DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1924 and Canx

DIOPT Version :9

Sequence 1:NP_572788.2 Gene:CG1924 / 32180 FlyBaseID:FBgn0030377 Length:570 Species:Drosophila melanogaster
Sequence 2:NP_001103969.1 Gene:Canx / 12330 MGIID:88261 Length:591 Species:Mus musculus


Alignment Length:585 Identity:268/585 - (45%)
Similarity:348/585 - (59%) Gaps:72/585 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 LLLL--SAVKAIDS------DLEWDDFEDV--DVEDVQ-QEDVDEKP----TYKSPVIDAKKFHF 70
            ||:|  :||:|.|.      |:| ||.:||  :|||.: :.|....|    |||:|| ...:.:|
Mouse    10 LLVLGTAAVEAHDGHDDDAIDIE-DDLDDVIEEVEDSKSKSDASTPPSPKVTYKAPV-PTGEVYF 72

  Fly    71 ADHFDDMEASTRRWVLSQAKKDDIADEISKYDGIWNWEPPQRMVWANDLGLVLKSKAKHAAIAAH 135
            ||.||  ..|...|:||:|||||..|||:||||.|..:..:......|.||||.|:|||.||:|.
Mouse    73 ADSFD--RGSLSGWILSKAKKDDTDDEIAKYDGKWEVDEMKETKLPGDKGLVLMSRAKHHAISAK 135

  Fly   136 LHQPFDFKSEKPLVVQYEITIQKGQECGGSYLKLLSAGKETEQLQTFNDKTPYTIMFGPDKCGKD 200
            |::||.|.: |||:||||:..|.|.||||:|:||||...|. .|..|:|||||||||||||||:|
Mouse   136 LNKPFLFDT-KPLIVQYEVNFQNGIECGGAYVKLLSKTAEL-SLDQFHDKTPYTIMFGPDKCGED 198

  Fly   201 VTIHFIFKHVNPINGTITEKHCNKPNNSFEEPFKDKLPHLYQLVVRPDNSFEIRIDHKIIKEGSL 265
            ..:||||:|.||..|...|||..:|:...:..|.||..|||.|::.|||||||.:|..::..|:|
Mouse   199 YKLHFIFRHKNPKTGVYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNL 263

  Fly   266 LTDFKPPVNPPAEIDDPNDHKPDSWDEREKIPDPTVHKPEDWDENETLKLPD------------- 317
            |.|..|||||..||:||.|.||:.||||.||.||...||:||||:...|:||             
Mouse   264 LNDMTPPVNPSREIEDPEDRKPEDWDERPKIADPDAVKPDDWDEDAPSKIPDEEATKPEGWLDDE 328

  Fly   318 ADMIFDPTATKPEDWDDEIDGEWQAPMVDNPVCKKDQTCGI-----IRNPNYKGKWIAPMIDNPN 377
            .:.|.||.|.||||||:::||||:||.:.||.|:....||:     |.||||||||..|||||||
Mouse   329 PEYIPDPDAEKPEDWDEDMDGEWEAPQIANPKCESAPGCGVWQRPMIDNPNYKGKWKPPMIDNPN 393

  Fly   378 YQGKWAPRKIANPDFFEDLKPFQMTPISAVGLELWSMSSDILFDNLIITDDVEVARDFAANSFDI 442
            |||.|.||||.||||||||:||:|||.||:|||||||:|||.|||.||:.|..|..|:|.:.:.:
Mouse   394 YQGIWKPRKIPNPDFFEDLEPFKMTPFSAIGLELWSMTSDIFFDNFIISGDRRVVDDWANDGWGL 458

  Fly   443 KRRYIDRERDSIVNKVVELVKDYPSIWAIGL--VAIVALVALTKCCRFGTTKIQESAAAESKKTD 505
            |:.........:|.:::|..::.|.:|.:.:  ||:...:.:..||    :..::|.|.|.||||
Mouse   459 KKAADGAAEPGVVLQMLEAAEERPWLWVVYILTVALPVFLVILFCC----SGKKQSNAMEYKKTD 519

  Fly   506 DPQPHEPRPWGSRMSRAKKWKLTIPPRRAYSCPLPPKKKLDDNEWKFKAAKKQKHTQTKESNTEE 570
            .|||......|..                     ..|.|.|:.|.:.|..:|||      |:.||
Mouse   520 APQPDVKDEEGKE---------------------EEKNKRDEEEEEEKLEEKQK------SDAEE 557

  Fly   571  570
            Mouse   558  557

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1924NP_572788.2 Calreticulin 70..425 CDD:278680 208/372 (56%)
CanxNP_001103969.1 Calreticulin 72..441 CDD:278680 208/372 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..347 43/85 (51%)
P domain (Extended arm). /evidence=ECO:0000250 277..410 72/132 (55%)
4 X approximate repeats 279..346 32/66 (48%)
Interaction with PPIB. /evidence=ECO:0000250 327..360 17/32 (53%)
4 X approximate repeats 349..406 34/56 (61%)
Sufficient to mediate interaction with SGIP1. /evidence=ECO:0000269|PubMed:21747946 504..591 23/85 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 514..591 20/71 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167835704
Domainoid 1 1.000 502 1.000 Domainoid score I343
eggNOG 1 0.900 - - E1_KOG0675
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1324
Inparanoid 1 1.050 561 1.000 Inparanoid score I1087
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48587
OrthoDB 1 1.010 - - D230478at33208
OrthoFinder 1 1.000 - - FOG0001260
OrthoInspector 1 1.000 - - mtm8849
orthoMCL 1 0.900 - - OOG6_102144
Panther 1 1.100 - - O PTHR11073
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X875
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.770

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