DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ten-a and tnxba

DIOPT Version :9

Sequence 1:NP_001162732.2 Gene:Ten-a / 32183 FlyBaseID:FBgn0267001 Length:3387 Species:Drosophila melanogaster
Sequence 2:XP_021322558.1 Gene:tnxba / 100536295 ZFINID:ZDB-GENE-070103-5 Length:2285 Species:Danio rerio


Alignment Length:2217 Identity:382/2217 - (17%)
Similarity:627/2217 - (28%) Gaps:907/2217 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 SSSEDEYQNT----GQATAFDTQLLAQLLLQSQQLASMEH-YNSDCEPDYLRQRDRHHEEATPLG 142
            :|:.:...||    ..||..:|:|..|....|...:.:.| ..|...||....:.........:|
Zfish   631 NSTTESIVNTINVQNPATRLNTKLKDQTQSTSSTTSKVNHTLPSSTMPDVDTVKKPIQSLQNKIG 695

  Fly   143 DGTPTVTAAAPEVTYAQPHQQRSTMPAGSPLKV-------STVSAGKYQSNANLGLFP--NSSSS 198
            |...:.|.:.......|       .|..|.||.       ||.|..:..........|  ||..:
Zfish   696 DKKNSTTKSTVNTINIQ-------KPVTSLLKTKLKEQTQSTPSTSQVNQTLTTSTKPEVNSIQN 753

  Fly   199 GGSSVQNGVTAHTPRSTNPFLNGSTKFASDDGGLENINMLKPSAS----------SSTAASSSIR 253
            ...||||.|:.....:|...:|             .|.:.||..|          .||.::|.:.
Zfish   754 PVQSVQNTVSDKNNSTTKSTVN-------------TIKVQKPVTSLLKTKLKEKTQSTPSTSQVN 805

  Fly   254 SSHRN-------------RNALNRLSGMTSSSSDSQTHHHQQQQ---QQQQQQQQQQQQQQLQIS 302
            .:|..             ::..:.:||..:|::.|..:....|:   ...:.:.::|.|.....|
Zfish   806 QTHTTSTKPEVESIQNPVQSVQDTISGKKNSTTKSTVNTINVQKPVTSLLKTKLKEQTQSTPSTS 870

  Fly   303 QQQQQQIAAVKQQQQMLPPEDSGDDDFVLGLGSLELGNCSSGGESEEPPPEPAPPEIPPRTQSL- 366
            |..|...:::|       ||                      .:|.:.|.:.|...|..:|.|. 
Zfish   871 QVNQTLTSSIK-------PE----------------------VDSIQKPVQSAKNTIGDQTNSTT 906

  Fly   367 -----LMSLRKHSDYKLKYEEKGDQKHEEFIPTSQLQKDYILSDNLRSDQQLKPISPGDSNGLGG 426
                 :::::|.....||.::| ::.......|||:.:....|.....|...||:          
Zfish   907 KSTVNIINVKKPVTTLLKNKQK-ERTQSISSTTSQVNQTLPASTKSDVDSIQKPV---------- 960

  Fly   427 HPQQMPQSM-----STGSNTIGHGGIDRGGVGLPMGAGTMPGGVGGGPGGVAGGGPQVGVGPPGS 486
              |.:..::     ||..:|..|                                          
Zfish   961 --QSVQTTINDKKNSTTKSTDNH------------------------------------------ 981

  Fly   487 GNGGNCQISGSQPLVMPGFPLRNSHSAHAPHYSPYSPSRFHIDKRCQHRCSWKCLSIALIFVSVV 551
                   |...:|:   |..|:|.....|...|..:                          |::
Zfish   982 -------IIVQKPV---GTLLKNKMRIQALSNSTKN--------------------------SII 1010

  Fly   552 LTAMLAYFAAVSSMKPNMDSTNCILVQDVKSQPHDLRGGLAKSNEKGVATAFPTEESIQTSTSDH 616
            ....|       |.||.:|    ::.:.|...|                |.|..:.:..|....|
Zfish  1011 DQTSL-------SAKPAVD----VVQKSVSPSP----------------TTFGEKRNTTTKLVSH 1048

