DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1924 and canx

DIOPT Version :9

Sequence 1:	NP_572788.2	Gene:	CG1924 / 32180	FlyBaseID:	FBgn0030377	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_998613.1	Gene:	canx / 406757	ZFINID:	ZDB-GENE-040426-2797	Length:	600	Species:	Danio rerio

Alignment Length:	534	Identity:	265/534 - (49%)
Similarity:	344/534 - (64%)	Gaps:	45/534 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ATLSMLFASSLLLLSAVKAIDSDLEWDDFE-DVD--VEDVQQEDVDEKP------------TYKS 60
            |.||:  :..|||:..|:|  .:.|.||.| ||:  ::|:|:||::|:.            |||:
Zfish    10 ALLSL--SLCLLLMGPVRA--QEEEADDMEMDVEDAIDDMQEEDIEEEEQKAPAPPSAPTVTYKA 70

  Fly    61 PVIDAKKFHFADHFDDMEASTRRWVLSQAKKDDIADEISKYDGIWNWEPPQRMVWANDLGLVLKS 125
            |. ...:.:||:.||  :.:.:.|||||||||.|.::|:||||.|..|..|......|.||||||
Zfish    71 PE-PMGEHYFAEAFD--KGTLQGWVLSQAKKDGIDEDIAKYDGKWEVEEMQDSKLPGDKGLVLKS 132

  Fly   126 KAKHAAIAAHLHQPFDFKSEKPLVVQYEITIQKGQECGGSYLKLLSAGKETEQLQTFNDKTPYTI 190
            ||||.||:|.|.:||.|.: |||:||||:..|.|.:|||:|:||||...:.: |:.|.|||||||
Zfish   133 KAKHHAISALLLRPFTFDT-KPLIVQYEVNFQTGIDCGGAYVKLLSQTPDLD-LEEFVDKTPYTI 195

  Fly   191 MFGPDKCGKDVTIHFIFKHVNPINGTITEKHCNKPNNSFEEPFKDKLPHLYQLVVRPDNSFEIRI 255
            ||||||||:|..:||||:|.||..|...|||..||::.....:.||..|||.||:.|||:|||.|
Zfish   196 MFGPDKCGEDYKLHFIFRHKNPKTGEFEEKHAKKPDSDLRSYYTDKKTHLYTLVLNPDNTFEILI 260

  Fly   256 DHKIIKEGSLLTDFKPPVNPPAEIDDPNDHKPDSWDEREKIPDPTVHKPEDWDENETLKLPDAD- 319
            |..::..||||.|..|||||||||:||:||||:.||||.||.||...|||||||:...|:.|.|
Zfish   261 DQTVVNSGSLLNDVTPPVNPPAEIEDPDDHKPEDWDERPKIQDPDAVKPEDWDEDAPAKIADEDA 325

  Fly   320 ------------MIFDPTATKPEDWDDEIDGEWQAPMVDNPVCKKDQTCG-----IIRNPNYKGK 367
                        .|.||.|.||||||:::||||:||.:.||||:....||     :|.|||||||
Zfish   326 VKPDGWLDDEPEYISDPDAVKPEDWDEDMDGEWEAPQIPNPVCETAPGCGAWERPMIDNPNYKGK 390

  Fly   368 WIAPMIDNPNYQGKWAPRKIANPDFFEDLKPFQMTPISAVGLELWSMSSDILFDNLIITDDVEVA 432
            |.:||||||||||.|.||||.||||||||.||:|||.||||||||||||||.|||..||.|..||
Zfish   391 WKSPMIDNPNYQGVWKPRKIPNPDFFEDLHPFRMTPFSAVGLELWSMSSDIFFDNFFITSDRNVA 455

  Fly   433 RDFAANSFDIKRRYIDRERDSIVNKVVELVKDYPSIWAIGL--VAIVALVALTKCCRFGTTKIQE 495
            ..:|.:.:.:|:.........:||:::...::.|.:|.:.:  ||:..::.:..||. |......
Zfish   456 ERWANDGWGLKKAAEGAAEPGLVNQMITAAEERPWLWIVYVLTVALPLVLIIVFCCT-GKKSSAS 519

  Fly   496 SAAAESKKTDDPQP 509
            :.||:.||||:|||
Zfish   520 TPAAKYKKTDEPQP 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1924	NP_572788.2	Calreticulin	70..425	CDD:278680	217/372 (58%)
canx	NP_998613.1	Calreticulin	79..448	CDD:278680	217/372 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579033
Domainoid	1	1.000	518	1.000	Domainoid score	I295
eggNOG	1	0.900	-	-		E1_KOG0675
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1324
Inparanoid	1	1.050	586	1.000	Inparanoid score	I960
OMA	1	1.010	-	-		QHG48587
OrthoDB	1	1.010	-	-		D230478at33208
OrthoFinder	1	1.000	-	-		FOG0001260
OrthoInspector	1	1.000	-	-		mtm6387
orthoMCL	1	0.900	-	-		OOG6_102144
Panther	1	1.100	-	-	O	PTHR11073
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X875
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.770