DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1924 and clgn

DIOPT Version :9

Sequence 1:	NP_572788.2	Gene:	CG1924 / 32180	FlyBaseID:	FBgn0030377	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_002932081.3	Gene:	clgn / 100494636	XenbaseID:	XB-GENE-981033	Length:	593	Species:	Xenopus tropicalis

Alignment Length:	599	Identity:	231/599 - (38%)
Similarity:	324/599 - (54%)	Gaps:	112/599 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LLSAVKAIDSDLEWDDFEDVDVEDVQQEDVDEKPT------YKSPVIDAKKFHFADHFDDMEAST 81
            ||.|:.|.::..|.|:..:..::|.  ||..|:|:      ||:||.....| |.:.|||  .:.
Frog    12 LLVALTAAEAHSEQDEDSEDGLDDT--EDYREEPSTFLQVEYKTPVPMGDVF-FTETFDD--GTL 71

  Fly    82 RRWVLSQAKKDDIADEISKYDGIWNWEPPQRMVWANDLGLVLKSKAKHAAIAAHLHQPFDFKSEK 146
            ..||||:..|::..:||:||||.|..|..:......|:||||||.|:|.||:|.|.:.|.|  :|
Frog    72 DSWVLSKTVKEEADEEIAKYDGKWAVEELKENKVPGDMGLVLKSTARHHAISAKLKKTFTF--DK 134

  Fly   147 PLVVQYEITIQKGQECGGSYLKLLSAGKETEQLQTFNDKTPYTIMFGPDKCGKDVTIHFIFKHVN 211
            ||:||||:..|.|.:|||:|:||||..... .|:.|:|:|.|||||||||||:|..:||||:|.|
Frog   135 PLIVQYEVNFQDGIDCGGAYIKLLSESDHL-NLEEFHDRTSYTIMFGPDKCGEDYKVHFIFRHKN 198

  Fly   212 PINGTITEKHCNKPNNSFEEPFKDKLPHLYQLVVRPDNSFEIRIDHKIIKEGSLLTDFKPPVNPP 276
            |:.|...|||..:|....::.|.||..|||.|:|:|||::||.||..::.:|||..|..||:||.
Frog   199 PVIGDYDEKHAKRPEVDLKKYFTDKKTHLYTLIVKPDNTYEILIDQSVVGQGSLRDDVIPPLNPL 263

  Fly   277 AEIDDPNDHKPDSWDEREKIPDPTVHKPEDWDENETLKLPDAD-------------MIFDPTATK 328
            .|||||.|.||..||||.|||||...||:||||....::.|.:             .|.|..|.|
Frog   264 KEIDDPKDKKPKEWDERAKIPDPNAVKPDDWDEGGPEEIEDLNAVKPEGWLDNEPHFILDMNAEK 328

  Fly   329 PEDWDDEIDGEWQAPMVDNPVCKKDQTCGI-----IRNPNYKGKWIAPMIDNPNYQGKWAPRKIA 388
            |.||:..:||||:||.:.|..|:....||:     |:||:|||||..|:|:||||||.|.||||.
Frog   329 PSDWNANMDGEWEAPYIPNANCESAPGCGVWKRPMIKNPDYKGKWKPPLIENPNYQGIWKPRKIK 393

  Fly   389 NPDFFEDLKPFQMTPISAVGLELWSMSSDILFDNLIITDDVEVARDFAANSFDIKRRYIDRERDS 453
            |..:||||.||:|||.||||||||||:|||.|||.||..|.|||..:|::|:.:|:........|
Frog   394 NSHYFEDLNPFKMTPFSAVGLELWSMTSDIYFDNFIICSDKEVADRWASDSWGLKKLVASANEPS 458

  Fly   454 IVNKVVELVKDYPSIWAIG-LVAIVALVALTKCCRFGTTKIQESAAAESKKTDDPQPHEPRPWGS 517
            ::::::...::.|.:|.:. |.|.:.:..|...|
Frog   459 MLSQLLSAAEERPWLWVLYILTAALPVGLLVLFC------------------------------- 492

  Fly   518 RMSRAKKWKLTIPPRRAYSCPLPPKKKLDDNEWKF--------------------------KAAK 556
                   |               |:||:::.|..|                          ||::
Frog   493 -------W---------------PRKKMEEEEEDFDFKLSDLCDESYLELQSNAKEEADGGKASE 535

  Fly   557 KQKHTQTKESNTEE 570
            .:::.:::|...||
Frog   536 NEEYERSEEEGDEE 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1924	NP_572788.2	Calreticulin	70..425	CDD:278680	188/372 (51%)
clgn	XP_002932081.3	Calreticulin	62..430	CDD:395201	188/372 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	497	1.000	Domainoid score	I359
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	567	1.000	Inparanoid score	I1059
OMA	1	1.010	-	-		QHG48587
OrthoDB	1	1.010	-	-		D230478at33208
OrthoFinder	1	1.000	-	-		FOG0001260
OrthoInspector	1	1.000	-	-		mtm9512
Panther	1	1.100	-	-	O	PTHR11073
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X875
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080