DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ten-a and Wif1

DIOPT Version :9

Sequence 1:	NP_001162732.2	Gene:	Ten-a / 32183	FlyBaseID:	FBgn0267001	Length:	3387	Species:	Drosophila melanogaster
Sequence 2:	XP_006241457.1	Gene:	Wif1 / 114557	RGDID:	619774	Length:	379	Species:	Rattus norvegicus

Alignment Length:	351	Identity:	92/351 - (26%)
Similarity:	131/351 - (37%)	Gaps:	97/351 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   867 GK--PQSHWVNKRSAGDGLPALDVDAMTVNVS--------------LLQYLDTGLW---FISVYN 912
            ||  |.:|  :.|.|...:||:.|:..::|.:              .|:.||.|:.   .::|..
  Rat    61 GKMAPFTH--DFRKAQQRMPAIPVNIHSMNFTWQASGQAEYFYEFLSLRSLDKGIMADPTVNVPR 123

  Fly   913 DELVAHSVSLLAEEAEGVSTTCPNDCSGRGSCYLGKCDCIDGYQ--GVDCSKSVCPVLCSAHGHY 975
            ...|.|..|::.     |...|           |||.|.:..::  .:..:....|:|.:.....
  Rat   124 LGTVPHKASVVQ-----VGFPC-----------LGKQDGVAAFEVNVIVMNSEGNPILRTPQNAI 172

  Fly   976 GGGVCHCEEGWKGAECDIPVGECEVPNCSSHGRCIEGE-CHCERGWKGPYCDQHDCLDPLCSGHG 1039
            ....|      :.|||  |.|      |.:.|.|.|.. |.|..|:.||:|::..|: |.|...|
  Rat   173 FFKTC------QQAEC--PGG------CRNGGFCNERRVCECPDGFYGPHCEKALCI-PRCMNGG 222

  Fly  1040 TCVAGQCYCKAGWQGEDCGTIDQQVYQCLPGCSEHGTYDLETGQCVCERHWTGPDCSQAVCSLDC 1104
            .||.                                     .|.|:|...:.|.:|.:|.||..|
  Rat   223 LCVT-------------------------------------PGFCICPPGFYGVNCDKANCSATC 250

  Fly  1105 GRNGVC-ESGKCRCNSGWTGNLCDQLPCDSRCSEHGQC-KNGTCVCSQGWNGRHCTLPGCENGCS 1167
            ...|.| ..|||.|..|..|..|:...|...|...|:| ....|.|.:|:.|..|:.|.||.||.
  Rat   251 FNGGTCFYPGKCICPPGLEGEQCELSKCPQPCRNGGKCIGKSKCKCPKGYQGDLCSKPVCEPGCG 315

  Fly  1168 RHGQCTLENGEYRCDCIEGWAGRDCS 1193
            .||.|...|   :|.|.|||.||.|:
  Rat   316 AHGTCHEPN---KCQCREGWHGRHCN 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ten-a	NP_001162732.2	EGF_2	934..960	CDD:285248	5/27 (19%)
		Keratin_B2	998..1162	CDD:279797	44/166 (27%)
		EGF_2	<1003..1025	CDD:285248	9/22 (41%)
		EGF_2	1032..1057	CDD:285248	5/24 (21%)
		EGF_2	<1071..1095	CDD:285248	4/23 (17%)
		EGF_2	1101..1126	CDD:285248	10/25 (40%)
		EGF_2	<1135..1157	CDD:285248	7/22 (32%)
		EGF_CA	1163..1192	CDD:238011	14/28 (50%)
		NHL	1622..1927	CDD:302697
		NHL repeat	1675..1721	CDD:271320
		NHL repeat	1745..1787	CDD:271320
		NHL repeat	1802..1847	CDD:271320
		NHL repeat	1864..1897	CDD:271320
		RHS_repeat	2213..2250	CDD:283287
		RhsA	2397..2958	CDD:225750
		Rhs_assc_core	2939..3015	CDD:274730
		Tox-GHH	3274..3349	CDD:292269
Wif1	XP_006241457.1	FlaF	<10..57	CDD:299725
Wif1	XP_006241457.1	WIF	35..179	CDD:295401	27/141 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1225
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810