Protein Alignment Ten-a and ten-1

DIOPT Version :10

• Sequence 1: NP_001162732.2
• Gene: Ten-a / 32183
• FlyBaseID: FBgn0267001
• Length: 3387
• Species: Drosophila melanogaster
• Sequence 2: NP_001254940.1
• Gene: ten-1 / 175953
• WormBaseID: WBGene00006498
• Length: 2837
• Species: Caenorhabditis elegans
• Alignment Length: 3464
• Identity: 785/3464 - (22%)
• Similarity: 1280/3464 - (36%)
• Gaps: 965/3464 - (27%)

  Fly   134 HHEEATPLGDGTPTVTAAAPEVTYAQPHQQRSTMPAGSPLKVSTVSAGKYQSNANLGLFPNSSSS 198
            |.:||.|       :.|||     |.....::|.....|..:||::..|::..|  ...|:.|..
 Worm    93 HRKEAAP-------ILAAA-----AMLDNSKATTSTAQPSIMSTLTKDKHKEPA--PPLPHPSEC 143

  Fly   199 GGSSVQNGVTAHTPRSTNPFLNGSTKFASDDGGLENINMLKPSASSSTAASSSIRSSHRNRNALN 263
            |...|.........|:||.           .|...|..|.:|.|......||   ..|...|...
 Worm   144 GQPCVSGQSQMFQHRTTNA-----------QGPPPNRPMPRPPAGMPMMTSS---HEHDYTNDYE 194

  Fly   264 RLSGMTSSSSDSQTHHHQQQQQQQQQQQQQQQQQQLQISQQQQQQIAAVKQQQQMLPPEDSGDDD 328
            ....|..|..:..::|...:.....|........::.:|||::.|    :.||.|.||
 Worm   195 DPEEMARSRGEGFSNHLLIKTTPPPQPHPNFNSYEMSMSQQRRSQ----QHQQPMAPP------- 248

  Fly   329 FVLGLGSLELGNCSSGGESEEPPPEPAPPEIPPRTQSLLMSLRKHSD--YKLKYEEKGDQKHEEF 391
                     |.:|...|..:..                  .|.|::|  |
 Worm   249 ---------LSDCWGSGVHDSG------------------VLHKNADGAY--------------- 271

  Fly   392 IPTSQLQKDYILSDNLR-SDQQLKPIS-------PGDSNGLGGHPQQMPQSMSTGSNTIGHGGID 448
                     ||.|.:|| :...|.|.|       |..|   ||.|.   .:.|..|.|:
 Worm   272 ---------YIPSGSLRTTSSTLSPASGQRYLDQPHTS---GGAPN---PTYSDASTTL------ 315

  Fly   449 RGGVGLPMGAGTMPGGVGGGPGGVAGGGPQVGVGPPGSGNGGNCQISGSQPLVMPGFPLRNSHSA 513
               :..|:.|||.........|.:..|.|..| ||.....
 Worm   316 ---LKYPLAAGTNQNRRRQQVGTMNNGDPVAG-GPMALSK------------------------- 351

  Fly   514 HAPHYSPYSPSRFHIDKRCQHRCS-----WKCLSIALIFVSVVLTAMLAYFAAVSSMKPNMDSTN 573
                    ...:|..|   ...||     |..|..|.:.|::.:..:|.:.|      ||.
 Worm   352 --------KKKKFDDD---SDTCSRWPSKWNILLAAALLVALFVICILLFRA------PNY---- 395

  Fly   574 CILVQDVKSQPHDLRGGLAKSNEKGVATAFPTEESIQTSTSDHGQNGHGLMNPSAGSGGSNSGIQ 638
                  |.:||       |.|::               :||            ||.:..|.   .
 Worm   396 ------VYTQP-------APSSD---------------ATS------------SAAAAASR---Y 417

  Fly   639 QQLLLQQQQPHSINQPLTPLDATNTHLQDHHQLTYGGALPGGVGGIGMSGGGIMNGGLNGGLGGQ 703
            |.|.|:                               |||..:
 Worm   418 QDLGLR-------------------------------ALPPAI---------------------- 429

