DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1924 and Clgn

DIOPT Version :9

Sequence 1:	NP_572788.2	Gene:	CG1924 / 32180	FlyBaseID:	FBgn0030377	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_011246598.1	Gene:	Clgn / 12745	MGIID:	107472	Length:	615	Species:	Mus musculus

Alignment Length:	597	Identity:	243/597 - (40%)
Similarity:	343/597 - (57%)	Gaps:	69/597 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LLLSAVKA--IDSDLEWDDF-EDVDVEDVQQEDVDEKPTYKSPVIDAKKFHFADHFDDMEASTRR 83
            ||...|.|  :|..:|.:|| |:.|..:::.|.......||:|. ...:.:|.:.||  ..:...
Mouse    16 LLFITVNADFMDDGVEVEDFSENSDESNIKDEPSSGTFKYKTPQ-PIGEVYFTETFD--SGNLAG 77

  Fly    84 WVLSQAKKDDIADEISKYDGIWNWEPPQRMVWANDLGLVLKSKAKHAAIAAHLHQPFDFKSEKPL 148
            ||||:|||||:..||:.|||.|..|..:......|.||||||||||.||||.|.:||.| ::|||
Mouse    78 WVLSKAKKDDMDSEIAIYDGRWEIEELKENQVPGDRGLVLKSKAKHHAIAAVLEKPFIF-ADKPL 141

  Fly   149 VVQYEITIQKGQECGGSYLKLLSAGKETEQ--LQTFNDKTPYTIMFGPDKCGKDVTIHFIFKHVN 211
            :||||:..|.|.:|||:|:|||:   :|..  |:.|.|||.|||||||||||:|..:|.||:|.:
Mouse   142 IVQYEVNFQDGIDCGGAYIKLLA---DTGDLILENFYDKTSYTIMFGPDKCGEDYKLHLIFRHKH 203

  Fly   212 PINGTITEKHCNKPNNSFEEPFKDKLPHLYQLVVRPDNSFEIRIDHKIIKEGSLLTDFKPPVNPP 276
            |..|...|||...|:...:|.|.|:..|||.||:.||::||:.||.|::.:|:||.|..||:|||
Mouse   204 PKTGVFEEKHAKPPDVDLKEFFTDRKTHLYTLVMNPDDTFEVLIDQKVVNQGTLLDDVVPPINPP 268

  Fly   277 AEIDDPNDHKPDSWDEREKIPDPTVHKPEDWDENETLKLPDAD-------------MIFDPTATK 328
            .|||||:|.||:.||:|.||||||..:||||||||..::.|:.             .|.:|.|.|
Mouse   269 REIDDPSDKKPEEWDDRAKIPDPTAVRPEDWDENEPAQIEDSSAVKPDGWLDDEPKFIPNPKAEK 333

  Fly   329 PEDWDDEIDGEWQAPMVDNPVCKKDQTCG-----IIRNPNYKGKWIAPMIDNPNYQGKWAPRKIA 388
            ||||.|::||||:||.:.||.|:..  ||     :|.||.|||.|..|||:||||||.|:|:||.
Mouse   334 PEDWSDDMDGEWEAPHIPNPACQIG--CGEWKPPMIDNPKYKGIWRPPMINNPNYQGLWSPQKIP 396

  Fly   389 NPDFFEDLKPFQMTPISAVGLELWSMSSDILFDNLIITDDVEVARDFAANSFDIKRRYIDRERDS 453
            |||:|||..||.:|..||:|||||||:.||.|||.||..:.|||..:|.:.:::|....:.....
Mouse   397 NPDYFEDDHPFLLTSFSALGLELWSMTPDIYFDNFIICSEKEVADQWATDGWELKIMVANANEPG 461

  Fly   454 IVNKVVELVKDYPSIWAIGLVAI---VALVA------------------LTKCCRFGTTKIQESA 497
            ::.::|...::.|.:|.:.||..   |||||                  .|:.|     |:|..|
Mouse   462 VLRQLVIAAEERPWLWLMYLVMAGLPVALVASFCWPRKVKKKYEDTGPKKTELC-----KLQSKA 521

  Fly   498 AAESKKTDDPQPHEP-------RPWGSRMSRAKKWKLTIPPRRAYSCPLPPKKKLDDNEWKFKAA 555
            |.|.:..::..|.:|       :|..:.:...:|..:..|..::..    .::.|:..|...|.:
Mouse   522 ALEQEAEEEKAPEKPEDVQEEKKPGEAEVVTVEKEVIGEPEEKSKE----DRETLEGQEEVSKLS 582

  Fly   556 KKQKHTQTKESN 567
            |.....:.|:::
Mouse   583 KSGSEDEMKDAD 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1924	NP_572788.2	Calreticulin	70..425	CDD:278680	195/374 (52%)
Clgn	XP_011246598.1	Calreticulin	66..433	CDD:365986	195/374 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835702
Domainoid	1	1.000	502	1.000	Domainoid score	I343
eggNOG	1	0.900	-	-		E1_KOG0675
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	561	1.000	Inparanoid score	I1087
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001260
OrthoInspector	1	1.000	-	-		mtm8849
orthoMCL	1	0.900	-	-		OOG6_102144
Panther	1	1.100	-	-	O	PTHR11073
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X875
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760