DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1924 and CALR

DIOPT Version :9

Sequence 1:	NP_572788.2	Gene:	CG1924 / 32180	FlyBaseID:	FBgn0030377	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_004334.1	Gene:	CALR / 811	HGNCID:	1455	Length:	417	Species:	Homo sapiens

Alignment Length:	454	Identity:	145/454 - (31%)
Similarity:	220/454 - (48%)	Gaps:	92/454 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 HFADHFDDMEASTRRWVLSQAKKDDIADEISKY---DGIWNWEPPQRMVWANDLGLVLKSKAKHA 130
            :|.:.|.|.:..|.||:.|:.|.|     ..|:   .|.:..:..:      |.||.....|:..
Human    22 YFKEQFLDGDGWTSRWIESKHKSD-----FGKFVLSSGKFYGDEEK------DKGLQTSQDARFY 75

  Fly   131 AIAAHLHQPFDFKSEKPLVVQYEITIQKGQECGGSYLKLLSAGKETEQLQTFNDKTPYTIMFGPD 195
            |::|.. :||..|.: .||||:.:..::..:|||.|:||..  ...:|.....| :.|.||||||
Human    76 ALSASF-EPFSNKGQ-TLVVQFTVKHEQNIDCGGGYVKLFP--NSLDQTDMHGD-SEYNIMFGPD 135

  Fly   196 KCG---KDVTIHFIFKHVNP-INGTITEKHCNKPNNSFEEPFKDKLPHLYQLVVRPDNSFEIRID 256
            .||   |.|.:.|.:|..|. ||..|..|             .|:..|||.|:|||||::|::||
Human   136 ICGPGTKKVHVIFNYKGKNVLINKDIRCK-------------DDEFTHLYTLIVRPDNTYEVKID 187

  Fly   257 HKIIKEGSLLTDFKPPVNPPAEIDDPNDHKPDSWDEREKIPDPTVHKPEDWDENETLKLPDADMI 321
            :..::.|||..|:  ...||.:|.||:..||:.||||.||.|||..||||||:.|.:.
Human   188 NSQVESGSLEDDW--DFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDKPEHIP------- 243

  Fly   322 FDPTATKPEDWDDEIDGEWQAPMVDNPVCKKDQTCGIIRNPNYKGKWIAPMIDNPNYQGKWAPRK 386
             ||.|.||||||:|:||||:.|              :|:||.|||:|....||||:|:|.|...:
Human   244 -DPDAKKPEDWDEEMDGEWEPP--------------VIQNPEYKGEWKPRQIDNPDYKGTWIHPE 293

  Fly   387 IANPDFFEDLKPFQMTPISAVGLELWSMSSDILFDNLIITDDVEVARDFAANSFDI----KRRYI 447
            |.||::..|...:.......:||:||.:.|..:|||.:||:|...|.:|...::.:    :::..
Human   294 IDNPEYSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMK 358

  Fly   448 DRERDSIVNKVVELVKDYPSIWAIGLVAIVALVALTKCCRFGTTKIQESAAAESKKTDDPQPHE 511
            |::.:.  .::.|..:|                          .|.:|...||.|:.|:.:..:
Human   359 DKQDEE--QRLKEEEED--------------------------KKRKEEEEAEDKEDDEDKDED 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1924	NP_572788.2	Calreticulin	70..425	CDD:278680	131/361 (36%)
CALR	NP_004334.1	N-domain	18..197		65/203 (32%)
		Calreticulin	23..332	CDD:395201	131/361 (36%)
		4 X approximate repeats	191..255		35/73 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..278		49/108 (45%)
		P-domain	198..308		57/133 (43%)
		Interaction with PPIB. /evidence=ECO:0000250	237..270		19/54 (35%)
		3 X approximate repeats	259..297		19/51 (37%)
		C-domain	309..417		22/114 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..417		9/73 (12%)
		Prevents secretion from ER	414..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1196
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860