  Fly   704 LMQQPGGGLNGHHHQALQPQLGGVVELKEFNEAYHATIPAYQFWTLEFRNKHPAFIRFNFTLPWG 768
                               .||..|:::.|.::...|         |.....|:.||||.|:..|
 Worm   430 -------------------SLGERVDVEFFPKSMATT---------ELTVTKPSRIRFNATVGSG 466

  Fly   769 AHFAVYSRRNVAPSVTQHDFVEFIKGGRLDSHLRHRRSSANATTTGQDMELYRQDKDQSAESAQD 833
            |...:.....|.||::.||.:..|:..|:                        :|........::
 Worm   467 AQLVLLMSAGVHPSLSLHDALFPIRADRI------------------------RDSKSPTHIVEE 507

  Fly   834 QDSEQDESRSFDSSESYDVETPLDTAKQHLQRIGKPQSHWVNKRSAGDGLPALDVDAMTVNVSLL 898
            ..|....|....||...::|.                   ::.|||                :..
 Worm   508 FGSRSRRSLGASSSRHRNIEI-------------------LSPRSA----------------TFE 537

  Fly   899 QYLDTGLWFISVYNDELVAHSVSLLAEEAEGVST---------------------TCPNDCSGRG 942
            |::..|..:::..|:......:|.:|||.:..:|                     .|.::|:.||
 Worm   538 QFVLEGRHYLTFINERSRVEPISFVAEELQRPTTPPKTSSSGTSGAKEHPLASVLVCESNCNQRG 602

  Fly   943 SCYLGKCDCIDGYQGVDCSKSVCPVLCSAHGHYGGGVCHCEEGWKGAECDIPVGECEVPNCSSHG 1007
            .|..|||.|..|:.|..|.::||||:||.:|.:.||:|.|:.|:||.||::....|||.:|:..|
 Worm   603 ECVHGKCHCAPGFTGRTCDEAVCPVVCSGNGVFSGGICVCKSGFKGKECEMRHNWCEVADCNGRG 667

  Fly  1008 RC-IEGECHCERGWKGPYCDQHDCLDPLCSGHGTCVAGQCYCKAGWQGEDCGTIDQQVY------ 1065
            || .:|.|.|..||.|..|:...|....|...|.||.|.|||..||:|.||......:.
 Worm   668 RCDTDGRCRCNPGWTGEACELRACPHASCHDRGVCVNGTCYCMDGWRGNDCSVFADAIVHVPQAQ 732

  Fly  1066 ------------------QCLP-----------------------------GCSEHGTYDLETGQ 1083
                              |..|                             .||.||  .|....
 Worm   733 SPPRRGQEPTESSKTRKAQVKPTPTSEKKKESRELQKPIIATVQVPTESSHPCSAHG--QLIDDI 795

  Fly  1084 CVCERHWTGPDCSQAVCSLDCGRNGVC-ESGKCRCNSGWTGNLCDQLPCDSRCSEHGQC-KNGTC 1146
            |.||..|...||||..|  .| .||.| :.|.|:|..||.|:.|....|...|.:.|:| .:|:|
 Worm   796 CQCESGWDSVDCSQQAC--QC-VNGDCLDDGSCQCWKGWRGSNCTDKKCAIGCEDRGKCASDGSC 857

  Fly  1147 VCSQGWNGRHCTLPGCENGCSRHGQCTLE--NGEYRCDCIEGWAGRDCSIALELNCKDNIDNDGD 1209
            .||.||||.:|.:.||.|.||..|:|.::  :.|:.|.|..|..|.|||:::|::|.|.:|||.|
 Worm   858 KCSSGWNGENCAIDGCPNQCSGKGECGMDRRSSEWSCRCQAGSTGVDCSVSVEMHCDDGLDNDSD 922

  Fly  1210 GMTDCSDSECCSHPACSEHIMCLSSNDPVEVLLRKQPPSVTASFYQRVKFLIEENSVQSYAHMDE 1274
            |:.||.|.||||..:||...:|.::..|:|||:| .||...|:|.|||.|||.|.|||||....:
 Worm   923 GLIDCDDPECCSSSSCSSESVCSTAASPIEVLMR-MPPIFNANFAQRVGFLIMEKSVQSYTDSSQ 986