  Fly   617 GQNGHGLMNPSAGSGGSNSGIQQQLLLQQQQPHSINQPL--TPLDATNTHLQDHHQLTYGGALPG 679
            ..|.:       .|...|:.:|.|.:  ..:|..|||.|  ||..|.:..       |.|.||. 
Zfish  1049 NINVN-------ASKPENTKVQTQSV--SSKPTHINQTLLSTPKPAVDVK-------TPGSALQ- 1096

  Fly   680 GVGGIGMSGGGIMNGGLNGGLGGQLMQQPGGGLNGHHHQALQPQLGGVVELKEFNEAYHATIPAY 744
                 .:||   ........|..|.::..            .|.|..::.:|..|:.        
Zfish  1097 -----DISG---TKKNSTSKLTAQTIRNN------------VPTLTTLLNIKLKNQT-------- 1133

  Fly   745 QFWTLEFRNKHPAF---IRFNFTLPWGAHFAVYSRRNVAPSVTQHDFVEFIKGGRLDSHLRHRRS 806
                      ||:|   ...|.|:|:...|        ...||.    ...|...:.:.|:....
Zfish  1134 ----------HPSFSTISHVNQTVPFSTKF--------VDEVTH----RMKKNSTVKARLQTINI 1176

  Fly   807 SANATTTGQDMELYRQDKDQSAE-----SAQDQDSE--------------------QDESRSFDS 846
            :|:...|   ..|:.:.|:|:..     |..:|.|.                    :..|:|.|.
Zfish  1177 NASKPVT---TSLHTKTKNQTQSTSLKISKANQTSPSTTKPVEGEISLGKKKNFTVKSASQSIDV 1238

  Fly   847 SESYDVETPLDTAKQHLQRIGKPQSHWVNKRSAG--------DGLPALDVDAMTV---------- 893
            ..|..:.||.:|..::..   ||.|...|.....        ||...||:|.:..          
Zfish  1239 HASKPITTPPNTKTKNQT---KPSSSKNNNNDQAVTSTSPVMDGTQNLDIDKLAESSPIKIVITE 1300

  Fly   894 ------------NVSLLQ----YLDTGLWFISVYNDELV---------------AHSVSLLAEEA 927
                        |::.::    .|:.|...:..:...||               ...:.||.:|.
Zfish  1301 GCVQRKSQGDVGNITKIRETELSLNPGSPLVMTHRINLVQGTCNGGCETDMAALRERIELLEKEM 1365

  Fly   928 EGV--------STTCPNDCSGRGSCYLGKCDCIDGYQGVDCSKSVCPVLCSAHGHYGGGVCHCEE 984
            ..:        ...||.:|||:|.|..|||.|..|:.|.|||...||                  
Zfish  1366 SAIKQMCVPCSGEQCPKNCSGQGKCEEGKCVCFQGFSGPDCSSKACP------------------ 1412

  Fly   985 GWKGAECDIPVGECEVPNCSSHGRCIEGECHCERGWKGPYCDQHDCLDPLCSGHGTCVAGQCYCK 1049
                            .||:..|:|::|:|.|:.|:.|..|.:  .:|...:             
Zfish  1413 ----------------SNCNKKGKCVKGKCVCQTGFTGIGCSK--AIDERIT------------- 1446

  Fly  1050 AGWQGEDCGTIDQQVYQCLPGCS------EHGTYDLETGQCVCERHWT-------GPDCS-QAVC 1100
                 ....|:..::...:|...      :......||...|.::|.|       .|..| ..|.
Zfish  1447 -----VTVETVTMKMSSAMPDTKTVKTRPDKAILVKETVTKVPKKHTTAKPTVKPSPTASTDKVL 1506

