV 2240
            |      .|.:| ...::|..:||    ...|..:...|                 |:|:.. |:
 Worm  2631 GGPRPRELQAVEWTSEENNNEMLNWIDPGPVSSAQQMFYELQFSNPDASTPEDENPQFDQLQFRI 2695

  Fly  2241 ---TGMILPSGEIVRITSQLADSQGLTVYVHA-------SVES----LF--SRERIAGEANELLV 2289
               ...|.|..||.:|  :....:.||.:::.       ||:|    :|  |.:.::.|....:|
 Worm  2696 EIPQTNIAPETEIGQI--EATSPEDLTYFLYTPDNNRRFSVDSENGRIFYDSDDPLSNEQEYCVV 2758

  Fly  2290 LGG----VRST----FLKRGQAHADAELKANNTL--VIHGDNGVVVEASAVARHPLLEAALPVE- 2343
            |..    .|||    .:..|....|..|.:.|.|  :||..:.:........|..|.....|.. 
 Worm  2759 LEARDPQGRSTRVPVAINNGGQRRDCMLFSTNNLTPMIHFGDYIPAPTILTPRTFLFTTTQPTSR 2823

  Fly  2344 ---------------------AEMLAMWSHQSVTMGEGLTNSMYSVYSLVGDVRNPQQTLNREIW 2387
                                 :|.....|.|:|:..:| |.||:             ||.....|
 Worm  2824 VTPDTTRITDFYTRTTSSGTTSETSTSTSSQTVSETDG-TTSMF-------------QTSEPSTW 2874

  Fly  2388 ------VNQSRVIGVEFDQFTNRETFYDARRTPILIVAYDQSGLPKSYYPTNGYPVNITYDRFNR 2446
                  .::...:.:|...:.|.:               ..|..|.|..|..|...:.|......
 Worm  2875 QTSNEPTSEPTTVPLETSTWQNTD---------------GTSMEPTSVTPEEGQTTSPTATTLTF 2924

  Fly  2447 VEGW--------AWGPAELKYSYDRHGLLSEITSQQDG--------------IVSFVYNDWN-LV 2488
            |:..        |...:|...|.:..|..|..||:.:|              |.|.|.:... ::
 Worm  2925 VDSTLETVTTTEATTTSEGTTSQEDFGTTSMTTSESEGTSPEYITSEATLEPITSTVESTTTIMI 2989

  Fly  2489 SEIG-LASQRKFVLQYDDAGGLRHVVLPSGTRHSFSMQTSIGFI--------------RCTYTPP 2538
            |.|. |.|...:..|..|:..:..::..:.|..|.:..|..||.              ..|.|.|
 Worm  2990 STISELISTSDYTTQSSDSTSMEPIMSSTSTFESSAFPTPDGFTLEPITTTMTTEYPDGTTMTSP 3054

  Fly  2539 GSTRAYL-----QHYSHAGALLQT-------ILPGDGAR-IVYRYNAAGQLTEVVHGDGRSEFQY 2590
            .:|...|     ::|:.....:.:       |||.|... :....:...:|...|..||..|   
 Worm  3055 DATLPILTTTSSEYYTSTQESIASSTSEVTIILPTDSTTFLTPPPSTTTELIYTVSSDGTLE--- 3116

  Fly  2591 NEATGMPSTV 2600
             ..|..|:|:
 Worm  3117 -PITSAPTTI 3125

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ten-aNP_001162732.2 EGF_2 934..960 CDD:285248 12/35 (34%)
Keratin_B2 998..1162 CDD:279797 57/173 (33%)
EGF_2 <1003..1025 CDD:285248 10/22 (45%)
EGF_2 1032..1057 CDD:285248 12/25 (48%)
EGF_2 <1071..1095 CDD:285248 7/23 (30%)
EGF_2 1101..1126 CDD:285248 10/26 (38%)
EGF_2 <1135..1157 CDD:285248 4/21 (19%)
EGF_CA 1163..1192 CDD:238011 4/32 (13%)
NHL 1622..1927 CDD:302697 64/426 (15%)
NHL repeat 1675..1721 CDD:271320 9/53 (17%)
NHL repeat 1745..1787 CDD:271320 3/49 (6%)
NHL repeat 1802..1847 CDD:271320 6/50 (12%)
NHL repeat 1864..1897 CDD:271320 12/106 (11%)
RHS_repeat 2213..2250 CDD:283287 10/61 (16%)
RhsA 2397..2958 CDD:225750 49/255 (19%)
Rhs_assc_core 2939..3015 CDD:274730
Tox-GHH 3274..3349 CDD:292269
T01D3.1NP_001256538.1 Beta_helix 276..417 CDD:289971 31/213 (15%)
Beta_helix 392..544 CDD:289971 32/209 (15%)
Beta_helix <739..848 CDD:289971 16/116 (14%)
Beta_helix 819..1004 CDD:289971 32/204 (16%)
EGF_2 <1143..1166 CDD:285248 7/25 (28%)
EGF_2 <1175..1198 CDD:285248 10/22 (45%)
DSL <1188..1230 CDD:302925 18/42 (43%)
EGF_2 1269..1299 CDD:285248 11/30 (37%)
Cadherin_repeat 2692..2776 CDD:206637 19/85 (22%)
DUF4758 2952..3130 CDD:292572 36/178 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11219
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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