  Fly  1275 YSENLFWSSFTPCRVSVMRGQVI---TPQG------------LGIVGIRVSVDRDSRFGFTLTRQ 1324
            ::|||         :||:||:|:   :|.|            :.:||:|||......:||||||:
 Worm   987 FNENL---------ISVIRGRVMWGGSPTGSDDLSTYSNKSTVPLVGVRVSDAAHPLYGFTLTRE 1042

  Fly  1325 GGWFDVLVNGGGAVTLQFQRSPFRPLTRTVFVPWNRIVVLPPVQMQLSDDDETTSRNIKVAPLN- 1388
            .|:||:.|||..:|||||.|:.|:.:.::|||...:|:.:..:.:.........:  |.:||..
 Worm  1043 DGYFDLTVNGARSVTLQFLRTQFQSVKKSVFVSPRQIIHIDDIVLYRQSGGSPPA--ISMAPARA 1105

  Fly  1389 ---------PALTFLNSIHYHT----ADEANDASKVCMDHDHEKLRPQLISTWMPNGVGAMPGKR 1440
                     |.:..:::..|.:    .||.:|:|::.:|                        .|
 Worm  1106 KCSPTLRRIPDVVLISNWQYTSDGIETDETSDSSRIVVD------------------------SR 1146

  Fly  1441 VIFAETQIVQESIQIPGSDLHLTYQSSQASGYLSIVRMRLTGETIPPTLTHVHVGVEIEGALHVK 1505
            .||       ||:.|.|:|:.|.|.|:::....|.:.:.|..:.:...|..||:.:.|.|....:
 Worm  1147 SIF-------ESLPIQGTDVRLVYDSARSPAAPSTMLIGLLYDRVDKELRKVHINIRIAGRRFDR 1204

  Fly  1506 TYEADPSLVHTFAWNKRNVYRQKVYGVTVARISVGYQHSTC---QSPVWIAQTAKLQGYDVDISD 1567
            ......:|.:.|||:|.|.|||...|:....:.|||::..|   ...||..:.:::.|.... ..
 Worm  1205 VLAPRTNLTYVFAWDKMNAYRQSESGLVPVTVRVGYEYQGCDRTSERVWQTRRSQMMGATAR-KM 1268

  Fly  1568 IGG-WGLDIHHHYNFHEGILQKGDGSTLHMKEYPRTVKVVMG-TGLQRPLTCPDYCNGVAKDAKL 1630
            ||. |.||||||.:....:::.|:|....:.|....|....| .|::|.:.|.. |.|......|
 Worm  1269 IGTMWTLDIHHHLDIVNNVVEMGNGGYRLITESEPRVSTFAGLDGVKRDVECLK-CEGKVDSISL 1332

  Fly  1631 LTPIALATGPDGSLYVGDFNLVRRITPDGKVYTILQLSATQVSYQYYLAVSPADGHLYISDPERH 1695
            ..|..:....||||.:||.|::||::.||:|.|||.|.....|:.||:||||.||.:.||.|...
 Worm  1333 FRPTTVVYAQDGSLIIGDHNMIRRVSQDGQVSTILTLGLADTSHSYYIAVSPVDGTIAISLPLHK 1397

  Fly  1696 QILRLVRLEKVKDPSINSDPVVGSGQRCIPGDEGNCGDGGPALLARLSHPKGLAIAADRTMYIAD 1760
            |:.|:..||. :|...|.|.:.|.|..|....: :||||..|..|:|..|||::......:|:||
 Worm  1398 QVWRISSLEP-QDSRNNYDVLAGDGTVCASAVD-SCGDGALAQNAQLIFPKGISFDKMGNLYLAD 1460

  Fly  1761 GTNIRAVDPKGVIHTLIGHHGHHNHWSP-APCSGTLMANQAQLQWPTGLALSPLDGSLHFIDDRL 1824
            ...||.:|..|.|.: ||......|  | ..|:........|::|||.|.:.|:.||:..:|..:
 Worm  1461 SRRIRVIDTTGHIRS-IGETTPDQH--PIRTCAQITKLVDLQMEWPTSLTIDPITGSVLVLDTNV 1522

  Fly  1825 V--LRLTSDMKIRVVAGTPLHCSNGGQDGRVNKTGAD---NVLGTVLAMAFSPFGNLYIADSDSR 1884
            |  :.:..|: :.:..|:|..|.........:....|   :::.....:.....|.:|:.:||.|
 Worm  1523 VYEIDVVHDV-VTIALGSPTTCDLANATSSASAKSLDHRRHLIQNARDITVGTDGAIYVVESDGR 1586