  Fly  1101 SLDCGRNGVCESGKCRCNSGWTGNLCDQLPCDSRCSEHGQCKNGTCVCSQGWNGRHCTLPGCENG 1165
            |...|::.:              .:..|.....:..|  |.|..|.|...|              
Zfish  1507 SHTTGKDNI--------------KIVGQQSESMKLQE--QTKGKTTVIKMG-------------- 1541

  Fly  1166 CSRHGQCTLENGEYRCDCIEGWAGRDCSIALELNCKDNIDNDGDGMTDCSDSECCSHPACSE--- 1227
                                                    :|....||.||.   ||.|..|   
Zfish  1542 ----------------------------------------SDNQAQTDLSDK---SHNAKDEPAY 1563

  Fly  1228 ----HIMCLSSNDPVEVL--LRKQPPSVTAS-----------------------------FYQRV 1257
                ......||...::|  |.|...:||.|                             |:..|
Zfish  1564 QNVTQRSVKKSNGTSKILHNLFKGSMNVTRSKTKITTRTAGDQGEESKTNAVSAEKDEKLFHGNV 1628

  Fly  1258 KFLIEEN---------SVQSYAHMDEYSENLFWSSFTPCRVSVMRGQVITPQGLGIVGIRVSVDR 1313
            ..:..|.         ||:|.|||..:|:                    |...|.::| .|.|..
Zfish  1629 TTVQAEKKSDKPEIDASVESKAHMKHFSK--------------------TSSRLSVIG-SVEVHN 1672

  Fly  1314 DSRFGFTLTRQGGWFDVLVNGGGAVTLQFQRSPFRPLTRTVFVPWNRIVVLPPVQMQLSDDDETT 1378
            .:..||.::    |             :..|..|:..|.|              :.::...:|.:
Zfish  1673 ITSTGFIMS----W-------------EAHRDKFKNFTVT--------------RREIKAGNEDS 1706

  Fly  1379 SR------NIKVAP---LNPALTFLNSIHYHTADEANDASK-------VCMDHDHEKLRPQ---L 1424
            .:      |:..|.   .|..||.:.|    :..|.|...|       ....:..:.|:||   .
Zfish  1707 EKIHEAIENVTDAERLGSNRTLTKILS----SKSEGNAMKKFSQILAGTTRSYHFKGLQPQTQYA 1767

  Fly  1425 ISTWMPNGVGAMPGKRVIFAETQIVQESIQI---PGSDL---HLTYQSSQAS------------- 1470
            ||.:     |:.||.|     ::|.:.::..   |.:||   ::|..|...|             
Zfish  1768 ISLF-----GSGPGMR-----SKIHRITLSTGPEPPTDLVFSNITETSFSLSWAKPKSIVAEFKV 1822

  Fly  1471 GYLSIVRMRLTGE----TIPPTLTHVHVGVEIEGALH-------VKTYEADPSLVHTFAWNKRNV 1524
            .|::.|    |||    ::...|:||.:.....|..:       :...|::| ::.:......:.
Zfish  1823 KYINTV----TGESGSMSVDSQLSHVLLSKLTAGTTYDITVSSVLDKLESEP-VIASITTVPDSP 1882

  Fly  1525 YRQKVYGVTVARISVGYQHSTCQSPVWIAQTAKLQGY--------------DVDISDIGGWGLDI 1575
            ...||..:|..:..:          ||....||:..|              .|.:|     |..:
Zfish  1883 TELKVVNITDTKALL----------VWKPSKAKVDSYILSYGTTKSPNVTITVTLS-----GSSV 1932

  Fly  1576 HHHYNFHEGILQKGDGSTLHMKEYPRTVKVVMGTGLQRPLTCPDYCNGVAKDAKLLTPIALATGP 1640
            .|.       |:....|:|:|.:....|..:..:.:....|                     ||.
Zfish  1933 EHQ-------LRALHRSSLYMVKMTSQVNRLQSSSVSTSFT---------------------TGS 1969

