DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1924 and CNE1

DIOPT Version :9

Sequence 1:	NP_572788.2	Gene:	CG1924 / 32180	FlyBaseID:	FBgn0030377	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_009343.1	Gene:	CNE1 / 851241	SGDID:	S000000054	Length:	502	Species:	Saccharomyces cerevisiae

Alignment Length:	478	Identity:	140/478 - (29%)
Similarity:	215/478 - (44%)	Gaps:	73/478 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 FADHFD---DMEASTRRWVLSQAKKDDIADEISK-YDGIWNWEPPQRMVWANDLGLVLKSKAKHA 130
            |.:||.   :.:...:.|:.|:|    :.:|.|| |...|.....:....|.|.|:.:::....|
Yeast    33 FWEHFQAYTNTKHLNQEWITSEA----VNNEGSKIYGAQWRLSQGRLQGSAWDKGIAVRTGNAAA 93

  Fly   131 AIAAHLHQPFDFKSEKPLVVQYEITIQKGQECGGSYLKLLSAGKETEQLQTF-NDKTPYTIMFGP 194
            .|...|..|.:......|||||||.:.....|||:::||:|.....|.|:.: .|.....::|||
Yeast    94 MIGHLLETPINVSETDTLVVQYEIKLDNSLTCGGAFIKLMSGFMNVEALKHYAPDTEGVELVFGP 158

  Fly   195 DKCGKDVT-IHFIFKHVNPINGTITEKHCNKPNNSFEEPFKDKL-----PHLYQLVV-RPDNSFE 252
            |.|..::. :.|....|:.|.      |.:|.....|.|. .||     .|||.|:: ....||:
Yeast   159 DYCAPEINGVQFAINKVDKIT------HESKLRYLQEMPL-SKLTDTSQSHLYTLIIDESAQSFQ 216

  Fly   253 IRIDHKIIK-----EGSLLTDFKPPVNPPAEIDDPNDHKPDSWDEREKIPDPTVHKPEDWDENET 312
            |.||.|.:.     |.....:|:||:.||..|.|.:..||..||:|.:||||...|..|.||.:.
Yeast   217 ILIDGKTVMVREHIEDKKKVNFEPPITPPLMIPDVSVAKPHDWDDRIRIPDPEAVKLSDRDERDP 281

  Fly   313 LKLPDAD-------------MIFDPTATKPEDWDDEIDGEWQAPMVDNPVCKKDQTC-----GII 359
            |.:|..|             .|.||.|.||..|.:...|||..||:.||:|..::.|     |:|
Yeast   282 LMIPHPDGTEPPEWNSSIPEYILDPNAQKPSWWKELEHGEWIPPMIKNPLCTAERGCGQQIPGLI 346

  Fly   360 RNPNYKGKWIAPMIDNPNYQGKWAPRKIANPDFFEDLKPFQM-TPISAVGLELWSMSSDILFDNL 423
            .|..|||......|.||||.|:|.|.:|.||.::|:..|.:: ..||.|.||.||.|.::|..|:
Yeast   347 NNAKYKGPGELNEIINPNYMGEWHPPEIENPLYYEEQHPLRIENVISGVILEFWSGSPNMLISNI 411

  Fly   424 IITDDVEVA------------RDFAANSFDIKRRYI-------------DRERDSIVNKVVELVK 463
            .:..:|..|            |.|..:....:|:::             :||..:..:::::.:.
Yeast   412 YVGKNVTEAQIIGNKTWLMRDRAFRGSDGPTERKFMNSRLGNLQTTFHNERESPNPFDRIIDRIL 476

  Fly   464 DYPSIWAIGLVAIVALVALTKCC 486
            :.|..:.: ..|:|.|.....||
Yeast   477 EQPLKFVL-TAAVVLLTTSVLCC 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1924	NP_572788.2	Calreticulin	70..425	CDD:278680	127/390 (33%)
CNE1	NP_009343.1	Calreticulin	33..413	CDD:395201	127/390 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343261
Domainoid	1	1.000	201	1.000	Domainoid score	I558
eggNOG	1	0.900	-	-		E1_KOG0675
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	203	1.000	Inparanoid score	I842
Isobase	1	0.950	-	0	Normalized mean entropy	S1196
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001260
OrthoInspector	1	1.000	-	-		otm46798
orthoMCL	1	0.900	-	-		OOG6_102144
Panther	1	1.100	-	-	O	PTHR11073
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X875
TreeFam	1	0.960	-	-
	13	12.700