  Fly  1885 RVNSIRVVDT-AGNMRYFAGKQEGTGSQTCDCAIGGGSNGSATNSGVGGAGGSAYSTTVNPTRPN 1948
            |:|.:|.:.: ........|     |...|.|.:
 Worm  1587 RLNQVRKLSSDRSTFSILTG-----GKSPCSCDV------------------------------- 1615

  Fly  1949 GGTTPTTPSGGNGNGNGNGSSATSSGGSVGGSNGSGGGANGGACICAGGIALSTGTGSSSGSNGG 2013
                                                     .||.|...::|
 Worm  1616 -----------------------------------------AACGCDDAVSL------------- 1626

  Fly  2014 GTLASIVGSGGLMSTGPTTTTTVLLGAKTTAAGIGAATLNDDGTLSNAETLLSSNARFQAISAIA 2078
                                                            ..:.:|.|...:..|:.
 Worm  1627 ------------------------------------------------RDVAASQAHLSSPYAVC 1643

  Fly  2079 VAQDGVINVADQGSLHVLALEHYLPSHD-ENGEFHIPFPPSSEIYVFNRYGQHVATKDLTSGKTR 2142
            |:..|.:.:||.|:..:..:...:..:| .:..:.:......|.|.|||:|||.:|..|.:|:|.
 Worm  1644 VSPSGDVIIADSGNSKIKKVSARMAKYDGRSRTYEVTDAERQEKYTFNRHGQHSSTVSLITGRTF 1708

  Fly  2143 YSFLYSKNTSFGRLSTVTDASGNKIQFLRDYSNVVSSIENTQDHKSEIQINGI-GIMTKLSEK-- 2204
            ::|.|..::....:|.:..|||..::.|: .::.:..:|.|...::.:.::.. |.:.::|::
 Worm  1709 FNFSYQVDSPISMISEIRAASGVVLRVLK-RNDSLFDLETTLGQRTTLTMSAYDGTLEQVSKRDS 1772

  Fly  2205 --GRQEIELDYDSNTGLLNSRSSGGETYIYQYDEFGRVTGMILPSGEIVRITSQLADSQGLTVYV 2267
              .|...:|.|  ..|||.||........::|||:||..|:
 Worm  1773 ATSRDATKLFY--KKGLLTSRIDVATAVGFEYDEYGRAIGL------------------------ 1811

  Fly  2268 HASVESLFSRER---IAGEANELLVLGGVRSTFLKRGQAHADAELKANNTLVIHGDNGVVVEASA 2329
                    .|:|   ..||  |.:.:|.|.:..|..||......|...| |.:|..||......:
 Worm  1812 --------KRDREYWRLGE--ETISMGSVNTEVLLNGQRFQQVRLGEGN-LAVHSTNGATTRLIS 1865

  Fly  2330 VARHPLLEAALPVEAEMLAMWSHQSV--TMGEGLTNSMYSVYSLVGDVRNPQQTLNREI-----W 2387
            : |:.....|.|:....|...| .|:  :.||.|.:...:....:|   |||:   ||:     |
 Worm  1866 L-RNEGYSLASPLGTSTLYDKS-SSIPDSNGEPLISRRRTKVPAIG---NPQR---RELTTRWDW 1922

  Fly  2388 ---------------------VNQSRVIGVEFDQFTNRETFY------DARRTPILIVAYDQSG- 2424
                                 :|...:..:|:|..:|::|..      ||:  .:|.:.|..||
 Worm  1923 RHVARRGDDSDGSLGRRKVAEINGVNMFSMEYDVKSNQDTLRLGSTTDDAQ--ALLFIDYTSSGR 1985

  Fly  2425 LPKSYYPTNGY--PVNITYDRFNRVEGWAWGPAELKYSYDRHGLLSEITSQQDGI---VSFVYND 2484
            :.:...|.:..  .:|||:|...|.....||..:::.:||....|:|  ...||.   :...|..
 Worm  1986 IRRISAPEDSQMAEMNITWDGAGRKSEVTWGSWKIRLTYDNSNRLTE--HAIDGARVPIKMSYAG 2048