  Fly  1641 DGSLYVGDFNLVRRITPDGKVY--TILQLSATQVSYQYYLAVSPADGHLYISDPERHQILRLVRL 1703
            ...|.|        :|||...:  .::...|.:|:::.|...              :|:...|: 
Zfish  1970 GVKLQV--------VTPDEVTFHSAVISWKAPRVAFKSYRLT--------------YQLSEEVK- 2011

  Fly  1704 EKVKDPSINSDPVVGSGQRCIPGDEGNCGDGGPALLARLSHPKGLAIAADRTMYI---ADGTNIR 1765
            |.:.:||:....:.                             |||..::.|:.|   .||..|.
Zfish  2012 ELILNPSVTHYELT-----------------------------GLAAFSNYTVKIDGERDGQYIS 2047

  Fly  1766 AVDPKGVIHTLIGHHGHHNHWSPAPCS-----GTLMANQAQLQWPTGLALSP------------- 1812
            .|........|       .|..|..||     |...:.:|:: :|.|....|             
Zfish  2048 FVSSDFTTAQL-------PHPYPTDCSEVQINGMKESGEAEI-YPEGKNGEPVRVYCDMETDGGA 2104

  Fly  1813 -------LDGSLHF-------------------IDDRLVLRLTS--DMKIRVVAGTPLHCSNGGQ 1849
                   :|||..|                   :.:.::..|||  .|.:|:..           
Zfish  2105 WTVFQRRMDGSTDFFRSWRDYSKGFGLLSGEFWLGNDVLHTLTSLKAMSLRIDL----------- 2158

  Fly  1850 DGRVNKTGADNVLGTVLAMAFSPFGNLYIADSDSRRVNSIRVVDTAG-NMRYFAGKQEGTGSQTC 1913
                 ::|.|......:....|...|.|..|...       ...||| :|:|..|:...|..:..
Zfish  2159 -----RSGNDTAFAQYINFNISSEANHYAIDLSG-------YSGTAGDSMKYHKGRPFSTKDKDP 2211

  Fly  1914 D-----CA---IGG---------GSNG----SATNSGV-----GGAGGSAYSTTVNPTRPN--GG 1950
            |     ||   :||         ..||    .:.|.||     .|...|...|.:. .||:  ..
Zfish  2212 DTLSIHCAKAYMGGWWYKNCYKANLNGLYASYSDNKGVVWIDWKGKDASLPFTEMK-LRPSNFSQ 2275

  Fly  1951 TTPTTPS 1957
            ||.|||:
Zfish  2276 TTSTTPT 2282

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ten-aNP_001162732.2 EGF_2 934..960 CDD:285248 13/25 (52%)
Keratin_B2 998..1162 CDD:279797 30/177 (17%)
EGF_2 <1003..1025 CDD:285248 8/21 (38%)
EGF_2 1032..1057 CDD:285248 1/24 (4%)
EGF_2 <1071..1095 CDD:285248 6/36 (17%)
EGF_2 1101..1126 CDD:285248 2/24 (8%)
EGF_2 <1135..1157 CDD:285248 6/21 (29%)
EGF_CA 1163..1192 CDD:238011 0/28 (0%)
NHL 1622..1927 CDD:302697 63/377 (17%)
NHL repeat 1675..1721 CDD:271320 6/45 (13%)
NHL repeat 1745..1787 CDD:271320 11/44 (25%)
NHL repeat 1802..1847 CDD:271320 12/85 (14%)
NHL repeat 1864..1897 CDD:271320 7/33 (21%)
RHS_repeat 2213..2250 CDD:283287
RhsA 2397..2958 CDD:225750
Rhs_assc_core 2939..3015 CDD:274730
Tox-GHH 3274..3349 CDD:292269
tnxbaXP_021322558.1 COG3942 596..>913 CDD:332523 61/330 (18%)
EGF_2 1380..1406 CDD:285248 13/25 (52%)
fn3 1792..1870 CDD:306538 16/81 (20%)
fn3 1880..1952 CDD:306538 16/93 (17%)
fn3 1976..2037 CDD:306538 15/104 (14%)
FReD 2061..2270 CDD:238040 43/233 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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