DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1924 and Clgn

DIOPT Version :9

Sequence 1:	NP_572788.2	Gene:	CG1924 / 32180	FlyBaseID:	FBgn0030377	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_006255360.1	Gene:	Clgn / 685504	RGDID:	1592643	Length:	612	Species:	Rattus norvegicus

Alignment Length:	574	Identity:	247/574 - (43%)
Similarity:	331/574 - (57%)	Gaps:	66/574 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LLLSAVKA--IDSDLEWDDF-EDVDVEDVQQEDVDEKPTYKSPVIDAKKFHFADHFDDMEASTRR 83
            ||....||  :|..:|.:|| |..|..|.:.|.......||:|. ...:.:|.:.||....|  .
  Rat    12 LLFITAKADFVDDGVEVEDFSESSDESDFKDEPSSGTIKYKTPQ-PIGEVYFTETFDSGNLS--G 73

  Fly    84 WVLSQAKKDDIADEISKYDGIWNWEPPQRMVWANDLGLVLKSKAKHAAIAAHLHQPFDFKSEKPL 148
            ||||:|||||:..|||.|||.|..|..:......|.||||||||||.||:|.|.:||.| ::|||
  Rat    74 WVLSKAKKDDMDSEISIYDGRWEIEELKENQVPGDRGLVLKSKAKHHAISAVLEKPFIF-ADKPL 137

  Fly   149 VVQYEITIQKGQECGGSYLKLLSAGKETEQ--LQTFNDKTPYTIMFGPDKCGKDVTIHFIFKHVN 211
            :||||:..|.|.:|||:|:|||:   :|..  |:.|.|||.|||||||||||:|..:|.||:|.:
  Rat   138 IVQYEVNFQDGIDCGGAYVKLLA---DTGDLILENFYDKTSYTIMFGPDKCGEDYKLHLIFRHKH 199

  Fly   212 PINGTITEKHCNKPNNSFEEPFKDKLPHLYQLVVRPDNSFEIRIDHKIIKEGSLLTDFKPPVNPP 276
            |..|...|||...|:...:|.|.|:..|||.||:.||::|||.||.|::.:|:||.|..||:|||
  Rat   200 PKTGVFEEKHAKPPDVDLKEFFTDRKTHLYTLVMNPDDTFEILIDQKVVNQGTLLEDVVPPINPP 264

  Fly   277 AEIDDPNDHKPDSWDEREKIPDPTVHKPEDWDENETLKLPDAD-------------MIFDPTATK 328
            .|||||||.||:.||:|.||||||..|||||||.|.:::.|..             .|.:|.|.|
  Rat   265 REIDDPNDRKPEEWDDRAKIPDPTAVKPEDWDEKEPIQIEDPSAVKPDGWLDDEPKFIPNPKAEK 329

  Fly   329 PEDWDDEIDGEWQAPMVDNPVCKKDQTCG-----IIRNPNYKGKWIAPMIDNPNYQGKWAPRKIA 388
            ||||.|.:||||:||.:.||.|:..  ||     :|.||.|||.|..|||:||||||.|:|:||.
  Rat   330 PEDWSDSMDGEWEAPHIPNPACQIG--CGEWKPPMIDNPKYKGIWRPPMINNPNYQGIWSPQKIP 392

  Fly   389 NPDFFEDLKPFQMTPISAVGLELWSMSSDILFDNLIITDDVEVARDFAANSFDIKRRYIDRERDS 453
            |||:|||..||.:|..||:|||||||:.||.|||.||..:.|||..:||:.:::|....:.....
  Rat   393 NPDYFEDDHPFLLTSFSALGLELWSMTPDIYFDNFIICSEKEVADQWAADGWELKIMVANANEPG 457

  Fly   454 IVNKVVELVKDYPSIWAIGLV-AIVALVALTKCCRFGTTKIQESAAAESKKTDDPQPHEPRPWGS 517
            ::.::....::.|.:|.:.|| |.:.:..:|..|                            |..
  Rat   458 VLRQLTTAAEERPWLWLMYLVMAGLPIALVTSFC----------------------------WPR 494

  Fly   518 RMSRAKKWKLTIPPRRAYSCPLPPKKKLDDNEWKFKAAKKQKHTQ--TKESNTE 569
            ::.  ||:: .|.|::|..|.||.|..|:....:.||.:|.:..|  .|.|.||
  Rat   495 KVK--KKYE-DIGPKKADLCQLPSKAALEQEPEEEKAPEKPEDLQEEKKPSETE 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1924	NP_572788.2	Calreticulin	70..425	CDD:278680	198/374 (53%)
Clgn	XP_006255360.1	Calreticulin	62..429	CDD:395201	198/374 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339330
Domainoid	1	1.000	502	1.000	Domainoid score	I328
eggNOG	1	0.900	-	-		E1_KOG0675
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	561	1.000	Inparanoid score	I1053
OMA	1	1.010	-	-		QHG48587
OrthoDB	1	1.010	-	-		D230478at33208
OrthoFinder	1	1.000	-	-		FOG0001260
OrthoInspector	1	1.000	-	-		mtm9095
orthoMCL	1	0.900	-	-		OOG6_102144
Panther	1	1.100	-	-	O	PTHR11073
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X875
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770