  Fly  2485 WNLVSEIGLASQR---------KFVLQYDDAGGLRHVVLPSGTRHSFS------------MQTSI 2528
                     ||:|         |:.:|||:...::.|:..|....|||            .:||:
 Worm  2049 ---------ASRRPNEIQHDGAKWNIQYDNYDRIKEVISKSQEATSFSSIALGGDEWVLKRRTSL 2104

  Fly  2529 GFIRCTYTPPGSTRAYLQHYSHAGALLQTILPGDGARIVYRYN-AAGQLTEVVHGDGRSEFQYNE 2592
                       :::..|...|..|.:|::..|.:....:.|.: ..|:.||:::.:..:......
 Worm  2105 -----------NSKPSLVRLSREGKVLESTTPDENHYWLERKDPITGRTTEILNDEETTVVTCWS 2158

  Fly  2593 ATGMPSTVSHTERELEYRWDFEYAAGLLAEERIDYVAKTGLS---NAKFSYEYDSQLRVVALQGR 2654
            ..|.|  :....|.|:.....:  ..|:|.:.:..:..|...   .:.|:||||..|||..:|..
 Worm  2159 PEGAP--MCSRSRNLQENTTMQ--GHLVARKSVTIMTPTSSEPSITSSFTYEYDDMLRVTTIQPV 2219

  Fly  2655 IGGQSLPTQAFAYDPRTGRPSLIGQFRFSQPAQ-NQTQLHDGTASFTRTVDGR--------FQTQ 2710
            |....|.:...:||.|.|..:.|..|::::.|. ::.|.|......::..|.|        |...
 Worm  2220 IEQSVLESIQLSYDERRGHVAAINGFKWARDASTSRCQGHGLMYETSKANDHRQVVERKLIFGDA 2284

  Fly  2711 RMALAIHRLEVFRMEFSYGVHGRISQTRTYTRNMAVNSYTNVKNYTWDCDGQLVGVEA--QEPWG 2773
            |.::.|.|.:..|...|   |..||.:.| .||..:..       |:|..|::..||.  |||..
 Worm  2285 RASIKIIRDKAGRASES---HLEISSSGT-QRNQKITR-------TFDAAGRVASVEQNDQEPVR 2338

  Fly  2774 FRYDDNGNLLSLTYRGNTIPMEYNAQDRIVKFGEGQYKYDARGLVAQNAREERFHYNTQGLLVRA 2838
            ..::.:..:..:    |...:|:|....:..|.:..|:.|:.|.|.:......|.|:.:|.||.|
 Worm  2339 IIWNSDARVEKI----NDRVVEWNRGGALKTFQDISYQVDSIGWVVKRDNTTVFGYDGKGRLVSA 2399

  Fly  2839 SKRGRFDVRYYYDHLKRLTTRKDNFGNVTQFFYTNQQRPYEVSQIYSPRDGKLMSLTYDDVGHLI 2903
             :..:..:..:||...|: .:..|..:...|:|.....|..||  :..::||:.:|.||| ..:.
 Worm  2400 -RSSQLRINIFYDREDRV-VQIQNSKDFIHFYYGYIDTPKLVS--HFSKNGKISTLFYDD-DSVP 2459

  Fly  2904 YAQVYRH--KYYVATDQSGTPLMLFNQYGEGIREIMRSPFGHIV-YDSNPYLYLPIDFCGGI-LD 2964
            :|.....  :|.:.||::.|...:... ...:|.|.||.||.:: ..|:.:.:|||.:.||| :.
 Worm  2460 FAMQSDDGTRYALLTDETSTIKAIIGD-SNVLRIIDRSVFGALLPSSSSSHPFLPIGYLGGIEIS 2523

  Fly  2965 QVTTLVHMGDGRVYDPLIGQWMSPDWQRVAERIITP---TRLHL-YRFNGN----------DPIN 3015
            :::..: :.:||..|....::||          |:|   .||.| .:|:.:          .|..
 Worm  2524 EISVSI-LNNGRPLDLYSERYMS----------ISPEAVVRLELNEKFSNSIDLMALEIDRQPFR 2577

  Fly  3016 VGHERHYPEDFAAWMRTLGYNVGNLVPQLARDLWQPPALWGRPPANPVALNLRRPFDNIPTMAVE 3080
            |   .:.||||..|     :::..|.|.|.     |.|..|.|.::.:...|...|.
 Worm  2578 V---ENVPEDFETW-----FSLAGLSPNLL-----PSAHLGLPASSAIVHRLLSSFP-------- 2621

  Fly  3081 SGFLAHLNVRRMSDFEQLSA--PPRSALKCDVMDPSPKTIGSDTEPPFGKGIVVSRTA-DGQAIV 3142
                     |::.....|:.  |.|.|....:..|:.:|..|..:..|...::::..| .|:.:|
 Worm  2622 ---------RKLRPLTHLTTVLPTRLASDISLTSPTSETSWSIDDVGFSNLLILNEDATTGEVMV 2677

  Fly  3143 SSVPAANAIYRDVYTSVFNRSKLLPFTFVVHNAQQDSFFFV-KEDAWRATEDRQQLKRLQGQVNT 3206
            ..:....:..|:|.:.:|:..|.|.|.         ::..| ....|||...:.:|.      :|
 Worm  2678 EMLSDLKSEEREVISKLFDGVKSLDFA---------TWGLVPTRHLWRAPNSKLELS------ST 2727

  Fly  3207 TFHEITREATVGSGPAGAANGGAGSSSSSSSSSGGGSSSNTGNYLDVKIHGAHAIINLRYGTTVA 3271
            :|...|......|                                 |::....:.|.:.:....|
 Worm  2728 SFSHFTMAVNKDS---------------------------------VELRNGKSKIVVHFSENKA 2759

  Fly  3272 KEQQRLMHHAKLTAVRKAWHREKEALRSGLTTALEWSQQETDEILKQSYANNYEGEYIHDVNLYP 3336
            :..::::...|.......|..|::...:|..|..:||.:||.|:..:...:.|      |:.:.|
 Worm  2760 EIVKKIVEELKTRENIAVWRAERKRAEAGEKTWRQWSDRETRELTSKGSVSGY------DIEMKP 2818

  Fly  3337 E----LAEDPYNIKFVKKK 3351
            .    |....::.||.|.:
 Worm  2819 AHQSGLLASVHSWKFRKSE 2837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ten-a	NP_001162732.2	acid_disulf_rpt	1199..1225	CDD:411265	14/25 (56%)
		NHL	1622..1927	CDD:302697	91/311 (29%)
		NHL repeat	1675..1721	CDD:271320	19/45 (42%)
		NHL repeat	1745..1787	CDD:271320	14/41 (34%)
		NHL repeat	1802..1847	CDD:271320	13/46 (28%)
		NHL repeat	1864..1897	CDD:271320	8/33 (24%)
		RHS_core	<2118..>2248	CDD:469161	37/134 (28%)
		RhsA	<2366..3015	CDD:442442	164/740 (22%)
		Tox-GHH	3272..3349	CDD:464783	16/80 (20%)
		EGF_2	937..960	CDD:400365	10/22 (45%)
		EGF_2	1003..1025	CDD:400365	10/22 (45%)
		EGF_2	1034..1057	CDD:400365	11/22 (50%)
		C_rich_MXAN6577	<1035..1146	CDD:469225	45/165 (27%)
		EGF_CA	1163..1192	CDD:238011	10/30 (33%)
ten-1	NP_001254940.1	C_rich_MXAN6577	<594..702	CDD:469225	45/107 (42%)
		EGF_2	598..620	CDD:400365	10/21 (48%)
		EGF_2	662..686	CDD:400365	10/23 (43%)
		EGF_Tenascin	691..719	CDD:480934	13/27 (48%)
		acid_disulf_rpt	913..>930	CDD:411265	9/16 (56%)
		NHL	1305..1663	CDD:302697	109/502 (22%)
		NHL repeat	1335..1372	CDD:271323	17/36 (47%)
		NHL repeat	1445..1476	CDD:271323	11/31 (35%)
		NHL repeat	1492..1540	CDD:271323	12/48 (25%)
		RhsA	1532..2518	CDD:442442	240/1219 (20%)
		NHL repeat	1566..1600	CDD:271323	8/33 (24%)
		NHL repeat	1637..1663	CDD:271323	6/25 (24%)
		Tox-GHH	2763..2835	CDD:464783	16/77 (21%)